Seroprevalence, Importance of Rapid Testing and Factors Associated with HBsAg Carriage in Pregnancy in Three Referral Maternity Hospitals in Mono (Benin), in 2020 — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
Seroprevalence, Importance of Rapid Testing and Factors Associated with HBsAg Carriage in Pregnancy in Three Referral Maternity Hospitals in Mono (Benin), in 2020
Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Republic of Benin
,
Hepato-Gastroenterology Department, National and University Hospital Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Repub-lic of Benin
,
Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
,
Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
,
Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Republic of Benin
,
Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
1 Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Republic of Benin
2 Hepato-Gastroenterology Department, National and University Hospital Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Repub-lic of Benin
3 Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
4 Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
5 Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Republic of Benin
6 Obstetrics Gynecology Department, Lagune Mother-Child University Hospital Center (CHU MEL), Cotonou, Republic of Benin
Introduction Difficulties in accessing the screening test for viral hepatitis B in maternity wards could be a factor in underestimating the prevalence of anti-HBV antibodies. The rapid diagnostic orientation test (RDOT) could improve seroprevalence and obstetrical prognosis. The aim of this study was to use the rapid diagnostic orientation test (RDOT) to determine the seroprevalence of HBs antigen carriage in pregnant women while highlighting the associated factors. Methods This was a cross-sectional and descriptive study that took place from October to December 2020 (three months) in three (03) reference maternities in western Benin (Mono). Consenting pregnant women received in prenatal consultation had been screened by RDOT. Positive cases were confirmed by ELISA test. The follow-up of these cases made it possible to establish the obstetrical prognosis. Results Of 201 women studied, 11 (5.5%) were positive for RDOT HBV and confirmed by the ELISA test. The factors associated with HBsAg carriage during pregnancy were multiple sexual partnerships (p = 0.01), female circumcision (p = 0.0001), and ignorance of prior HBV serological status (p = 0.0001). No influence of hepatitis B on pregnancy was noted. Conclusion The seroprevalence of hepatitis B in pregnancy was intermediate in the reference maternities of western Benin. The associated factors were multiple sexual partnerships, female circumcision and unawareness of prior HBV status. Free RDOT in maternity wards would improve early detection and management of viral hepatitis B in pregnancy.
Organisation Mondiale de la santé (2016) Stratégie mondiale du secteur de la sante contre l’hépatite virale, 2016-2021. Genève, 55 p.
Omatola, C.A., Lawal C., Omosayin, D.O., et al. (2019) Seroprevalence of HBV, HCV, and HIV and Associated Risk Factors among Apparently Healthy Pregnant Women in Anyigba, Nigeria. Viral Immunology, 32, 186-191. https://doi.org/10.1089/vim.2018.0140
Sogni, P. (2015) Grossesse et hépatites virales B et C. Presse Médicale, 44, 654-659. https://doi.org/10.1016/j.lpm.2015.04.018
Kpossou, A.R, Aguemon, C.T., Dougnon, F.F., et al. (2018) Carriage of HBsAg in Pregnant Women at the University Clinic of Obstetric Gynecology of Cotonou, Benin: Prevalence and Associated Factors. Journal of Gastroenterology and Hepatology, 2, 44-46.
Kodjoh, N., Anani, L., Azon-Kouanou, A., et al. (2011) Prévalence de l’hépatite B chez les nouveaux donneurs de sang dans les départements du Mono et du Couffo au Bénin. Le Bénin Médical, 47, 29-31.
Kouakou, C., Dainguy, M.E., Djoman, A., et al. (2020) Transmission mère-enfant des marqueurs du virus de l’Hépatite B dans un hôpital de référence en Côte d’Ivoire. Mali Medical, 35, 43-46.
Fiacre, S.A., Bagnaka, E., Simo, V.M., et al. (2020) Evaluation de la Prévention de la Transmission Mère-Enfant du virus de l’hépatite B dans un pays à haute endémicité: Cas de la maternité principale de Yaoundé au Cameroun. Revue de Médecine et de Pharmacie, 10, 1062-1073.
Alassan, K.S., Imorou, R.S., Sonombiti, H., et al. (2019) Séroprévalence et facteurs associés à l’hépatite virale B chez les gestantes à Parakou en République du Bénin. Pan African Medical Journal, 33, Article No. 226. https://doi.org/10.11604/pamj.2019.33.226.19429
Kodjoh, N. (2015) Situation de la lutte contre les hépatites virales B et C en Afrique. Médecine et Santé Tropicales, 25, 141-144. https://doi.org/10.1684/mst.2015.0439
Aboubakar, M., Kpossou, A.R., Glago, B.R.G.H., et al. (2020) Prévalence et facteurs associés au portage des anticorps antiVHC chez des femmes enceintes à Cotonou. Pan African Medical Journal, 36, Article No. 182. https://doi.org/10.11604/pamj.2020.36.182.23122
De Paschale, M., Ceriani, C., Cerulli, T., et al. (2014) Prevalence of HBV, HDV, HCV, and HIV Infection during Pregnancy in Northern Benin. Journal of Medical Virology, 86, 1281-1287. https://doi.org/10.1002/jmv.23951
Sbiti, M., Khalki, H., Benbella, I., et al. (2016) Séroprévalence de l’AgHBs chez la femme enceinte dans le centre du Maroc. Pan African Medical Journal, 24, Article No. 187. https://doi.org/10.11604/pamj.2016.24.187.9849
Traoré, A. (2020) L’infection par le virus de l’hépatite B chez la femme enceinte au service de gynécologie-obstétrique du CHU Gabriel Touré. Thèses, Université des sciences des techniques et des technologies de Bamako (Mali), Faculté de Médecine et d’Odonto-Stomatologie, Bamako Mali, 81 p.
