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Effect of Added Cu(OTf)<sub>2</sub> on the Cu(OTf)<sub>2</sub>(Py)<sub>4</sub>-Mediated Radiofluorination of Benzoyl and Phthaloylglycinates
Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA
- 1 Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
- 2 Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
- 3 Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
- 4 Department of Radiology, University of Tennessee Medical Center, Knoxville, Tennessee, USA
- 5 Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA
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Abstract
Cu(OTf) 2 (Py) 4 mediated radiofluorination of the boronate esters of ethyl benzoyl and phthaloylglycinates (11 and 16) using 10 mol% of the copper complex following the literature procedure did not provide the fluorinated products. However, the addition of Cu(OTf) 2 resulted in the radio-fluorination of the boronate esters 11 and 16 to obtain ethyl 4-[ 18 F]fluorobenzoyl glycinate, 17, (48%) and ethyl 3-[ 18 F]phthaloylglycinate (41%) respectively.
KeywordsGlycinatesBoronate EstersGorlos-PhosRadiofluorinationCopper Triflate
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