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Fluorine-18 Radiochemistry: A Novel Thiol-Reactive Prosthetic Group, [18F]FBAMPy
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
- 1 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
- 2 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
- 3 Departments of Chemistry and Radiology, University of Tennessee, Knoxville, TN, USA
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Abstract
A novel thiol-reactive bifunctional agent, an analogue of fluorobenzaldehyde-O-[6-(2,5-dioxo-2,5- dihydro-pyrrol-1-yl)-hexyl]oxime, (FBAM) has been synthesized. The new prosthetic group, [18F]- FBAMPy, replaces the 4-fluorophenyl moiety with a 2-fluoropyridinyl moiety leading to increased polarity (FBAM analytical HPLC R f = 6.4 min; FBAMPy R f = 4.8 min) while retaining the sulfur-reactive pendant. By altering the polarity of the molecule, this new prosthetic group should have significant impact in coupling it with small peptides and other biomolecules.
KeywordsRadiochemistryProsthetic GroupPETFluorine-18
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