Zeba, M.T.A., Karou, S.D., Sagna, T., et al. (2011) HCV Prevalence and Co-Infection with HIV among Pregnant Women in Saint Camille Medical Centre, Ouagadougou: HCV Prevalence and Co-Infection with HIV in Ouagadougou. Tropical Medicine & International Health, 16, 1392-1396. https://doi.org/10.1111/j.1365-3156.2011.02845.x
Ousmane, A., Alhousseyni, M.D., Laouali, H.A.M., et al. (2018) Facteurs de risque et prévalence de l’antigène HBs chez les femmes enceintes et leurs nouveau-nés à Niamey au Niger. Health Sciences, 19, 27-31.
Ejeta, E. and Dabsu, R. (2019) Prevalence of Hepatitis C Virus and HIV Infection among Pregnant Women Attending Antenatal Care Clinic in Western Ethiopia. Frontiers in Medicine, 5, Article No. 366. https://doi.org/10.3389/fmed.2018.00366
Sirilert, S., Traisrisilp, K., Sirivatanapa, P., et al. (2014) Pregnancy Outcomes among Chronic Carriers of Hepatitis B Virus. International Journal of Gynecology & Obstetrics, 126, 106-110. https://doi.org/10.1016/j.ijgo.2014.02.019
Cai, Q., Liu, H., Han, W., et al. (2019) Maternal HBsAg Carriers and Adverse Pregnancy Outcomes: A Hospital-Based Prospective Cohort Analysis. Journal of Viral Hepatitis, 26, 1011-1018. https://doi.org/10.1111/jvh.13105
Abulude, O., Ismai’la, A. and Umar, S. (2019) Comparative Evaluation of Chromatographic Immunoassay and Enzyme-Linked Immunosorbent Assay in the Diagnosis of Hepatitis B Viral Infection in Pregnancy. ARC Journal of Hematology, 4, 28-34.
Fouelifack, F.Y., Fouedjio, J.H., Fouogue, J.T., et al. (2018) Seroprevalences and Correlates of Hepatitis B and C among Cameroonian Pregnant Women. Clinical Medicine Insights: Reproductive Health, 12, 1-6. https://doi.org/10.1177/1179558118770671
Luuse, A., Dassah, S., Lokpo, S., et al. (2017) Sero-Prevalence of Hepatitis B Surface Antigen amongst Pregnant Women Attending an Antenatal Clinic, Volta Region, Ghana. Journal of Public Health in Africa, 7, 81-83. https://doi.org/10.4081/jphia.2016.584
Bigot, K.A., Kodjoh, N., Zohoun, I.S., et al. (1992) Séroprévalence de l’antigène HBs du virus de l’hépatite chez les femmes enceintes et leurs enfants. Médecine d’Afrique Noire, 39, 487-490.
Sidibe, S., Sacko, B.Y. and Traoré, I. (2001) Prévalence des marqueurs sérologiques du virus de l’hépatite B chez les femmes enceintes dans le district de Bamako, Mali. Bulletin de la Société de Pathologie Exotique, 94, 339-341.
Ngaira, J.A.M., Kimotho, J., Mirigi, I., et al. (2016) Prevalence, Awareness and Risk Factors Associated with Hepatitis B Infection among Pregnant Women Attending the Antenatal Clinic at Mbagathi District Hospital in Nairobi, Kenya. Pan African Medical Journal, 24, Article No. 315. https://doi.org/10.11604/pamj.2016.24.315.9255
Yohanes, T., Zerdo, Z. and Chufamo, N. (2016) Seroprevalence and Predictors of Hepatitis B Virus Infection among Pregnant Women Attending Routine Antenatal Care in Arba Minch Hospital, South Ethiopia. Hepatitis Research and Treatment, 2016, Article ID: 9290163. https://doi.org/10.1155/2016/9290163
Murad, E.A., Babiker, S.M., Gasim, G.I., et al. (2013) Epidemiology of Hepatitis B and Hepatitis C Virus Infections in Pregnant Women in Sana’a, Yemen. BMC Pregnancy Childbirth, 13, Article No. 127. https://doi.org/10.1186/1471-2393-13-127
Mve Koh, V., Wambo Nguessi, C., Essiben, F., et al. (2019) Facteurs Associés au Portage de l’Ag HBbs en grossesse dans un pays de Haute Endémicité: Une étude Cas-Témoin. Health Sciences and Diseases, 20, 1-7.