Nano materials is a new type of drug carriers with very promising application. In recent years, great progress was achieved in making drugs own the characteristics of targeted and con-trolled release via nanotechnologies. This paper addressed the capability of nano drugs on tar-geting to cells, penetrating through epicyte, controlled release and the security issues re-sulting from its using. We gave the prospect of nano drugs in biology and medicine applying.
Balogh, L.P. (2009) The future of nanomedicine and the future of Nanomedicine: NBM. Nanomedicine, 5, 1.
Shephard, M.J., Todd, D., Adair, B.M., Po, A.L.W., Mackie, D.P. and Scott, E.M. (2003) Immunogenicity of bovineparainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administra-tion to mice. Res. Vet. Sci., 74, 187-190.
Cui, Z.R.and Mumper, R.J. (2002) Intranasal administra-tion of plasmid DNA-coated nanoparticles results in en-hanced immune responses. J. Pharm. Pharmacol., 54, 1195-1203.
Vijayanathan, V., Thomas, T. and Thomas, T.J. (2002) DNA nanoparticles and development of DNA delivery vehicles for gene therapy. Biochemistry, 41, 14085-14094.
Cleland, J.L. (1998) Solvent evaporation processes for the production of controlled release biodegradable mi-crosphere formulations for therapeutics and vaccines. Biotechnol. Prog., 14, 102-107.
Esfand, R.and Tomalia, D.A. (2001) Poly (amidoamine) (PAMAM) dendrimers:from biomimicry to drug delivery and biomedical applications. Drug Discovery Today, 6, 427-436.
Aukunuru, J.V., Ayalasomayajula, S.P. and Kompella, U.B. (2003) Nanoparticle formulation enhances the de-livery and activity of a vascular endothelial growth factor antisense oligonucleotide in human retinal pigment epithelial cells. J. Pharm. Pharmacol., 55, 1199-1206.
Maeda, H., Wu, J., Sawa, Y., Matsumura, Y. and Hori, K. (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics:a review. J. Control. Re-lease, 65, 271-284.
Lukyanov, A.N. and Torchilin, V.P. (2004) Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv. Drug Delivery Rev. 56, 1273-1289.
Torchilin, V.P. (2002) PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv. Drug Delivery Rev., 54, 235-252.
Mitra, S., Gaur, U., Ghosh, P.C. and Maitra, A.N. (2001) Tumour targeted delivery of encapsulated dextran doxorubicin conjugate using chitosan nanoparticles as carrier. J. Control. Release, 74, 317-323.
Du, S.L., Pan, H., Lu, W.Y., Wang, J., Wu, J. and Wang J. Y. (2007) Cyclic Arg-Gly-Asp peptide-labeled liposomes for targeting drug therapy of hepatic fibros is in rats. J. Pharmacol. Exp. Ther., 322, 560-568.
Briz, O., Macias, R.I.R., Vallejo, M., Silva, A., Serrano, M.A. and Marin, J.J.G. (2003) Usefulness of liposomes loaded with cytos tatic bile acid derivatives to circum-vent chemotherapy res is tance of enterohepatic tumors. Mol. Pharmacol., 63, 742–750.
Saul, J.M., Annapragada, A.V. and Bellamkonda, R.V. (2006) A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. J. Control. Re-lease, 114, 277-287.
Hashida, M., Akamatsu, K., Nishikawa, M., Yamashita, F., Yoshikawa, H. and Takakura, Y. (2000) Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting. Pharmazie, 55, 202-205.
Chung, J.E., Yokoyama, M., Aoyagi, T., Sakurai, Y. and Okano, T. (1998) Effect of molecular architecture of hy-drophobically modified poly (N-isopropylacrylamide) on the formation of thermoresponsive core-shell micellar drug carriers. J. Control. Release, 53, 119-130.
Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y. and Okano, T. (1998) Preparation a characterization of thermally responsive block copolymer micelles compris-ing poly (N-isopropylacrylamide-β-DL-lactide). J. Con-trol. Release, 55, 87-98.
Meyer, O., Papahadjopoulos, D. and Leroux, J.C. (1998) Co- polymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes. FEBS Lett. 421, 61-64.
Stover, T.C., Kim, Y.S., Lowe, T.L. and Keste, M. (2008) Thermoresponsive and bio-degradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug. Biomaterials, 29, 359-369.
Na, K., Lee, E.S. and Bae, Y.H. (2003) Adriamycin loaded pullulan acetate/sulfonamide conjugate nanopar-ticles responding to tumor pH: pH-dependent cell inter-action, internalization and cytotoxicity in vitro. J. Con-trol. Release, 87, 3-13.
Yoo, H.S., Lee, E.A. and Park, T.G. (2002) Doxorubicin- conjugated biodegradable polymeric micelles having acid-cleavable linkages. J. Control. Release, 82, 17-27.
Xiao S.Y., Tong, C.Y., Liu, X.M., Yu, D.M., Liu, Q.L., Xue, C.G., Tang, D.Y. and Zhao, L.J. (2006) Preparation of folate-conjugated starch nanoparticles and its applica-tion to tumor-targeted drug delivery vector. Chin. Sci. Bull, 51, 1151-1155.
Pan, J. and Feng, S.S. (2008) Targeted delivery of pa clitaxel using folate-decorated poly(lactide)-vitaminE TPGS nan-oparticles. Biomaterials, 29, 2663-2672.
Terada, T., Iwai, M., Kawakami, S., Yamashita, F. and Hashida, M. (2006) Novel PEG-matrix metalloprotei- nase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective target-ing. J. Control. Release, 111, 333-342.
Sershen, S.R., Westcoot, S.L., Halas, N.J. and West, J.L. (2000) Temperature-sensitive polymer-nanoshell com-posites for photothermally modulated drug delivery. J. Biomed. Mater. Res., 51, 293-298.
Sun, Y., Lu, M. and Yin, X.F. (2006) Ntracellular deliv-ery of fluoresent dyes mediated by nanometer-liposomes. Chem. J. Chin. U., 27, 632-634.
Sivaramakrishnan, R., Nakamura, C., Mehnert, W., Kor- ting, H.C., Kramer, K.D. and Schafer-Korting, M. (2004) Glucocorticoid entrapment into lipid carriers-characteri- zation by parelectric spectroscopy and influence on der-mal uptake. J. Control. Release, 97, 493-502.
Ding, J.C., Hu, F.Q. and Yuan, H. (2004) Uptake of mono-stearin solid lipid nanoparticles by A549 cells. Acta Phamaceutica Sinica, 39, 876-880.
Pantarotto, D., Partidos, C.D., Hoebeke, J., Brown, F., Kramer, E., Briand, J.P., Muller, S., Prato, M. and Bianco, A. (2003) Mmunization with peptide-functionalized car-bon nanotubes enhances virus-specific neutralizing anti-body responses. Chem. Biol., 10, 961-966.