In this short review paper, the significant and profound impacts of the 5-steps rule have been briefly recalled with crystal clear convincingness.
Keywords5-Step RulesSignificant ImpactsProfound ImpactsCurie Temperature
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Butt, A.H. and Khan, Y.D. (2018) Prediction of S-Sulfenylation Sites Using Statistical Moments Based Features via Chou’s 5-Step Rule. International Journal of Peptide Research and Therapeutics (IJPRT), 17, 711-738.
Awais, M., Hussain, W., Khan, Y.D., Rasool, N., Khan, S.A. and Chou, K.C. (2019) iPhosH-PseAAC: Identify Phosphohistidine Sites in Proteins by Blending Statistical Moments and Position Relative Features According to the Chou’s 5-Step Rule and General Pseudo Amino Acid Composition. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 19, 1-21. https://doi.org/10.1109/TCBB.2019.2919025
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Chen, Y. and Fan, X. (2019) Use Chou’s 5-Steps Rule to Reveal Active Compound and Mechanism of Shuangsheng Pingfei San on Idiopathic Pulmonary Fibrosis. Current Molecular Medicine, 19, 511-563.
Du, X., Diao, Y., Liu, H. and Li, S. (2019) MsDBP: Exploring DNA-Binding Proteins by Integrating Multi-Scale Sequence Information via Chou’s 5-Steps Rule. Journal of Proteome Research, 18, 3119-3132. https://doi.org/10.1021/acs.jproteome.9b00226
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Ehsan, A., Mahmood, M.K., Khan, Y.D., Barukab, O.M., Khan, S.A. and Chou, K.C. (2019) iHyd-PseAAC (EPSV): Identify Hydroxylation Sites in Proteins by Extracting Enhanced Position and Sequence Variant Feature via Chou’s 5-Step Rule and General Pseudo Amino Acid Composition. Current Genomics, 20, 124-133. https://doi.org/10.2174/1389202920666190325162307
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Hussain, W., Khan, Y.D., Rasool, N., Khan, S.A. and Chou, K.C. (2019) SPrenylC-PseAAC: A Sequence-Based Model Developed via Chou’s 5-Steps Rule and General PseAAC for Identifying S-Prenylation Sites in Proteins. Journal of Theoretical Biology, 468, 1-11. https://doi.org/10.1016/j.jtbi.2019.02.007
Jun, Z. and Wang, S.Y. (2019) Identify Lysine Neddylation Sites Using Bi-Profile Bayes Feature Extraction via the Chou’s 5-Steps Rule and General Pseudo Components. Current Genomics, 20, 592-601. https://doi.org/10.2174/1389202921666191223154629
Khan, S., Khan, M., Iqbal, N., Hussain, T., Khan, S.A. and Chou, K.C. (2019) A Two-Level Computation Model Based on Deep Learning Algorithm for Identification of piRNA and Their Functions via Chou’s 5-Steps Rule. Human Genetics, 19, 756-799. https://doi.org/10.1007/s10989-019-09887-3
Khan, Z.U., Ali, F., Khan, I.A., Hussain, Y. and Pi, D. (2019) iRSpot-SPI: Deep Learning-Based Recombination Spots Prediction by Incorporating Secondary Sequence Information Coupled with Physio-Chemical Properties via Chou’s 5-Step Rule and Pseudo Components. Chemometrics and Intelligent Laboratory Systems (CHEMOLAB), 189, 169-180. https://doi.org/10.1016/j.chemolab.2019.05.003
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Le, N.Q.K. (2019) iN6-methylat (5-Step): Identifying DNA N(6)-methyladenine Sites in Rice Genome Using Continuous Bag of Nucleobases via Chou’s 5-Step Rule. Molecular Genetics and Genomics: MGG, 294, 1173- 1182. https://doi.org/10.1007/s00438-019-01570-y
Le, N.Q.K., Yapp, E.K.Y., Ho, Q.T., Nagasundaram, N., Ou, Y.Y. and Yeh, H.Y. (2019) iEnhancer-5Step: Identifying Enhancers Using Hidden Information of DNA Sequences via Chou’s 5-Step Rule and Word Embedding. Analytical Biochemistry, 571, 53-61. https://doi.org/10.1016/j.ab.2019.02.017
