The Trend of the Multidrug Resistance of <i>Helicobacter pylori</i> Strains Isolated in Chengdu

Abstract

Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug resistance to antibiotics, and Hp drug resistance is the main cause of Hp eradication failure. It is severe for the multidrug resistance of Hp. Objective: To investigate the changing trend of Helicobacter pylori (Hp) resistance to metronidazole, clarithromycin and amoxicillin in children and adults in Chengdu. Methods: The Hp strain determined the minimum antibacterial concentration (MIC) from 585 patients with upper gastrointestinal symptoms, metronidazole, clarithromycin and amoxicillin was measured by the E-test. Clinically isolated Hp strains were obtained by microaerobic condition culture as the diagnostic standard. Results: The Hp resistance to metronidazole and clarithromycin in children in Chengdu were: 17.65% (27/153) and 18.06 (78/432) in adults. The Hp resistance to metronidazole and amoxicillin in children in Chengdu were: 11.76% (18/153) and 13.19 (57/432) in adults. The Hp resistance to metronidazole, clarithromycin and amoxicillin in children in Chengdu were: 3.92% (6/153) and 10.41 (45/432) in adults. There were 76.92% of the strains which were resistant to metronidazole, 24.11% to clarithromycin, and 18.46% to amoxicillin. The drug resistance rate of Hp has increased year by year from 2017 to 2021 year, especially the drug resistance rate of Hp to clarithromycin and metronidazole has generally increased. Conclusions: The drug resistance rate of Hp has increased year by year from 2017 to 2021 year.