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Transcraneal Magnetic Stimulation Improves Sleep Parameters in Patients Affected with Imsomnia Associated to Electroencephalographic Abnormalities
American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
Psychiatry Department, Hospital General Naval de Alta Especialidad, Ciudad de México, México
Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
Mathematics Department, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
- 1 American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
- 2 Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
- 3 Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
- 4 Psychiatry Department, Hospital General Naval de Alta Especialidad, Ciudad de México, México
- 5 Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
- 6 Mathematics Department, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
- 7 American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
- 8 American British Cowdray Medical Center, Neurological Center, Santa Fe Campus, Ciudad de México, México
- 9 Sleep Disorders Clinic, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México
Neuroscience and Medicine·Volume 05 (2014)·Pages 72–77·Published 6 March 2014·DOI10.4236/nm.2014.51010
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Abstract
Insomnia is one of the most frequently observed sleep disorders, affecting nearly 10% of the general population. It has multiple etiological factors. Recently, it has been reported that EEG abnormalities are associated with insomnia in patients previously diagnosed as idiopathic insomniacs. In addition, transcranial magnetic stimulation (TMS) has shown to be effective in the treatment of disorders characterized by neural hyper-excitability. Method: In the present study, patients with insomnia and EEG abnormalities were submitted to slow repetitive trans-cranial magnetic stimulation, for 15 minutes daily during 10 days. Polysomnographic recordings were performed before and after TMS. Results: The results indicate that the presence of EEG abnormalities significantly decreased after TMS. In addition, most of the sleep parameters showed significant improvement. Conclusions: These data support the notion that TMS is a reliable therapeutic tool for patients affected with abnormalities linked to neuronal hyper-excitability.
KeywordsInsomniaTranscraneal Magnetic StimulationEEG AbnormalitiesHyperexcitabilitySleep ArchitecturePolysomnographic
- Arana, L., Sánchez, E., Collado, C., Castillo, M., González, R., Jiménez, A., Prospero, G. and Velázquez, M. (2011) Electroencephalographic Abnormalities in Patients with Idiopathic Insomnia. Neuroscience & Medicine, 2, 178-184. http://dx.doi.org/10.4236/nm.2011.23024
- Cantello, R., Civardi, C., Cavalli, A., Varrasi, C., Tarletti, R., Monaco, F. and Migliaretti, G. (2000) Cortical Excitability in Cryptogenic Localization-Related Epilepsy: Interictaltranscranial Magnetic Stimulation Studies. Epilepsia, 41, 694-704. http://dx.doi.org/10.1111/j.1528-1157.2000.tb00230.x
- Perlis, M.L., Merica, H., Smith, M.T. and Giles, D.E. (2001) Beta EEG Activity and Insomnia. Sleep Medicine Reviews, 5, 365-376. http://dx.doi.org/10.1053/smrv.2001.0151
- Nofzinger, E.A., Buysse, D.J., Germain, A., et al. (2004) Functional Neuroimaging Evidence for Hyperarousal in Insomnia. American Journal of Psychiatry, 161, 2126-2128. http://dx.doi.org/10.1176/appi.ajp.161.11.2126
- Berman, R.M., Narasimhan, M., Sanacora, G., Miano, A.P., Hoffman, R.E., Hu, S., Charney, D.S. and Boutros, N.N. (2000) A Randomized Clinical Trial of Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depression. Biological Psychiatry, 47, 332-337. http://dx.doi.org/10.1016/S0006-3223(99)00243-7
- Hoffman, R. and Cavus, I. (2002) Slow Transcranial Magnetic Stimulation, Long-Term Depotentiation, and Brain Hyperexcitability Disorders. American Journal of Psychiatry, 159, 1093-1102. http://dx.doi.org/10.1176/appi.ajp.159.7.1093
- Grisaru, N., Amir, M., Cohen, H. and Kaplan, Z. (1998) Effect of Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder: A Preliminary Study. Biological Psychiatry, 44, 53-55. http://dx.doi.org/10.1016/S0006-3223(98)00016-X
- Haraldsson, H.M., Ferrarelli, F., et al. (2004) Transcranial Magnetic Stimulation in the Investigation and Treatment of Schizophrenia: A Review. Schizophrenia Research, 71, 1-16. http://dx.doi.org/10.1016/j.schres.2003.10.006
- Rechtschaffen, A. and Kales, A. (1968) A Manual of Standardized Terminology: Techniques and Scoring System of Sleep Stages of Human Subjects. UCLA Brain Information Service/Brain Research Institute, Los Angeles.
- The American Academy of Sleep Medicine (2007) Rules, Terminology and Technical Specifications. The American Academy of Sleep Medicine, Westchester.
- Rosenberg, P.B., Mehndiratta, R.B., Mehndiratta, Y.P., Wamer, A., Rosse, R.B. and Balish, M. (2002) Repetitive Transcranial Magnetic Stimulation Treatment of Comorbid Posttraumatic Stress Disorder and Major Depression. Journal of Neuropsychiatry and Clinical Neurosciences, 14, 270-276. http://dx.doi.org/10.1176/appi.neuropsych.14.3.270