Le, N.Q.K., Yapp, E.K.Y., Ou, Y.Y. and Yeh, H.Y. (2019) iMotor-CNN: Identifying Molecular Functions of Cytoskeleton Motor Proteins Using 2D Convolutional Neural Network via Chou’s 5-Step Rule. Analytical Biochemistry, 575, 17-26. https://doi.org/10.1016/j.ab.2019.03.017
Liang, R., Xie, J., Zhang, C., Zhang, M., Huang, H., Huo, H., Cao, X. and Niu, B. (2019) Identifying Cancer Targets Based on Machine Learning Methods via Chou’s 5-Steps Rule and General Pseudo Components. Current Topics in Medicinal Chemistry, 19, 2301-2317. https://doi.org/10.2174/1568026619666191016155543
Liang, Y. and Zhang, S. (2019) Identifying DNase I Hypersensitive Sites Using Multi-Features Fusion and F-Score Features Selection via Chou’s 5-Steps Rule. Biophysical Chemistry, 253, Article ID: 106227. https://doi.org/10.1016/j.bpc.2019.106227
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Malebary, S.J., Rehman, M.S.U. and Khan, Y.D. (2019) iCrotoK-PseAAC: Identify Lysine Crotonylation Sites by Blending Position Relative Statistical Features According to the Chou’s 5-Step Rule. PLoS ONE, 14, e0223993. https://doi.org/10.1371/journal.pone.0223993
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Yang, L., Lv, Y., Wang, S., Zhang, Q., Pan, Y., Su, D., Lu, Q. and Zuo, Y. (2019) Identifying FL11 Subtype by Characterizing Tumor Immune Microenvironment in Prostate Adenocarcinoma via Chou’s 5-Steps Rule. Genomics, 112, 1500-1515. https://doi.org/10.1016/j.ygeno.2019.08.021
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Akmal, M.A., Hussain, W., Rasool, N., Khan, Y.D., Khan, S.A. and Chou, K.C. (2020) Using Chou’s 5-Steps Rule to Predict O-Linked Serine Glycosylation Sites by Blending Position Relative Features and Statistical Moment. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 1-12. https://doi.org/10.1109/TCBB.2020.2968441
Bouziane, H. and Chouarfia, A. (2020) Use of Chou’s 5-Steps Rule to Predict the Subcellular Localization of Gram-Negative and Gram-Positive Bacterial Proteins by Multi-Label Learning Based on Gene Ontology Annotation and Profile Alignment. Journal of Integrative Bioinformatics. https://doi.org/10.1515/jib-2019-0091
Charoenkwan, P., Schaduangrat, N., Nantasenamat, C., Piacham, T. and Shoombuatong, W. (2020) iQSP: A Sequence-Based Tool for the Prediction and Analysis of Quorum Sensing Peptides via Chou’s 5-Steps Rule and Informative Physicochemical Properties. International Journal of Molecular Sciences, 21, 75. https://doi.org/10.3390/ijms21010075
Charoenkwan, P., Schaduangrat, N., Nantasenamat, C., Piacham, T. and Shoombuatong, W. (2020) Correction: Shoombuatong, W., et al. iQSP: A Sequence-Based Tool for the Prediction and Analysis of Quorum Sensing Peptides via Chou’s 5-Steps Rule and Informative Physicochemical Properties. International Journal of Molecular Sciences, 21, 75. https://doi.org/10.3390/ijms21072629
Chen, Y. and Fan, X. (2020) Use of Chou’s 5-Steps Rule to Reveal Active Compound and Mechanism of Shuangshen Pingfei San on Idiopathic Pulmonary Fibrosis. Current Molecular Medicine, 20, 220-230. https://doi.org/10.2174/1566524019666191011160543
Dobosz, R., Mucko, J. and Gawinecki, R. (2020) Using Chou’s 5-Step Rule to Evaluate the Stability of Tautomers: Susceptibility of 2-[(Phenylimino)-methyl]-cyclohexane-1,3-diones to Tautomerization Based on the Calculated Gibbs Free Energies. Energies, 13, 183. https://doi.org/10.3390/en13010183
