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Young patient with juvenile polyposis syndrome: A case report

¹ Gastroenterology Department, Fez University Hospital, Fez, Morocco
² Gastroenterology Department, Fez University Hospital, Fez, Morocco
³ Gastroenterology Department, Fez University Hospital, Fez, Morocco
⁴ Pathology Department, Fez University Hospital, Fez, Morocco
⁵ Pathology Department, Fez University Hospital, Fez, Morocco

Open Journal of Gastroenterology·Volume 02 (2012)·Pages 105–108·Published 30 August 2012·DOI10.4236/ojgas.2012.23022

Abstract

A case is reported here of juvenile polyposis in a 15- year-old girl. She was diagnosed upon the assessment of the dysenteric syndrome. Coloscopy and gastro- scopy had shown polyps of variable size whose histological study confirmed the hamartomatous character typical of the youthful non adenomatous polyps free of dysplasia. There was no localization in the small bowel. Coloprotectomy with ileoanal anastomosis was carried out in view of the importance of diarrhoea and the impacts on the general state of health.

KeywordsHamartomatous PolypPolyposisJuvenile PolypJuvenile Polyposis

Brosens, L.A.A., Langeveld, D., van Hattem, W.A., Giardiello, F.M. and Offerhaus, G.J.A. (2011) Juvenile polyposis syndrome. World Journal of Gastroenterology, 17, 4839-4844.
Watanabe, A., Nagashima, H., Motoi, M. and Ogawa, K. (1979) Familial juvenile polyposis of the stomach. Gastroenterology, 77, 148-151.
Brosens, L.A., van Hattem, W.A., Jansen, M., de Leng, W.W., Giardiello, F.M. and Offerhaus, G.J. (2007) Gastrointestinal polyposis syndromes. Current Molecular Medicine, 7, 29-46. doi:10.2174/156652407779940404
Gallione, C.J., Repetto, G.M., Legius, E., Rustgi, A.K., Schelley, S.L., Tejpar, S., Mitchell, G., Drouin, E., Westermann, C.J. and Marchuk, D.A.(2004) A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Lancet, 363, 852-859. doi:10.1016/S0140-6736(04)15732-2
Aaltonen, L.A., Jass, J.R. and Howe, J.R. (2000) Juvenile polyposis. In: Hamilton, S.R. and Aaltonen, L.A., Eds., Pathology and Genetics of Tumours of the Digestive System, IARC Press, Lyon, 130-132.
Jaeger, E., Leedham, S., Lewis, A., Segditsas, S., Becker, M., Cuadrado, P.R., Davis, H., Kaur, K., Heinimann, K., Howarth, K., East, J., Taylor, J., Thomas, H. and Tomlinson, I. (2012) Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. Nature Genetics, 44, 699-703. doi:10.1038/ng.2263
van Hattem, W.A., Langeveld, D., de Leng, W.W., Morsink, F.H., van Diest, P.J., Iacobuzio-Donahue, C.A., Giardiello, F.M., Offerhaus, G.J. and Brosens, L.A. (2011) Histological variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis. The American Journal of Surgical Pathology, 35, 530-536. doi:10.1097/PAS.0b013e318211cae1
Lam-Himlin, D., Park, J.Y., Cornish, T.C., Shi, C. and Montgomery, E. (2010) Morphologic characterization of syndromic gastric polyps. The American Journal of Surgical Pathology, 34, 1656-1662.
Calva-Cerqueira, D., Chinnathambi, S., Pechman, B., Bair, J., Larsen-Haidle, J. and Howe, J.R. (2009) The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis. Clinical Genetics, 75, 79-85. doi:10.1111/j.1399-0004.2008.01091.x
Delnatte, C., Sanlaville, D., Mougenot, J.F., Vermeesch, J.R., Houdayer, C., Blois, M.C., Genevieve, D., Goulet, O., Fryns, J.P., Jaubert, F., et al. (2006) Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. The American Journal of Human Genetics, 78, 1066-1074. doi:10.1086/504301

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Young patient with juvenile polyposis syndrome: A case report

Abstract

References (20)