Ki67 is a marker of cell proliferation that is expressed in the S, G2 and M phases but not in the G0 phase of the cell cycle. Several recent studies showed that the expression of Ki67 is closely related to the occurrence and development of gastrointestinal tumours. The Ki67 index is closely related to the degree of differentiation, invasion, metastasis and prognosis of gastrointestinal tumours. This review describes the relationship between the Ki67 index and degree of malignancy, therapeutic effect and prognosis of gastrointestinal tumours.
Gerdes, J., Schwab, U., Lemke, H., et al. (1983) Production of a Mouse Monoclonal Antibody Reactive with a Human Nuclear Antigen Associated with Cell Proliferation. International Journal of Cancer, 31, 13-20. https://doi.org/10.1002/ijc.2910310104
Gerdes, J., Li, L., Schlueter, C., et al. (1991) Immunobiochemical and Molecular Biologic Characterization of the Cell Proliferation-Associated Nuclear Antigen that Is Defined by Monoclonal Antibody Ki-67. The American Journal of Pathology, 138, 867-873.
Ohashi, R., Namimatsu, S., Sakatani, T., et al. (2018) Prognostic Utility of Atypical Mitoses in Patients with Breast Cancer: A Comparative Study with Ki67 and Phosphohistone H3. Journal of Surgical Oncology, 118, 557-567. https://doi.org/10.1002/jso.25152
Zhang, C. and Qian, J. (2018) Research Progress on the Correlation between Ki67 and Tumor. Journal of Qiqihar Medical University, 39, 2536-2538.
Sang, D., Wang, J. and Xu, B. (2015) Relationship between Proliferating Cell Nuclear Antigen Ki67 and Curative Effect of Neoadjuvant Chemotherapy for Breast Cancer. Chinese Journal of Breast Disease (Electronic Edition), 9, 50-53.
Pathmanathan, N. and Balleine, R.L. (2013) Ki67 and Proliferation in Breast Cancer. Journal of Clinical Pathology, 66, 512-516.
Chen, Q. and Wu, K. (2015) Research Progress on the Clinical Value of Ki-67 Breast Cancer and Its Critical Value Definition. Chinese Journal of Surgery, 53, 634-637.
Qian, X., Cai, J., Zhao, J., et al. (2019) Expression and Significance of EBER, Ki67 and BCL2 in Nasal NK/T Lymphoma. Journal of Nantong University (Medical Sciences), 39, 523-525.
He, H., Chai, X., Xu, W., et al. (2020) Relationship between PD-L1, Ki67 and Clinicopathological Features and Prognosis of Patients with Non-Small Cell Lung Cancer. China Journal of Modern Medicine, 30, 39-44.
Zhang, Y., Li, Q., Li, H., et al. (2019) Meta Analysis of the Prognostic Significance of Ki67 Expression Ratio in Breast Cancer Patients. Journal of Modern Oncology, 30, 1890-1894.
Zheng, C., Wang, Y. and Lu, W. (2021) Diagnostic Value of Serum HE4 and Ki67 Levels in Patients with Ovarian Cancer and Their Relationship with Clinicopathological Features and Prognosis. Chinese Journal of Human Sexuality, 25, 45-49.
Cao, Q. (2021) Expression of Serum VEGF, PD-L1 and Ki67 in Patients with Cervical Cancer and Its Prognostic Value. Chinese Journal of Public Health Engineering, 25, 256-258.
Huang, T., Liu, J., Zhang, J., et al. (2019) The Role of Ki67 in Predicting the Prognosis of Prostate Cancer. National Journal of Andrology, 25, 1088-1092.
World Health Organization (WHO) (2020) Global Health Estimates.
Zuo, T., Zheng, R., Zeng, H., et al. (2017) Epidemiological Status of Gastric Cancer in China. Chinese Journal of Clinical Oncology, 44, 52-58.
Xue, W., Fan, X. and Meng, G. (2014) Expert Consensus on the Selection of Immunohistochemical Markers Related to Gastric Cancer. Chinese Journal of Clinical and Experimental Pathology, 30, 951-953.
Qiu, H. and Zhou, Z. (2018) Updates and Interpretation on NCCN Clinical Practice Guidelines for Gastric Cancer 2017 Version 5. Chinese Journal of Gastrointestinal Surgery, 21, 160-164.
Wang, Y. (2021) Positive Expression of Ki67, EGFR and p53 in Gastric Cancer and Its Clinical Significance. Clinical Medicine & Engineering, 28, 595-596.
Zhao, S., Chen, Y., Li, H., et al. (2020) Correlation between Transcription Factor Foxq1 and Proliferation Index Ki67 in Advanced Gastric Cancer. Medical Journal of Communications, 34, 349-353.
Yao, Q., Wang, J., Li, H., et al. (2021) Expression of NEDD9, CD44 and Ki67 in Gastric Cancer and Their Relationship with Clinicopathological Features. Journal of Modern Oncology, 29, 2863-2867.
Chen, T., Chen, Y., Wu, J., et al. (2020) Expression of FOXP1 and Ki67 in Advanced Gastric Cancer and Their Effect on Prognosis. Journal of Nanjing Medical University (Natural Sciences), 40, 1181-1185, 1240.
Jiang, S., Sun, D. and Xin, Y. (2019) Expression of WISP1 and Ki67 in Gastric Cancer and their Clinicopathological Significance. Journal of Modern Oncology, 27, 256-261.
Zhou, Y., Chen, X. and Ding, H. (2016) Expression of TRAP1, Ki67 and AFP in Patients with Gastric Cancer and Their Combined Value in Predicting Liver Metastasis of Gastric Cancer. The Practical Journal of Cancer, 31, 1412-1413.
