Diabetes is a common chronic disease with a prevalence of 8.3%. Diabetic neuropathy is a common neurological complication of the disease which interferes with the quality of life (QoL) of patients due to painful symptoms leading to disability. This study aims to evaluate the effects of diabetic neuropathy on disability and QoL. Sixty-two patients with clinical diabetic neuropathy were enrolled in the study. All underwent electrophysiological evaluations. Brief disability scale (BDS) and Short form-36 (SF-36) were used to evaluate disability and QoL of patients. Results revealed a negative correlation among increased pain quality assessment scale (PQAS), BDQ scores and QoL, emphasizing the interfering effect of pain on QoL of patients with diabetic neuropathy.
KeywordsDiabetic NeuropathyPainDisabilityQuality of Life
International Diabetes Federation (2013) IDF Diabetes Atlas. 6th Edition, International Diabetes Federation, Brussels. http://www.idf.org/diabetesatlas.
Callaghan, B.C., Cheng, H.T., Stables, C.L., Smith, A.L. and Feldman, E.L. (2012) Diabetic Neuropathy: Clinical Manifestations and Current Treatments. The Lancet Neurology, 11, 521-534. http://dx.doi.org/10.1016/S1474-4422(12)70065-0
Sinnreich, M., Taylor, B.V. and Dyck, P.J. (2005) Diabetic Neuropathies. Classification, Clinical Features, and Pathophysiological Basis. Neurologist, 11, 63-79. http://dx.doi.org/10.1097/01.nrl.0000156314.24508.ed
Smith, A.G. and Singleton, J.R. (2012) Diabetic Neuropathy. CONTINUUM: Lifelong Learning in Neurology, 18, 60-84. http://dx.doi.org/10.1212/01.CON.0000411568.34085.3e
Deli, G., Bosnyak, E., Pusch, G., Komoly, S. and Feher, G. (2013) Diabetic Neuropathies: Diagnosis and Management. Neuroendocrinology, 98, 267-80. http://dx.doi.org/10.1159/000358728
Boulton, A. (2005) Management of Diabetic Peripheral Neuropathy. Clinical Diabetes, 23, 9-15. http://dx.doi.org/10.2337/diaclin.23.1.9
Galer, B., Gianas, A., and Jensen, M. (2000) Painful Diabetic Polyneuropathy: Epidemiology, Pain Description, and Quality of Life. Diabetes Research and Clinical Practice, 47, 123-128. http://dx.doi.org/10.1016/S0168-8227(99)00112-6
Kimura, J. (2001) Assessment of Individual Nerves. Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice. 3rd Edition, Oxford University Press, New York, 130-177.
Preston, D.C. and Shapiro, B.E. (2005) Electromyography and Neuromuscular Disorders. In: Preston, D.C. and Shapiro, B.E., Eds., Polyneuropathy, 2nd Edition, Chapter 23, Butterworth-Heinemann, Newton, 353-390.
Sahin, N., Bodur, S., Salli, A. and Ugurlu, H. (2010) Reliability and Validity of the Turkish Version the Pain Quality Assessment Scale in Patients with Carpal Tunnel Syndrome. Noble Medical, 6, 26-33.
Stewart, A.L., Hays, R.D. and Ware Jr., J.E. (1988) The MOS Short-Form General Health Survey: Reliability and Validity in a Patient Population. Medical Care, 26, 724-735. http://dx.doi.org/10.1097/00005650-198807000-00007
Kaplan, I. (1995) Yarikirsalbirsaglikocaginabasvuranhastalardaruhsalbozukluklarinyetiyitimiileiliskisi. Türk Psikiyatri Dergisi, 6, 169-179.
Ware Jr., J.E. and Sherbourne, C.D. (1992) The MOS 36-Item Short-Form Health Survey (SF-36), I. Conceptual Framework and Item Selection. Medical Care, 30, 473-483. http://dx.doi.org/10.1097/00005650-199206000-00002
Koçyigit, H., Aydemir, Ö., Fisek, G., Ölmez, N. and Memis, A. (1999) Kisa Form-36’ nin (KF-36). Türkçeiçingüvenilirligivegeçerliligi. Romatizmalhastaligiolanbirgrup hasta ileçalisma. Ilaçve Tedavi Dergisi, 12, 102-106.
