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Seasonal modulation of the C-type lectin MGL on human DCs
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
- 1 Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
- 2 Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
- 3 Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
- 4 Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
- 5 Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;
Open Journal of Immunology·Volume 03 (2013)·Pages 218–220·Published 11 December 2013·DOI10.4236/oji.2013.34027
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Abstract
The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (M f s) , able to bind GalNAc (Tn) carrying structures. This receptor also recognized Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible application in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL + donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of glucocorticoids, in fact MGL is up-regulated in presence of dexamethasone in vitro . The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.
KeywordsMGLDendritic CellsC-Type Lectin
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