The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on <i>Pseudomonas aeruginosa in Vitro </i> — Oak Academic Publishing
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The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on <i>Pseudomonas aeruginosa in Vitro </i>
Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
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Laboratory Department of the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China
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Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
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Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
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Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
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Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
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Laboratory Department of Chongzuo Maternal and Child Health Hospital, Chongzuo, China
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Laboratory Department of the Second People’s Hospital of Mengshan County, Mengshan County, China
1 Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
2 Laboratory Department of the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China
3 Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
4 Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
5 Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
6 Laboratory Department of the Second Affiliated Hospital of Guilin Medical College, Guilin, China
7 Laboratory Department of Chongzuo Maternal and Child Health Hospital, Chongzuo, China
8 Laboratory Department of the Second People’s Hospital of Mengshan County, Mengshan County, China
Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of Pseudomonas aeruginosa . Method: Pseudomonas aeruginosa strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against Pseudomonas aeruginosa drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P < 0.05); The combined effect of the two was dependent on strain and concentration. Conclusion: The combined use of baicalin and cefoperazone-sulbactam sodium has a certain synergistic bacteriostatic or bactericidal effect on drug-resistant strains of Pseudomonas aeruginosa .
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