Experimental and Computational Study of Amino Acid Synthesis from Acetonitrile and Glycine Oligomers on a Carbonate Surface under UV-C Radiation: Implications for Titan and Early Earth — Oak Academic Publishing
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Experimental and Computational Study of Amino Acid Synthesis from Acetonitrile and Glycine Oligomers on a Carbonate Surface under UV-C Radiation: Implications for Titan and Early Earth
Laboratorio de Evolución Química, Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Ciudad de México, México
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Laboratorio de Evolución Química, Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Ciudad de México, México
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The Network of Researchers on the Chemical Evolution of Life Institute (The NoRCEL Institute), Leeds, UK
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Sigma Xi, The Scientific Research Honor Society, North Carolina, USA
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Sociedad Mexicana de Astrobiología (SOMA), Ciudad de México, México
1 Laboratorio de Evolución Química, Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Ciudad de México, México
2 Laboratorio de Evolución Química, Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Ciudad de México, México
3 The Network of Researchers on the Chemical Evolution of Life Institute (The NoRCEL Institute), Leeds, UK
4 Sigma Xi, The Scientific Research Honor Society, North Carolina, USA
5 Sociedad Mexicana de Astrobiología (SOMA), Ciudad de México, México
This study investigates prebiotic chemistry on Titan and Early Earth using experimental methods, including Differential Scanning Calorimetry (DSC) and Fourier-Transform Infrared Spectroscopy (FTIR), which are relevant for identifying molecular structures and thermal stability of amino acids. Analyses of glycine and acetonitrile with calcium carbonate under UV-C radiation show that glycine oligomers facilitate stable amino acid synthesis. We conclude that Titan’s environment can directly support the formation of life-relevant molecules, revealing a plausible pathway for chemical evolution analogous to that on Early Earth.
Ángeles-Camacho, J., Morales, P., Pizarro, W., Macías, V. and Avalos, E. (2017) Los Aminoácidos en el cuerpo humano. RECIMUNDO : Revista Científica de la Investigación y el Conocimiento , 1, 379-391.
Herrera, A.L. (1942) A New Theory of the Origin and Nature of Life. Science , 96, 14. https://doi.org/10.1126/science.96.2479.14
Miller, S.L. (1953) A Production of Amino Acids under Possible Primitive Earth Conditions. Science , 117, 528-529. https://doi.org/10.1126/science.117.3046.528
Sousa, F.L., Thiergart, T., Landan, G., Nelson-Sathi, S., Pereira, I.A.C., Allen, J.F., et al. (2013) Early Bioenergetic Evolution. Philosophical Transactions of the Royal Society B : Biological Sciences , 368, Article ID: 20130088. https://doi.org/10.1098/rstb.2013.0088
Porco, C.C., Baker, E., Barbara, J., Beurle, K., Brahic, A., Burns, J.A., et al. (2005) Imaging of Titan from the Cassini Spacecraft. Nature , 434, 159-168. https://doi.org/10.1038/nature03436
Lunine, J.I. and Hörst, S.M. (2011) Organic Chemistry on the Surface of Titan. Rendiconti Lincei , 22, 183-189. https://doi.org/10.1007/s12210-011-0130-8
Edison, A.S. (2001) Linus Pauling and the Planar Peptide Bond. Nature Structural Biology , 8, 201-202. https://doi.org/10.1038/84921
Draganíc, I.G. (2000) The Role of Radiation in the Origin and Evolution of Life. Radiation Research , 154, 353-353. https://doi.org/10.1667/0033-7587(2000)154[0353:trorit]2.0.co;2
Spinks, J.W.T. and Woods, R.J. (1990) An Introduction to Radiation Chemistry. 3rd Edition, Wiley.
Angeles-Camacho, E., Cruz-Castañeda, J., Meléndez, A., Colín-García, M., Cruz, K.C.d.l., Ramos-Bernal, S., et al. (2020) Potential Prebiotic Relevance of Glycine Single Crystals Enclosing Fluid Inclusions: An Experimental and Computer Simulation with Static Magnetic Fields. Advances in Biological Chemistry , 10, 140-156. https://doi.org/10.4236/abc.2020.105011
Powner, M.W., Gerland, B. and Sutherland, J.D. (2009) Synthesis of Activated Pyrimidine Ribonucleotides in Prebiotically Plausible Conditions. Nature , 459, 239-242. https://doi.org/10.1038/nature08013
Coustenis, A. (2016) Titan’s Organic Chemistry: A Planetary-Scale Laboratory to Study Primitive Earth. Metode Science Studies Journal , No. 6, 175-181. https://doi.org/10.7203/metode.6.4999
Li, Y. (2022) Minerals as Prebiotic Catalysts for Chemical Evolution Towards the Origin of Life. In: René, M., Ed., Mineralogy , IntechOpen, 1-18. https://doi.org/10.5772/intechopen.102389
Oosawa, F. and Hayashi, S. (1986) The Loose Coupling Mechanism in Molecular Machines of Living Cells. Advances in Biophysics , 22, 151-183. https://doi.org/10.1016/0065-227x(86)90005-5
Cepelewicz, J. (2017) Life’s First Molecule Was Protein, Not RNA, New Model Suggests. Quanta Magazine. https://www.scientificamerican.com/article/life-rsquo-s-first-molecule-was-protein-not-rna-new-model-suggests/
Raulin, F. (2014) Tholins. In: Amils, R., et al ., Eds., Encyclopedia of Astrobiology , Springer, 1-4. https://doi.org/10.1007/978-3-642-27833-4_1588-4
Cunha de Miranda, B., Garcia, G.A., Gaie-Levrel, F., Mahjoub, A., Gautier, T., Fleury, B., et al. (2016) Molecular Isomer Identification of Titan’s Tholins Organic Aerosols by Photoelectron/Photoion Coincidence Spectroscopy Coupled to VUV Synchrotron Radiation. The Journal of Physical Chemistry A , 120, 6529-6540. https://doi.org/10.1021/acs.jpca.6b03346
Waite, J.H., Young, D.T., Cravens, T.E., Coates, A.J., Crary, F.J., Magee, B., et al. (2007) The Process of Tholin Formation in Titan’s Upper Atmosphere. Science , 316, 870-875. https://doi.org/10.1126/science.1139727
Ida, N. (2004) Engineering Electromagnetics. 2nd Edition, Springer.