England, J.D., Gronseth, G.S., Franklin, G., Miller, R.G., Asbury, A.K., Carter, G.T., et al. (2005) Distal Symmetric Polyneuropathy: A Definition for Clinical Research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology, 64, 199-207. http://dx.doi.org/10.1212/01.WNL.0000149522.32823.EA
Abbott, C.A., Malik, R.A., van Ross, E.R., Kulkarni, J. and Boulton, A.J. (2011) Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the UK. Diabetes Care, 34, 2220-2224. http://dx.doi.org/10.2337/dc11-1108
Erbas, T., Ertas, M., Yucel, A., Keskinaslan, A. and Senocak, M., TURNEP Study Group (2011) Prevalence of Peripheral Neuropathy and Painful Peripheral Neuropathy in Turkish Diabetic Patients. Journal of Clinical Neurophysiology, 28, 51-55. http://dx.doi.org/10.1097/WNP.0b013e3182051334
Ziegler, D., Papanas, N., Vinik, A.I. and Shaw, J.E. (2014) Epidemiology of Polyneuropathy in Diabetes and Prediabetes. Handbook of Clinical Neurology, 126, 3-22. http://dx.doi.org/10.1016/B978-0-444-53480-4.00001-1
Gore, M., Brandenburg, N.A., Dukes, E., Hoffman, D.L., Tai, K.S. and Stacey, B. (2005) Pain Severity in Diabetic Peripheral Neuropathy Is Associated with Patient Functioning, Symptom Levels of Anxiety and Depression, and Sleep. Journal of Pain and Symptom Management, 30, 374-385. http://dx.doi.org/10.1016/j.jpainsymman.2005.04.009
Spasic, A., Radovanovic, V.R., Ðordevic, C.A., Stefanovic, N. and Cvetkovic, T. (2014) Quality of Life in Type 2 Diabetic Patients. Acta Facultatis Medicae Naissensis, 31, 193-200. http://dx.doi.org/10.2478/afmnai-2014-0024
Venkataraman, K., Wee, H.L., Leow, M.K., Tai, E.S., Lee, J., Lim, S.C., et al. (2013) Associations between Complications and Health-Related Quality of Life in Individuals with Diabetes. Clinical Endocrinology, 78, 865-873. http://dx.doi.org/10.1111/j.1365-2265.2012.04480.x
Happich, M., John, J., Stamenitis, S., Clouth, J. and Polnau, D. (2008) The Quality of Life and Economic Burden of Neuropathy in Diabetic Patients in Germany in 2002—Results from the Diabetic Microvascular Complications (DIMICO) Study. Diabetes Research and Clinical Practice, 81, 223-230. http://dx.doi.org/10.1016/j.diabres.2008.03.019
Benbow, S.J., Wallymahmed, M.E. and MacFarlane, I.A. (1998) Diabetic Peripheral Neuropathy and Quality of Life. QJM, 91, 733-737. http://dx.doi.org/10.1093/qjmed/91.11.733
Van Acker, K., Bouhassira, D., De Bacquer, D., Matthys, K., Raemen, H., et al. (2009) Prevalence and Impact on Quality of Life of Peripheral Neuropathy with or without Neuropathic Pain in Type 1 and Type 2 Diabetic Patients Attending Hospital Outpatients Clinics. Diabetes & Metabolism, 35, 206-213. http://dx.doi.org/10.1016/j.diabet.2008.11.004
Dobrota, V.D., Hrabac, P., Skegro, D., Smiljanic, R., Dobrota, S., Prkacin, I., et al. (2014) The Impact of Neuropathic Pain and Other Comorbidities on the Quality of Life in Patients with Diabetes. Health and Quality of Life Outcomes, 12, 171. http://dx.doi.org/10.1186/s12955-014-0171-7
Currie, C.J., Poole, C.D., Woehl, A., Morgan, C.L., Cawley, S., Rousculp, M.D., et al. (2006) The Health-Related Utility and Health-Related Quality of Life of Hospital-Treated Subjects with Type 1 or Type 2 Diabetes with Particular Reference to Differing Severity of Peripheral Neuropathy. Diabetologia, 49, 2272-2280. http://dx.doi.org/10.1007/s00125-006-0380-7
Vukojevic, Z., Pekmezovic, T., Nikolic, A., Peric, S., Basta, I., Marjanovic, I. and Lavrnic, D. (2014) Correlation of Clinical and Neurophysiological Findings with Health-Related Quality of Life in Patients with Diabetic Polyneuropathy. Vojnosanitetski Pregled, 71, 833-838. http://dx.doi.org/10.2298/VSP120919015V