Research ArticleOpen AccessGoogle Scholar indexed
The Synergistic Effects Study of C-myc and C-erbB-2 in the Carcinogenesis of Gastric Carcinoma
Departments of 1Clinical Laboratory, Affiliated Hospital of Taishan Medical University, Tai’an, China
General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
Hematology, Affiliated Hospital of Taishan Medical University, Tai’an, China
Pathology, Affiliated Hospital of Taishan Medical University, Tai’an, China
Departments of 1Clinical Laboratory, Affiliated Hospital of Taishan Medical University, Tai’an, China
Medical Laboratory Class, Grade 2016, Medical College, Qingdao University, Qingdao, China
General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 1 Departments of 1Clinical Laboratory, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 2 General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 3 Hematology, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 4 Pathology, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 5 Departments of 1Clinical Laboratory, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 6 Medical Laboratory Class, Grade 2016, Medical College, Qingdao University, Qingdao, China
- 7 General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
- 8 General Surgery, Affiliated Hospital of Taishan Medical University, Tai’an, China
Open Journal of Gastroenterology·Volume 07 (2017)·Pages 308–315·Published 28 December 2017·DOI10.4236/ojgas.2017.712032
Copy link · social · email
Abstract
Objective: To study the significance of c-myc and c-erbB-2 oncogene expression in gastric cancer. Methods: 81 gastric cancer specimens were detected for c-myc and c-erbB-2 oncogene amplification using non-radioactive in situ hybridization method. Results: The amplification rates for c-myc and c-erbB-2 were 67.9% and 50.6% respectively, and there were significant correlation in the amplification of these two genes (χ2 = 7.26, P < 0.01). Conclusions: The amplification of c-myc and c-erbB-2 may play an important role in gastric cancer development, and these two genes may have synergistic effect.
Keywordsc-mycc-erbB-2Synergistic Effects
- Amati, B., Alevizopoulos, K. and Vlach, J. (1998) Myc and the Cell Cycle. Frontiers in Bioscience, 3, D250-268. https://doi.org/10.2741/A239
- Knudsen, E.S., McClendon, A.K., Franco, J., Ertel, A., Fortina, P. and Witkiewicz, A.K. (2015) RB Loss Contributes to Aggressive Tumor Phenotypes in MYC-Driven Triple Negative Breast Cancer. Cell Cycle, 14, 109-122. https://doi.org/10.4161/15384101.2014.967118
- Tang, B., Xie, R., Qin, Y., Xiao, Y.F., Yong, X., Zheng, L., Dong, H. and Yang, S.M. (2016) Human Telomerase Reverse Transcriptase (hTERT) Promotes Gastric Cancer Invasion through Cooperating with c-Myc to Upregulate Heparanase Expression. Oncotarget, 7, 11364-11379. https://doi.org/10.18632/oncotarget.6575
- Ishii, H.H., Gobé, G.C., Pan, W., Yoneyama, J. and Ebihara, Y. (2002) Apoptosis and Cell Proliferation in the Development of Gastric Carcinomas: Associations with c-myc and p53 Protein Expression. Journal of Gastroenterology and Hepatology, 17, 966-972. https://doi.org/10.1046/j.1440-1746.2002.02805.x
- Br?gelmann, J., B?hm, S., Guthrie, M.R., Mollaoglu, G., Oliver, T.G. and Sos, M.L. (2017) Family Matters: How MYC Family Oncogenes Impact Small Cell Lung Cancer. Cell Cycle, 16, 1489-1498. https://doi.org/10.1080/15384101.2017.1339849
- Xie, D., Sham, J.S., Zeng, W.F., Lin, H.L., Che, L.H., Wu, H.X., Wen, J.M., Fang, Y., Hu, L. and Guan, X.Y. (2003) Heterogeneous Expression and Association of Beta-Catenin, p16 and c-myc in Multistage Colorectal Tumorigenesis and Progression Detected By Tissue Microarray. International Journal of Cancer, 107, 896-902. https://doi.org/10.1002/ijc.11514
- Li, F.L., Deng, H., Wang, H.W., Xu, R., Chen, J., Wang, Y.F., Li, X., Fan, B. and Li, B. (2011) Effects of External Application of Chinese Mcdicine on Diabetic Ulcers and the Expressions of β-Catenin,c-myc and K6. Chinese Journal of Integrative Medicine, 17, 261-266. https://doi.org/10.1007/s11655-011-0703-5
- Albihn, A., Johnsen, J.I. and Henriksson, M.A. (2010) MYC in Oncogenesis and as a Target for Cancer Therapies. Advances in Cancer Research, 107, 163-224. https://doi.org/10.1016/S0065-230X(10)07006-5
- Skvortsova, I., Skvortsov, S., Raju, U., Stasyk, T., Riesterer, O., Schottdorf, E.M., Popper, B.A., Schiestl, B., Eichberger, P., Debbage, P., Neher, A., Bonn, G.K., Huber, L.A., Milas, L. and Lukas, P. (2010) Epithelial-to-Mesenchymal Transition and c-myc Edpression Are the Detemninants of Cetuximab-Induced Enhancement of Squamous Cell Carcinoma Radioresponse. Radiotherapy and Oncology, 96, 108-115. https://doi.org/10.1016/j.radonc.2010.04.017