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Synthesis of 4-[F-18]Fluoro-4-Deoxy-<i>N</i>-Acetyl-1,3,6-Tri-<i>O</i>-Acetylglucosamine, a Potential Brain Imaging PET Agent
Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
Advion Biosciences, Ithaca, USA
Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
- 1 Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
- 2 Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
- 3 Advion Biosciences, Ithaca, USA
- 4 Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
- 5 Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA
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Abstract
The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-decay corrected radiochemical yield and purity were found to be 31% ± 4% (n = 3) and >98% respectively. The total reaction time for radio labelling step was 50 min.
KeywordsN-AcetylglucosamineAmyloidogenesisLipase-<i>Candida </i><i>r</i><i>ugosa</i>
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