Background and Aim: Patients with advanced liver disease have several risk factors to develop nutritional deficiencies. Accurate nutritional assessment is a real challenge because many of the traditionally measured parameters of nutritional status vary with severity of liver disease independently of nutritional status. The objective of this study was to assess the Egyptian patients with end stage liver disease and to compare different tools used to assess their nutritional status. Patients and Methods: 60 patients were nutritionally assessed by SGA, RFH-SGA anthropometry, handgrip dynamometry and biochemical tests. Clinical variables were cross analyzed with the nutritional assessment methods. Results: Malnutrition ranged from 7% by BMI and 100% by SGA. Agreement among all the methods was low compared with the SGA. Correlation between Malnutrition prevalence and the severity of liver disease was verified using Child-Pugh score more than MELD score. Conclusion: Malnutrition is highly prevalent among the Egyptian patients with end stage liver disease prior to liver transplantation. Although the diagnosis of nutritional status is not easy among this category of patients, it varied according to the method used. Nutritional support should be an important part of the preoperative care of liver transplantation patients.
KeywordsLiver TransplantationNutritionalstatusSGARFH-SGA and MELD
Alberino, F., Gatta, A. and Amodio, P. (2001) Nutrition and Survival in Patients with Liver Cirrhosis. Nutrition, 17, 445-450. http://dx.doi.org/10.1016/S0899-9007(01)00521-4
Roongpisunthinpong, C., Sobhonslidsuk, A., Nantiruj, K. and Songchitsomboon, S. (2001) Nutritional Assessment in Various Stages of Liver Cirrhosis. Nutrition, 17, 761-765. http://dx.doi.org/10.1016/S0899-9007(01)00626-8
Mattos, A.A., Coral, G.P., Menti, E., Valiatti, F. and Kramer, C. (2003) Infecção bacteriana no paciente cirrótico. Arq Gastroenterol, 40, 11-15. http://dx.doi.org/10.1590/S0004-28032003000100003
Pikul, J., Sharpe, M.D., Lowndes, R. and Ghent, C.N. (1994) Degree of Preoperative Malnutrition Is Predictive of Postoperative Morbidity and Mortality in Liver Transplant Recipients. Transplantation, 57, 469-472. http://dx.doi.org/10.1097/00007890-199402150-00030
Lautz, H.U., Selberg, O., Korber, J., Burger, M. and Muller, M.J. (1992) Protein-Calorie Malnutrition in Liver Cirrhosis. Clinical Investigation, 70, 478. http://dx.doi.org/10.1007/BF00210228
DiCecco, S.R., Wieners, E.J., Wiesner, R.H., Southorn, P.A., Plevak, D.J. and Krom, R.A. (1989) Assessment of Nutritional Status of Patients with End-Stage Liver Disease Undergoing Liver Transplantation. Mayo Clinical Process, 64, 95. http://dx.doi.org/10.1016/S0025-6196(12)65308-7
Stephenson, G.R., Moretti, E.W., El-Moalem, H., Clavien, P.A. and Tuttle-Newhall, J.E. (2001) Malnutrition in Liver Transplant Patients: Preoperative Subjective Global Assessment Is Predictive of Outcome after Liver Transplantation. Transplantation, 72, 666. http://dx.doi.org/10.1097/00007890-200108270-00018
Carvalho, L. and Parise, E.R. (2006) Evaluation of Nutritional Status of Nonhospitalized Patients with Liver Cirrhosis. Arq Gastroenterol, 43, 269. http://dx.doi.org/10.1590/S0004-28032006000400005
Selberg, O., Bottcher, J., Tusch, G., Pichlmayr, R., Henkel, E. and Muller, M.J. (1997) Identification of High- and Low-Risk Patients before Liver Transplantation: A Prospective Cohort Study of Nutritional and Metabolic Parameters in 150 Patients. Hepatology, 25, 652. http://dx.doi.org/10.1002/hep.510250327
Harrison, J., McKiernan, J. and Neuberger, J.M. (1997) A Prospective Study on the Effect of Recipient Nutritional Status on Outcome in Liver Transplantation. Transplant International, 10, 369. http://dx.doi.org/10.1111/j.1432-2277.1997.tb00931.x
DiCecco, S.R. and Francisco-Ziller, N. (2006) Nutrition in Alcoholic Liver Disease. Nutrition in Clinical Practice, 21, 245. http://dx.doi.org/10.1177/0115426506021003245
Detsky, A.S., McLaughlin, J.R., Baker, J.P., Johnston, N., Whittaker, S., Mendelson, R.A. and Jeejeebhoy, K.N. (1987) What Is Subjective Global Assessment of Nutritional Status? JPEN, 11, 8-13. http://dx.doi.org/10.1177/014860718701100108
Barbosa-Silva, M.C.G. and Barros, A.J.D. (2002) Avaliação nutricional subjetiva: Parte 2—Revisão de suas adaptações e utilizações nas diversas especialidades clínicas. Arq Gastroenterol, 39, 248-252.