Keszthelyi, S., Gibicsar, S., Binder, A., Somfalvi-Tóth, K. and Pál-Fám, F. (2024) Impact of UV-C Irradiation on Storage Pests with Different Ecological Functions and the Viability of the Treated Grains. Journal of Plant Protection Research , 64, 384-393. https://doi.org/10.24425/jppr.2024.152885
Sulaiman, A.H., Achilleos, N., Bertucci, C., Coates, A., Dougherty, M., Hadid, L., et al. (2021) Enceladus and Titan: Emerging Worlds of the Solar System. Experimental Astronomy , 54, 849-876. https://doi.org/10.1007/s10686-021-09810-z
Marty, B. (2012) The Origins and Concentrations of Water, Carbon, Nitrogen and Noble Gases on Earth. Earth and Planetary Science Letters , 313, 56-66. https://doi.org/10.1016/j.epsl.2011.10.040
Saxena, P.P. (2007) On the Possibility of Gly and Ala Amino Acids on Titan. Bulletin of the Astronomical Society of India , 35, 15-21. http://www.ncra.tifr.res.in/~basi/07March/35152007.pdf
Cable, M.L., Vu, T.H., Malaska, M.J., Maynard-Casely, H.E., Choukroun, M. and Hodyss, R. (2020) Properties and Behavior of the Acetonitrile-Acetylene Co-Crystal under Titan Surface Conditions. ACS Earth and Space Chemistry , 4, 1375-1385. https://doi.org/10.1021/acsearthspacechem.0c00129
Coustenis, A. (2014) Titan. In: Spohn, T., Breuer, D. and Johnson, T.V., Eds., Encyclopedia of the Solar System , Elsevier, 831-849. https://doi.org/10.1016/b978-0-12-415845-0.00038-4
McKee, T. (2014) Bioquímica, las bases moleculares de la vida, Cuarta. McGraw-Hill.
Lunine, J.I. (2009) Titan as an Analog of Earth’s Past and Future. The European Physical Journal Conferences , 1, 267-274. https://doi.org/10.1140/epjconf/e2009-00926-7
Cnossen, I., Sanz‐Forcada, J., Favata, F., Witasse, O., Zegers, T. and Arnold, N.F. (2007) Habitat of Early Life: Solar X‐Ray and UV Radiation at Earth’s Surface 4-3.5 Billion Years Ago. Journal of Geophysical Research : Planets , 112, E02008. https://doi.org/10.1029/2006je002784
Mitchell, K.L. , et al. (2008) What Is Infrared Spectroscopy? Fundamentals & Applications. Geophysical Research Letters , 35, 2007GL032118.
Neish, C.D., Kirk, R.L., Lorenz, R.D., Bray, V.J., Schenk, P., Stiles, B.W., et al. (2013) Crater Topography on Titan: Implications for Landscape Evolution. Icarus , 223, 82-90. https://doi.org/10.1016/j.icarus.2012.11.030
Fried, S.D., Fujishima, K., Makarov, M., Cherepashuk, I. and Hlouchova, K. (2022) Peptides before and during the Nucleotide World: An Origins Story Emphasizing Cooperation between Proteins and Nucleic Acids. Journal of The Royal Society Interface , 19, Article ID: 20210641. https://doi.org/10.1098/rsif.2021.0641
Polanski, J. (2009) Chemoinformatics. In: Brown, S.D., Tauler, R. and Walczak, B., Eds., Comprehensive Chemometrics , Elsevier, 459-506. https://doi.org/10.1016/b978-044452701-1.00006-5
Sandoval Quintana, A., Rodriguez Sandoval, E. and Fernandez Quintero, F. (2005) Aplicación del análisis por calorimetría diferencial de barrido (DSC) para la caracterización de las modificaciones del almidón. Dyna , 72, 45-53.
Schrader, B. (1995) Infrared and Raman Spectroscopy: Methods and Applications. Wiley.
Rieppo, L., Saarakkala, S., Närhi, T., Helminen, H.J., Jurvelin, J.S. and Rieppo, J. (2012) Application of Second Derivative Spectroscopy for Increasing Molecular Specificity of Fourier Transform Infrared Spectroscopic Imaging of Articular Cartilage. Osteoarthritis and Cartilage , 20, 451-459. https://doi.org/10.1016/j.joca.2012.01.010
Roy, S., Chatterjee, A., Bal, S. and Das, D. (2022) Cross β Amyloid Nanotubes Demonstrate Promiscuous Catalysis in a Chemical Reaction Network via Co‐Option. Angewandte Chemie International Edition , 61, e202210972. https://doi.org/10.1002/anie.202210972