Research ArticleOpen AccessGoogle Scholar indexed
Chronic Hepatitis B Virus Infection: Biological Parameters in Patients Treated with Tenofovir Disoproxil Fumarate
Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Unit, Csref Commune V, Bamako, Mali
Hepato-Gastroenterology Unit, Csref Commune V, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 1 Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
- 2 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 3 Hepato-Gastroenterology Unit, Csref Commune V, Bamako, Mali
- 4 Hepato-Gastroenterology Unit, Csref Commune V, Bamako, Mali
- 5 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 6 Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
- 7 Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
- 8 Hepato-Gastroenterology Department, Centre Hospitalier Universitaire Du Point G, Bamako, Mali
- 9 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 10 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 11 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 12 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
- 13 Hepato-Gastroenterology Department, Gabriel Toure University Hospital, Bamako, Mali
Open Journal of Gastroenterology·Volume 14 (2024)·Pages 145–151·Published 7 April 2024·DOI10.4236/ojgas.2024.144016
Copy link · social · email
Abstract
Chronic hepatitis B causes a liver disease characterized by inflammation of the liver parenchyma. The aim of this study was to investigate the evolution of biological parameters in patients treated with Tenofovir for chronic B infection at the Commune V referral health center in Bamako. We obtained a prevalence of 14.15%. The most represented age group was 31 - 40 years, with 36.8%. The sex ratio was 1.44 in favour of men. Viral load was undetectable after 18 months of treatment in 25 patients (42.37%). Tenofovir, the 1st-line drug in Mali, is effective on the biological parameters monitored in patients.
KeywordsViral Hepatitis BTenofovirBiological Parameters
- Zeitoun, J.-D., Ariane, C. and Jérémie, L. (2017) IKB Hépatologie Gastrologie Entérologie Chirurgie Viscérale. 6th Edition, Vemazobres-Grego, Paris.
- Dusheiko, G., Agarwal, K. and Maini, M.K. (2023) New Approaches to Chronic Hepatitis B. The New England Journal of Medicine , 388, 55-69. https://doi.org/10.1056/NEJMra2211764 https://www.nejm.org/doi/pdf/10.1056/NEJMra2211764?articleTools=true
- Kabore, H.J., Li, X., Alleman, M.M., Manzengo, C.M., Mumba, M., Biey, J., et al . (2023) Progress towards Hepatitis B Control and Elimination of Mother-to-Child Transmission of Hepatitis B Virus—WHO African Region, 2016-2021. Morbidity and Mortality Weekly Report ( MMWR ), 72, 782-787. https://doi.org/10.15585/mmwr.mm7229a2
- Illa, H., Stanislas, D.A., Dimitri, K.H., Aboubacar, B.D., Abdelatif, Y., Henriette, K., Mahassadi, A.K., Fulgence, Y.B. and Alain, A.K. (2023) Prévalence de l’infection par l’hépatite virale B et facteurs associes chez les enfants des sujets ivoiriens porteurs de l’AgHBs. Mali Mé dical , XXXVIII, 16-20. https://www.researchgate.net/profile/Hamidine-Illa/publication/369994288_MALI_MEDICAL_Article_original_Prevalence_de_l’infection_par_l’hepatite_virale_B_et_16_MALI_MEDICAL_2023_TOME_XXXVIII_N1_PREVALENCE_DE_L’INFECTION_PAR_L’HEPATITE_VIRALE_B_ET_FACTEURS_ASSOCIES_CHEZ_LES_/links/64382d8f20f25554da2bb30e/MALI-MEDICAL-Article-original-Prevalence-de-linfection-par-lhepatite-virale-B-et-16-MALI-MEDICAL-2023-TOME-XXXVIII-N1-PREVALENCE-DE-LINFECTION-PAR-LHEPATITE-VIRALE-B-ET-FACTEURS-ASSOCIES-CHEZ-LES-ENF.pdf
- Tounkara, A., Sarro, Y., Kristensen, S., Dao, S., Diallo, H., Diarra, B., et al . (2009) Seroprevalence of HIV/HBV Coinfection in Malian Blood Donors. Journal of the International Association of Providers of AIDS Care ( JIAPAC ), 8, 47-51. https://doi.org/10.1177/1545109708330118
- Dhumeaux, D. (2014) Conséquences cliniques et traitement de l’infection par le virus de l’hépatite B In: Prise en charge des personnes infectées par les virus de l’hépatite B ou de l’hépatite C. Rapport de recommandation 2014. ANRS. AFEF. EDP Sciences, Paris, 169-198. https://sante.gouv.fr/IMG/pdf/Rapport_Prise_en_charge_Hepatites_2014.pdf
- Katilé, D., Konaté, I., Goita, D., Kaboré, M., Dicko, M., Mallé, O., et al . (2018) Prévalence de l’Antigène Hbs et Profil Sérologique du Virus de l’Hépatite B en Consultation de Médecine Générale à l’Hôpital Régional de Kayes au Mali. Health Sciences and Disease , 19, 16-19.
- Dembelé, R. (2011) Profil épidémiologique et sérologique du virus de l’hépatite B dans un milieu urbain Bamako. Thèse médecine, Faculté de Médécine et d’Odontostomatologie, Bamako.