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Neuroscience & Medicine is a peer reviewed international journal dedicated to the latest advancements of neuroscience. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to NM must be pre…
Lucas Toibaro, Magdalena Pereyra, Julieta Pastorino, Ariela Smigliani, Florencia Ocariz, Germán Ortmann, María Milagros Galardi, María Belén Gori, Silvia Kochen
Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not become seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. However, the optimal stimulatio…
El Mrabet Fatima Zahra, Lagbouri Ibtissam, Mesfioui Abdelhalim, El Hessni Aboubakr, Ouichou Ali
The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melat…
Christine E. Oborski, Rathna Iyer, Bruce A. Maguire, Gary Bora, Kevin Atchison, Nikolay Pozdnyakov, Kathleen Wood, Christine Parker, Timothy A. Subashi, Martin Pettersson, Douglas S. Johnson, Kelly R. Bales
γ -Secretase is involved in the final processing of the amyloid precursor protein into a heterogeneous pool of β -amyloid (A β ) peptides. Current Alzheimer’s disease drug discovery efforts include targeting γ -secretase activity in brain to attenuate product…
Luis Gutierrez Cabello, Isabel Gómez-Ruiz, Angel Aguilar Alonso, Salvador Pedraza Gutiérrez
Objective: To investigate the association of ischaemic and haemorrhagic strokes with the site of subcortical focal cerebrovascular injuries with affective, behavioural and cognitive dysfunctions in the acute phase and after three months. Sample: 58 patients w…
Wilfried Dimpfel, Klaus Koch, Gabriele Weiss
Pascoflair ? 425 mg is a herbal drug based on Passiflora incarnata dry extract and is registered in different countries for the treatment of nervous restlessness and anxiety and also as an aid to sleep. The study was initiated for the quantitative assessment…
Grete Kjelvik, Ole Bosnes, Ragnhild Omli, Liv Heidi Skotnes, Asta K. Håberg, Linda R. White
Objective: To introduce the concept that there might be “nothing to smell” to the Brief Smell Identification Test (B-SIT), with a view to masking olfactory deficits, particularly from healthy control participants in research studies. Methods: Seventy-one elde…
Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Ko Hosokawa, Takashi Mashimo
Abnormal serotonin 2C receptor (5HTR2C) alternative splicing and RNA editing are involved in the etiology of pain disorders. Functional 5HTR2C can only be generated when alternative exon Vb is included within the mRNA; the small nucleolar RNA RBII-52 is compl…
Matthew Sorenson, Leonard Jason, Athena Lerch, Nicole Porter, Jonna Peterson, Herbert Mathews
Background and Objective: Previous research has speculated on the role of pro- and inflammatory immune mediators in the etiologic process of fatigue, with contrasting findings. The preponderance of the evidence supports the role of inflammatory mediators in t…
Ian I. Kneebone, Nadina B. Lincoln
Background: Stroke has the greatest disabling impact of any chronic disease. Psychological changes including emotional, behavioural and cognitive changes can be common after stroke. Recently more attention has been given to these concerns. Content: This paper…
Steven Lowrance, Jessica Matchynski, Julien Rossignol, Nicholas Dekorver, Michael Sandstrom, Gary Dunbar
The purpose of this study was to determine if the substituted pyrimidine, CXB-909 (formerly known as KP544) which has been shown to amplify the effects of nerve growth factor in elevating choline-acetyltransferase activity in vitro, could attenuate memory def…
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Neuroscience & Medicine is a peer reviewed international journal dedicated to the latest advancements of neuroscience. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts submitted to NM must be pre… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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