Epidemiological, Clinical, Paraclinical, Etiological and Therapeutic Aspects of Liver Cirrhosis in the Hepato-Gastroenterology Department of the Hospital Aristide Le Dantec in Dakar
- 1 Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal
- 2 Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal
- 3 Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal
- 4 Department of Gastroenterology and Hepatology, Peace Hospital, Ziguinchor, Senegal
- 5 Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal
- 6 Department of Gastroenterology and Hepatology, Hospital Aristide Le Dantec, Dakar, Senegal
- 7 Department of Gastroenterology and Hepatology, Hospital Idrissa Pouye, Dakar, Senegal
Abstract
Introduction: Liver cirrhosis is a global public health issue. Our aim was to determine the epidemiological, clinical, paraclinical and therapeutic aspects of liver cirrhosis in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. Patients and Methods: We conducted a retrospective study with a descriptive focus covering the period from January 1st, 2010 to December 31, 2020. We included the medical records of patients which presented body of clinical and paraclinical arguments which supported the diagnosis of cirrhosis. The data collected were related to age, gender, clinical, paraclinical, therapeutic and prognosis aspects of cirrhosis and were analyzed with the software Sphinx Plus. Results: Prevalence of cirrhosis was 6.2%. Sex ratio was 2.1%. The average age was 38 years. Asthenia (60.9%), altered performance status (60.1%), abdominal pain (37.2%), gastrointestinal bleeding (29.6%) and abdominal swelling (27.8%) were the most common motives of consultation. Physical examination revealed primarily portal hypertension (74.9%), liver failure (2.4%), hepatomegaly (28.2%) and anemia (13.7%). Viral hepatitis B was the most common etiology (81.9%). Abdominal screening (ultrasound/CT scan) showed hepatomegaly (80.6%), liver dysmorphia (87.7%), portal hypertension signs (85.3%) and portal vein thrombosis (18.2%). 55.1% Patients were classified as Child Pugh A, 33.8% were Child Pugh B and 11.1% were Child Pugh C. Tenofovir Disoproxil Fumarate (TDF) was prescribed to all patients affected by hepatitis B virus only. Evolution was characterized by clinical improvement and prognosis reclassification. Conclusion: Liver cirrhosis is a frequent pathology in the hepato-gastroenterology department of the hospital Aristide Le Dantec in Dakar. It affects young male adult. Hepatitis B virus is the leading cause. TDF is an effective treatment.
- Di Martino, V. and Weil-Verhoeven, D. (2020) Prise en charge et surveillance de la cirrhose. EMC-Hépatologie, 35, 1-15.
- Bernsmeiera, P.C. and De Gottardib, A. (2018) Hépatologie: La cirrhose hépatique n’est plus ce qu’elle était! Forum Médical Suisse, 18, 1090-1092. https://doi.org/10.4414/fms.2018.08015
- Hytiroglou, P., Snover, D.C., Alves, V., Balabaud, C., Bhathal, P.S., Bioulac-Sage, P., et al. (2012) Beyond “Cirrhosis”: A Proposal from the International Liver Pathology Study Group. American Journal of Clinical Pathology, 137, 5-9. https://doi.org/10.1309/AJCP2T2OHTAPBTMP
- Mokdad, A.A., Lopez, A.D., Shahraz, S., Lozano, R., Mokdad, A.H., Stanaway, J., et al. (2014) Liver Cirrhosis Mortality in 187 Countries between 1980 and 2010: A Systematic Analysis. BMC Medicine, 12, Article No. 145. https://doi.org/10.1186/s12916-014-0145-y
- Sadaf, S., Saeid, S., Catherine, B. and Kevin, I. (2020) The Global, Regional, and National Burden of Cirrhosis by Cause in 195 Countries and Territories, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study. The Lancet Gastroenterology and Hepatology, 5, 245-266. https://doi.org/10.1016/S2468-1253(19)30349-8
- Dia, D., Diouf, G., Gueye, M.N., Cissé, C.A.B., Cissé, M., et al. (2019) Clinical, Paraclinical and Etiological Aspects of Cirrhosis in a Department of Internal Medicine in Senegal. Advanced Research in Gastroenterology & Hepatology, 12, Article ID: 555836. https://doi.org/10.19080/argh.2019.12.555836
- Nagaonlé Somé, E., Guingané, N.A., Télarpoa Lompo, I. and Sombié, R. (2021) Cirrhose du foie: Aspects épidémiologiques et diagnostiques au centre hospitalier universitaire Yalgado Ouédraog. Revue Africaine des Sciences Sociales et de la Santé Publique, 3, 54-64.
- Sehonou, J., Kodjoh, N., Sake, K. and Mouala, C. (2010) Cirrhose hépatique à Cotonou (République du Bénin): Aspects cliniques et facteurs liés au décès. Médecine Tropicale, 70, 375-378.
- Bouglouga, O., Bagny, A. and Djibril, A. (2012) Aspects épidémiologique, clinique et évolutif de la cirrhose du CHU Campus de Lomé. Journal de la Recherche Scientifique de l’Université de Lomé, 14, 1-7.
- Doffou, A.S., Bangoura, A.D., Kouamé, G.D., Yaogo, A., Meite, M., Kissi, H. and Attia, K.A. (2019) La cirrhose alcoolique chez le noir africain au centre hospitalier universitaire de Yopougon: Caractéristiques épidémiologiques, cliniques et biologiques. Revue Internationale des Sciences Médicales d’Abidjan-RISM, 21, 212-218.