Gottschall, C.A., álvaresda-Silva, M.R., Camargo, A.C., Burtett, R.M. and Silveira, T.R. (2004) Avaliação nutricional de pacientes com cirrose pelo vírusa da hepatite C: A aplicação da calorimetria indireta. Arq Gastroenterol, 41, 220-224. http://dx.doi.org/10.1590/S0004-28032004000400004
Morgan, M.Y., Madden, A.M., Soulsby, C.T. and Morris, R.W. (2006) Derivation and Validation of a New Global Method for Assessing Nutritional Status in Patients with Cirrhosis. Hepatology, 44, 823-835. http://dx.doi.org/10.1002/hep.21358
Teran, F. and McCullough, A. (2001) Nutrition in Liver Diseases. In: Gottshlich, M.M., Ed., American Society for Parenteral and Enteral Nutrition, Kendall Hant Publishing Company, St. Louis, 537-552.
Matos, C., Porayko, M.K., Francisco-Ziller, N. and DiCecco, S. (2002) Nutrition and Chronic Liver Disease. Journal of Clinical Gastroenterology, 35, 391-397. http://dx.doi.org/10.1097/00004836-200211000-00007
Loguercco, C., Sava, E., Murmo, R., et al. (1990) Malnutrition in Cirrhotic Patient Anthropometric Measurements as a Method of Assessing Nutritional Status. British Journal of Clinical Nutrition, 3, 98-181.
Teiusanu, A., Anderei, M., Arbanas, T., Nicolaie, U. and Diculescui, M. (2012) Nutritional Status in Cirrhotic Patients. Mædica (Buchar), 7, 284-289.
Barbosa-Silva, M.C. and Barros, A.J. (2005) Bioelectric Impedance and Individual Characteristics as Prognostic Factors for Post-Operative Complications. Clinical Nutrition, 24, 830-838. http://dx.doi.org/10.1016/j.clnu.2005.05.005
Pugh, R.N., Murray-Lyon, I.M., Dawson, J.L., Pietroni, M.C. and Williams, R. (1973) Transection of the Oesophagus for Bleeding Oesophageal Varices. British Journal of Surgery, 60, 646-649. http://dx.doi.org/10.1002/bjs.1800600817
Kamath, P.S., Wiesner, R.H., Malinchoc, M., Kremers, W., Therneau, T.M., Kosberg, C.L., D’Amico, G., Dickson, E.R. and Ray Kim, W. (2001) A Model to Predict Survival in Patients with End-Stage Liver Disease. Hepatology, 33, 464-470. http://dx.doi.org/10.1053/jhep.2001.22172
Mendenhall, C.L., Moritz, T.E., Roselle, G.A., et al. and VA Cooperative Study Group # 275 (1995) Protein Energy Malnutrition in Severe Alcoholic Hepatitis: Diagnosis and Response to Treatment. Journal of Parenteral and Enteral Nutrition, 19, 258-265. http://dx.doi.org/10.1177/0148607195019004258
Lee, R.D. and Nieman, D.C. (2003) Nutritional Assessment. McGraw Hill, New York.
Durnin, J.W.G.A. and Womersley, J. (1974) Body Fat Assessed from Total Body Density and Its Estimation from Skinfold Thickness: Measurements on 481 Men and Women Aged from 16 to 72 Years. British Journal of Nutrition, 32, 77-97.
Frisancho, A.R. (1984) New Standards of Weight and Body Composition by Frame Size and Height for Assessment of Nutritional Status of Adults and the Elderly. American Journal of Clinical Nutrition, 40, 808-819.
Kondrup, J. (2004) Basic Concepts in Nutrition. In: Sobotka, L., Ed., Basics in Clinical Nutrition, Gale′n, Prague, 1.