Hua, Y. (2015) Correlation between Ki67 Expression and Chemosensitivity of Fluorouracil in Gastric Cancer. In: Shi, Y.K., Ed., the 9th Chinese Symposium on Medical Oncology, CSMO, the 4th Annual Meeting of Chinese Society for Clinical Oncologists, CACO, Proceedings of 2015 Academic Annual Meeting of Tumor Clinical Chemotherapy Professional Committee of China Anti Cancer Association, Peking Union Medical College Press, Beijing, 770-771.
Cao, M. and Chen, W. (2021) Interpretation of GLOBOCAN 2020 Global Cancer Statistics. Chinese Journal of the Frontiers of Medical Science (Electronic Version), 13, 63-69.
Hoshino, N., Hasegawa, S., Hida, K., et al. (2016) Nomogram for Predicting Recurrence in Stage II Colorectal Cancer. Acta Oncologica, 55, 1414-1417. https://doi.org/10.1080/0284186X.2016.1223881
de Sousa, W.A.T., Rodrigues, L.V., da Silva, R.G., et al. (2012) Immunohistochemical Evaluation of p53 and Ki-67 Proteins in Colorectal Adenomas. Arquivos de Gastroenterologia, 49, 35-40. https://doi.org/10.1590/S0004-28032012000100007
Li, H., Zheng, Y., Cheng, H., et al. (2021) Expression of Tumor Markers and Ki67 in Colorectal Cancer and Analysis of Prognostic Factors. Journal of Abdominal Surgery, 34, 110-114.
Wang, X., Jin, L., Zhang, Y., et al. (2019) Expression of rpn11 and Ki67 in Colorectal Cancer and Their Clinicopathological Significance. Chinese Journal of Histochemistry and Cytochemistry, 28, 247-251.
Tong, G., Zhang, G., Liu, J., et al. (2020) Cutoff of 25% for Ki67 Expression Is a Good Classification Tool for Prognosis in Colorectal Cancer in the AJCC-8 Stratification. Oncology Reports, 43, 1187-1198. https://doi.org/10.3892/or.2020.7511
Wei, X., Bu, J. and Mo, X. (2018) The Prognostic Significance of FBXO2 Expression in Colorectal Cancer. International Journal of Clinical and Experimental Pathology, 11, 5054-5062.
Zhao, W., Lv, L., Qi, X., et al. (2016) Correlation between the Expression of CD147 and Ki67 in Hepatocellular Carcinoma and Its Clinical Significance. Military Medical Journal of South China, 30, 700-704.
Chen, W. (2020) Diagnostic Value of Ki-67 and Ezrin Protein in Pathology of Primary Liver Cancer. Jilin Medical Journal, 41, 294-295.
Zhang, X., Wu, Z.X., Peng, Y.H., et al. (2021) Correlationship between Ki67, VEGF, p53 and Hepatocellular Carcinoma Recurrence in Liver Transplant Patients. BioMed Research International, 2021, Article ID: 6651397. https://doi.org/10.1155/2021/6651397
Guo, F., Yang, J., Xiong, S., et al. (2018) Expression of Drug Resistance Gene Protein and Ki67 in Primary Liver Cancer and Its Prognostic Value. Chinese Journal of Hepatic Surgery (Electronic Edition), 7, 77-81.
Jia, L., Li, H., Bai, H., et al. (2020) The Expression of CD34 and Ki67 Predicts the Risk of Postoperative Recurrence of Hepatocellular Carcinoma. Chinese Hepatology, 25, 197-199.
Chen, W.Q., Zheng, R.S., Zeng, H.M., et al. (2016) The Incidence and Mortality of major Cancers in China, 2012. Chinese Journal of Cancer, 35, Article No. 73. https://doi.org/10.1186/s40880-016-0137-8
Siegel, R.L., Miller, K.D. and Jemal, A. (2019) Cancer Statistics, 2019. CA: A Cancer Journal for Clinicians, 69, 7-34. https://doi.org/10.3322/caac.21551
Wang, H., Zhou, Y., Liu, Q., et al. (2018) Prognostic Value of SOX2, Cyclin D1, P53, Ki-67 in Patients with Esophageal Squamous Cell Carcinoma. OncoTargets and Therapy, 11, 5171-5181. https://doi.org/10.2147/OTT.S160066
He, X., Ma, R., Jia, W., et al. (2020) Expression and Clinical Significance of S100A8 and Ki67 Proteins in Esophageal Carcinoma. Labeled Immunoassays and Clinical Medicine, 27, 989-992, 995.
Qi, X., Qiu, Y., Chen, D., et al. (2019) Expression of Ki-67 and VEGF in Esophageal Carcinoma and Their Relationship with Radiotherapy Prognosis. Chinese Journal of Clinical Rational Drug Use, 12, 44-46, 48.
Zhao, L., Chu, X., Li, S., et al. (2021) Expression and Significance of Ki-67 in Basal Cell Like Squamous Cell Carcinoma of Esophagus. People’s Military Surgeon, 64, 446-449.
Jacobsen, F., Kohsar, J., Gebauer, F., et al. (2020) Loss of p16 and High Ki67 Labeling Index Is Associated with Poor Outcome in Esophageal Carcinoma. Oncotarget, 11, 1007-1016. https://doi.org/10.18632/oncotarget.27507
Deng, H.Y., Chen, Z.H., Wang, Z.Q., et al. (2017) High Expression of Ki-67 Is an Independent Favorable Prognostic Factor for Esophageal Small Cell Carcinoma. Oncotarget, 8, 55298-55307. https://doi.org/10.18632/oncotarget.19426