The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies — Oak Academic Publishing
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The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies
Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
,
Department of Psychiatry, Harvard School of Medicine, Cambridge, MA, USA
,
Department of Management Science and Statistics, University of Texas, San Antonio, TX, USA
,
Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
,
Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
,
Future Biologics, Lawrenceville, GA, USA
,
Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
,
Department of Microbiology, Immunology, & Tropic Diseases, School of Medicine, Georgetown University, Washington DC, USA
,
Department of Pharmaceutical Sciences, College of Pharmacy, Texas Southern University, Houston, TX, USA
,
The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
,
Department of Psychiatry, School of Medicine, Case Western University, Cleveland, OH, USA
,
Brain and Behavior Laboratory, Curry College, Milton, MA, USA
,
The Neurogenesis Project, Jacksonville, FL, USA
,
Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA
,
The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
,
Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel
,
Division of Neuromodulation Research, Karma Doctors & Karma TMS, Palm Springs, CA, USA
,
Division of Personalized Interventions, Peak Logic, Del Mar, CA, USA
,
Division of Personalized Medicine, Cross-Cultural Research & Educational Institute, San Clemente, CA, USA
,
Awareness Integration Institute, San Clemente, CA, USA
,
Division Pediatric Neurology, School of Medicine, University of Missouri, Columbia, MO, USA
,
Department of Psychiatry, School of Medicine, Washington University, St. Louis, MO, USA
,
Division of Personalized Pain Therapy, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ, USA
,
Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
,
The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
,
Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
,
Department of Psychiatry, Boonshoft School of Medicine, Wright State University and Dayton VA Medical Centre, Dayton, OH, USA
,
Division of Nutrigenomics, Victory Nutrition International, Lederoch, PA, USA
,
Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary
,
Department of Psychiatry, School of Medicine, University of Vermont, Burlington, VT, USA
,
Department of Psychiatry, UC Riverside School of Medicine, University California, Riverside, CA, USA
,
Department of Human Development, California State University at Long Beach, Long Beach, CA, USA
,
Department of Health Science, California State University at Long Beach, Long Beach, CA, USA
1 Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
2 Department of Psychiatry, Harvard School of Medicine, Cambridge, MA, USA
3 Department of Management Science and Statistics, University of Texas, San Antonio, TX, USA
4 Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
5 Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
6 Future Biologics, Lawrenceville, GA, USA
7 Division of Addiction Research & Education, Center for Sports and Mental Health, Western University of Health Sciences, Pomona, CA, USA
8 Department of Microbiology, Immunology, & Tropic Diseases, School of Medicine, Georgetown University, Washington DC, USA
9 Department of Pharmaceutical Sciences, College of Pharmacy, Texas Southern University, Houston, TX, USA
10 The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
11 Department of Psychiatry, School of Medicine, Case Western University, Cleveland, OH, USA
12 Brain and Behavior Laboratory, Curry College, Milton, MA, USA
13 The Neurogenesis Project, Jacksonville, FL, USA
14 Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA
15 The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
16 Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel
17 Division of Neuromodulation Research, Karma Doctors & Karma TMS, Palm Springs, CA, USA
18 Division of Personalized Interventions, Peak Logic, Del Mar, CA, USA
19 Division of Personalized Medicine, Cross-Cultural Research & Educational Institute, San Clemente, CA, USA
Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN ® ) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN ® ), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as glutathione to address offensive enhanced cytokines, in patients with suspected PANDAS/CANS.
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20 Awareness Integration Institute, San Clemente, CA, USA
21 Division Pediatric Neurology, School of Medicine, University of Missouri, Columbia, MO, USA
22 Department of Psychiatry, School of Medicine, Washington University, St. Louis, MO, USA
23 Division of Personalized Pain Therapy, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ, USA
24 Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
25 The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA
26 Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
27 Department of Psychiatry, Boonshoft School of Medicine, Wright State University and Dayton VA Medical Centre, Dayton, OH, USA
28 Division of Nutrigenomics, Victory Nutrition International, Lederoch, PA, USA
29 Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary
30 Department of Psychiatry, School of Medicine, University of Vermont, Burlington, VT, USA
31 Department of Psychiatry, UC Riverside School of Medicine, University California, Riverside, CA, USA
32 Department of Human Development, California State University at Long Beach, Long Beach, CA, USA
33 Department of Health Science, California State University at Long Beach, Long Beach, CA, USA
Infections
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