The Diagnostic Challenges, Possible Etiologies and Lack of Researches of Hepatocellular Carcinoma in Somalia
- 1 Dufle Specialist Hospital, Mogadishu, Somalia
- 2 Abrar Research and Training Centre, Abrar University, Mogadishu, Somalia
- 3 Peoples' Friendship University of Russia (RUDN University), Moscow, Russia
Abstract
Globally, hepatocellular carcinoma is the second amongst all causes of cancer deaths and it is one of the common malignancies in both developing and developed countries. The causes are variety all of the world ranging from geography, life style and advanced medical care that is available in th ose countries either developing such as Somalia or developed countries. Somali contributes to global burden of hepatitis B which is a known risk factor for HCC and has categorized to the world a part of high prevalence of hepatitis B which is greater than 10%, while there is no more available data of hepatitis C in Somalia that contributes the world. Diagnos e s of hepatocellular carcinoma are now forward in many countries of developed world, but reality are different from developing countries such as Somalia which is now out for civil war and has a lack of medical experts in all fields of medicine such as physician, surgeons, pathologists, radiologists and the experts of the laboratory field, even if we have these medical personal who are few or they are elder than above 60 years old plus medical equipment (such as i maging and laboratory equipment). All these challenges, the author of this manuscript ha s faith in the diagnosis of hepatocellular carcinoma that can be rationally made to consider the clinical presentation of this disorder and to maximiz e use of offered diagnostic tools and to refer the few medical experts in the country.
- International Agency for Research on Cancer (2014) World Cancer Report 2014. IARC, Lyon.
- Perz, J.F., Armstrong, G.L., Farrington, L.A., et al. (2006) The Contributions of Hepatitis B Virus and Hepatitis C Virus Infections to Cirrhosis and Primary Liver Cancer Worldwide. Journal of Hepatology, 45, 529-538. https://doi.org/10.1016/j.jhep.2006.05.013
- Mittal, S. and El-Serag, H.B. (2013) Epidemiology of Hepatocellular Carcinoma: Consider the Population. Journal of Clinical Gastroenterology, 47, S2-S6.
- Khalif, B., Cadigia, A., Heléne, N., Lars, M., Greger, L. and Lars, N. (1993) Important Role of Hepatitis C Virus Infection as a Cause of Chronic Liver Disease in Somalia. Scandinavian Journal of Infectious Diseases, 25, 559-564. https://doi.org/10.3109/00365549309008543
- Shire, A.M., Sandhu, D.S., Kaiya, J.K., Oseini, A.M., Yang, J.D., et al. (2012) Viral Hepatitis among Somali Immigrants in Minnesota: Association of Hepatitis C with Hepatocellular Carcinoma. Mayo Clinic Proceedings, 87, 17-24. https://doi.org/10.1016/j.mayocp.2011.08.001
- Kadle, M., Hassan, A.M., Yasin, A.M., Sheikh, A.H., Omar, M.Sh. and Sayid, A.M. (2012) Frequency of Hepatocellular Carcinoma and Its Associated of Hepatitis B and C in Patients Attending Mogadishu Hospitals. https://www.researchgate.net/publication/309564485_Frequency_of_Hepatocellular_Carcinoma_ and_its_associated_Hepatitis_B_and_C_in_Patients_attending_Mogadishu_hospitals
- National Comprehensive Cancer Network (2013) NCCN Clinical Practice Guidelines in Oncology: Hepatobiliary Cancers. National Comprehensive Cancer Network, Fort Washington.
- European Association for the Study of the Liver and European Organisation for Research and Treatment of Cancer (2012) EASLEORTC Clinical Practice Guidelines: Management of Hepatocellular Carcinoma. Journal of Hepatology, 56, 908-943. https://doi.org/10.1016/j.jhep.2011.12.001
- Villanueva, A., Minguez, B., Forner, A., Reig, M. and Llovet, J.M. (2010) Hepatocellular Carcinoma: Novel Molecular Approaches for Diagnosis, Prognosis, and Therapy. Annual Review of Medicine, 61, 317-328. https://doi.org/10.1146/annurev.med.080608.100623
- Hoshida, Y., Nijman, S.M.B., Kobayashi, M., et al. (2009) Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma. Cancer Research, 69, 7385-7392. https://doi.org/10.1158/0008-5472.CAN-09-1089
- Zhang, B. and Yang, B. (1999) Combined Alpha Fetoprotein Testing and Ultrasonography as a Screening Test for Primary Liver Cancer. Journal of Medical Screening, 6, 108-110. https://doi.org/10.1136/jms.6.2.108