Sam, J. and Nguyen, G.C. (2009) Protein-Calorie Malnutrition as a Prognostic Indicator of Mortality among Patients Hospitalized with Cirrhosis and Portal Hypertension. Liver International, 29, 1396-1402. http://dx.doi.org/10.1111/j.1478-3231.2009.02077.x
Gunsar, F., Riamondo, M.L., Jones, S., Terreni, N., Wong, C., Patch, D., Sabin, C. and Burroughs, A.K. (2006) Nutritional Status and Prognosis in Cirrhotic Patients. Alimentary Pharmacology & Therapeutics, 24, 563-572. http://dx.doi.org/10.1111/j.1365-2036.2006.03003.x
Zaina, F.E., Parolin, M.B., Lopes, R.W. and Coelho, J.C. (2004) Prevalence of Malnutrition in Liver Transplant Candidates. Transplantation Proceedings, 36, 923-925. http://dx.doi.org/10.1016/j.transproceed.2004.04.068
Muller, M.J., Bottcher, J., Selberg, O., Weselmann, S., Böker, K.H., Schwarze, M., von zur Mühlen, A. and Manns, M.P. (1999) Hypermetabolism in Clinically Stable Patients with Liver Cirrhosis. American Journal of Clinical Nutrition, 69, 1194-1201.
Alvaresda-Silva, M.R. and Reverbel da Silveira, T. (2005) Comparison between Handgrip Strength, Subjective Global Assessment, and Prognostic Nutritional Index in Assessing Malnutrition and Predicting Clinical Outcome in Cirrhotic Outpatients. Nutrition, 21, 113-117. http://dx.doi.org/10.1016/j.nut.2004.02.002
Plauth, M., Cabre, E., Riggio, O., et al. (2006) ESPEN Guidelines on Enteral Nutrition: Liver Disease. Clinical Nutrition, 25, 285-294. http://dx.doi.org/10.1016/j.clnu.2006.01.018
Vulcano, D.S.B., de Barros Leite Carvalhaes, M.A. and Bakonyi Neto, A. (2013) Evaluation of Nutritional Indicators and Body Composition in Patients with Advanced Liver Disease Enrolled for Liver Transplantation. Acta Cirúrgica Brasileira, 28, 733-739.
Campillo, B., Richardet, J.P. and Bories, P.N. (2006) Validation of Body Mass Index for the Diagnosis of Malnutrition in Patients with Liver Cirrhosis. Gastroentérologie Clinique et Biologique, 30, 1137-1143. http://dx.doi.org/10.1016/S0399-8320(06)73491-1
Antaki, F., French, M.M., Moonka, D.K. and Gordon, S.C. (2008) Bioelectrical Impedance Analysis for the Evaluation of Hepatic Fibrosis in Patients with Chronic Hepatitis C Infection. Digestive Diseases and Sciences, 53, 1957-1960. http://dx.doi.org/10.1007/s10620-007-0071-3
Merli, M., Riggio, O. and Dally, L. (1996) Does Malnutrition Affect Survival in Cirrhosis? PINC (Policentrica Italiana Nutrizione Cirrosi). Hepatology, 23, 1041-1046. http://dx.doi.org/10.1002/hep.510230516
Caly, W.R., Strauss, E., Carrilho, F.J. and Laudanna, A.A. (2003) Different Degrees of Malnutrition and Immunological Alterations According to the Aetiology of Cirrhosis: A Prospective and Sequential Study. Nutrition Journal, 7, 2.
Piquet, M.A., Ollivier, I., Gloro, R., Castel, H., Tiengou, L.E. and Dao T. (2006) Nutritional Indices in Cirrhotic Patients. Nutrition, 22, 8-9. http://dx.doi.org/10.1016/j.nut.2005.06.004
Stickel, F., Inderbitzin, D. and Condinas, D. (2008) Role of Nutrition in Liver Transplantation for End-Stage Chronic Liver Disease. Nutrition and Clinical Care, 66, 47-54.
Tsiaousi, E.T., Hatzitolios, A.I., Trygonis, S.K. and Savopoulos, C.G. (2008) Malnutrition in End Stage Liver Disease: Recommendations and Nutritional Support. Journal of Gastroenterology and Hepatology, 23, 527-533. http://dx.doi.org/10.1111/j.1440-1746.2008.05369.x