Du, L., Meng, Q., Jiang, H. and Li, Y. (2020) Using Evolutionary Information and Multi-Label Linear Discriminant Analysis to Predict the Subcellular Location of Multi-Site Bacterial Proteins via Chou’s 5-Steps Rule. IEEE Access, 8, 56452-56461. https://doi.org/10.1109/ACCESS.2020.2982160
Dutta, A., Dalmia, A., R, A., Singh, K.K. and Anand, A. (2020) Using the Chou’s 5-Steps Rule to Predict Splice Junctions with Interpretable Bidirectional Long Short-Term Memory Networks. Computers in Biology and Medicine, 116, Article ID: 103558. https://doi.org/10.1016/j.compbiomed.2019.103558
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Kabir, M., Ahmad, S., Iqbal, M. and Hayat, M. (2020) iNR-2L: A Two-Level Sequence-Based Predictor Developed via Chou’s 5-Steps Rule and General PseAAC for Identifying Nuclear Receptors and Their Families. Genomics, 112, 276-285. https://doi.org/10.1016/j.ygeno.2019.02.006
Khan, Y.D., Amin, N., Hussain, W., Rasool, N., Khan, S.A. and Chou, K.C. (2020) iProtease-PseAAC(2L): A Two-Layer Predictor for Identifying Proteases and Their Types Using Chou’s 5-Step-Rule and General PseAAC. Analytical Biochemistry, 588, Article ID: 113477. https://doi.org/10.1016/j.ab.2019.113477
Lin, W., Xiao, X., Qiu, W. and Chou, K.C. (2020) Use Chou’s 5-Steps Rule to Predict Remote Homology Proteins by Merging Grey Incidence Analysis and Domain Similarity Analysis. Natural Science, 12, 181-198. https://doi.org/10.4236/ns.2020.123016
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Nguyen, D., Ho-Quang, T., Nguyen Quoc Khanh, L., Dinh-Phan, V. and Ou, Y.Y. (2020) Use Chou’s 5-Steps Rule with Different Word Embedding Types to Boost Performance of Electron Transport Protein Prediction Model. IEEE/ACM Transactions on Computational Biology and Bioinformatics. https://doi.org/10.1109/TCBB.2020.3010975
Pandey, R.P., Kumar, S., Ahmad, S., Vibhuti, A., Raj, V.S., Verma, A.K., Sharma, P. and Leal, E. (2020) Use Chou’s 5-Steps Rule to Evaluate Protective Efficacy Induced by Antigenic Proteins of Mycobacterium tuberculosis Encapsulated in Chitosan Nanoparticles. Life Sciences, 256, Article ID: 117961. https://doi.org/10.1016/j.lfs.2020.117961
Roy, T. and Bhattacharjee, P. (2020) A LabVIEW-Based Real-Time Modeling Approach via Chou’s 5-Steps Rule for Detection of Abnormalities in Cancer Cells. Gene Reports, Article ID: 100788. https://doi.org/10.1016/j.genrep.2020.100788
Song, C. and Yang, B. (2020) Use Chou’s 5-Step Rule to Classify Protein Modification Sites with Neural Network. Scientific Programming, 2020, Article ID: 8894633. https://doi.org/10.1155/2020/8894633
Song, C. and Yang, B. (2020) Use Chou’s 5-Step Rule to Classify Protein Modification Sites with Neural Network. Scientific Programming, 2020, Article ID: 8894633. https://doi.org/10.1155/2020/8894633
Vishnoi, S., Garg, P. and Arora, P. (2020) Physicochemical n-Grams Tool: A Tool for Protein Physicochemical Descriptor Generation via Chou’s 5-Step Rule. Chemical Biology & Drug Design, 95, 79-86. https://doi.org/10.1111/cbdd.13617
Vundavilli, H., Datta, A., Sima, C., Hua, J., Lopes, R. and Bittner, M. (2020) Using Chou’s 5-Steps Rule to Model Feedback in Lung Cancer. IEEE Journal of Biomedical and Health Informatics, 21, 2430-2438. https://doi.org/10.1109/JBHI.2019.2958042
Yang, L., Lv, Y., Wang, S., Zhang, Q., Pan, Y., Su, D., Lu, Q. and Zuo, Y. (2020) Identifying FL11 Subtype by Characterizing Tumor Immune Microenvironment in Prostate Adenocarcinoma via Chou’s 5-Steps Rule. Genomics, 112, 1500-1515. https://doi.org/10.1016/j.ygeno.2019.08.021
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