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Serum Concentrations of Angiotensin, C-Reactive Protein, Interleukin-8, and Tumor Necrosis Factor-α in Train Driver Population
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Department of Microbiology and Immunology, School of Basic Medical Science, Kunming Medical University, Kunming, China
Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
Yunnan Province Base for International Scientific and Technological Cooperation in Tropical Diseases, Kunming, China
Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Department of Microbiology and Immunology, School of Basic Medical Science, Kunming Medical University, Kunming, China
Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
Yunnan Province Base for International Scientific and Technological Cooperation in Tropical Diseases, Kunming, China
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- 1 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 2 Department of Microbiology and Immunology, School of Basic Medical Science, Kunming Medical University, Kunming, China
- 3 Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
- 4 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 5 Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
- 6 The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- 7 Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
- 8 Yunnan Province Base for International Scientific and Technological Cooperation in Tropical Diseases, Kunming, China
- 9 Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
- 10 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 11 Department of Microbiology and Immunology, School of Basic Medical Science, Kunming Medical University, Kunming, China
- 12 Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
- 13 The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- 14 Yunnan Province Base for International Scientific and Technological Cooperation in Tropical Diseases, Kunming, China
- 15 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 16 Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
- 17 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 18 Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Kunming Medical University, Kunming, China
- 19 Yunnan Key Laboratory for Tropical Infectious Diseases, Kunming, China
- 20 Yunnan Collaborative Innovation Center for Public Health and Disease Control, Kunming, China
- 21 The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
Open Journal of Immunology·Volume 06 (2016)·Pages 7–13·Published 2 March 2016·DOI10.4236/oji.2016.61002
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Abstract
Train drivers are engaged in high-stress job. It may induce sleep, fatigue, and alertness loss at work, and endanger public safety. It’s unclear that cytokines of train driver would be influenced by their job. The research considers the hypothesis that stressful professions, such as train driver, influence the body’s immune system through the long-time and high-pressure working, and change production of neuro-immune factors. Using enzyme linked immunosorbent assay (ELISA), several neuro-immune factors were assayed among train drivers (N = 82) and health blood donors (N = 80) enrolled in the Yunnan Collaborative Innovation Center for Public Health and Disease Control. The concentrations of angiotensin, C-reactive protein (CRP), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) were determined. Kruskal-Wallis test and Dunn’s multiple comparisons test were performed for overall comparison between groups and for pairwise comparison, respectively. Statistical significance level was set at P < 0.05. The profession of train driving was not associated with significant increases or decreases in the systemic levels of inflammatory (CRP, IL-8, and TNF-α), but it was associated with the high expression of angiotensin in vivo. These findings suggest that the job of train driving may not be associated with significant alterations in systemic immune condition, but arouse the level of angiotensin.
KeywordsTrain DriverOccupational StressAngiotensinC-Reactive ProteinInterleukin-8Tumor Necrosis Factor-Alpha
- Loukzadeh, Z., Zare, Z., Mehrparvar, A.H., Mirmohammadi, S.J. and Mostaghaci, M. (2013) Fitness-for-Work Assessment of Train Drivers of Yazd Railway, Central Iran. International Journal of Occupational and Environmental Medicine, 4, 157-163.
- Harma, M., Sallinen, M., Ranta, R., Mutanen, P. and Müller, K. (2002) The Effect of an Irregular Shift System on Sleepiness at Work in Train Drivers and Railway Traffic Controllers. Journal of Sleep Research, 11, 141-151. http://dx.doi.org/10.1046/j.1365-2869.2002.00294.x
- Sallinen, M., Härmä, M., Mutanen, P., Ranta, R., Virkkala, J. and Müller, K. (2003) Sleep-Wake Rhythm in an Irregular Shift System. Journal of Sleep Research, 12, 103-112. http://dx.doi.org/10.1046/j.1365-2869.2003.00346.x
- Kim, S.E., Kim, H.R., Park, J.I., Lee, H.W., Lee, J., Byun, J. and Yim, H.W. (2014) The Association between Psychiatric Disorders and Work-Related Problems among Subway Drivers in Korea. Annals of Occupational and Environmental Medicine, 26, 39. http://dx.doi.org/10.1186/s40557-014-0039-7
- Jovanovic, J. and Jovanovic, M. (2004) Occupational Stress and Arterial Hypertension. Medicinski Pregled, 57, 153-158. http://dx.doi.org/10.2298/MPNS0404153J
- Buyken, A.E., Goletzke, J., Joslowski, G., Felbick, A., Cheng, G., Herder, C. and Brand-Miller, J.C. (2014) Association between Carbohydrate Quality and Inflammatory Markers: Systematic Review of Observational and Interventional Studies. American Journal of Clinical Nutrition, 99, 813-833. http://dx.doi.org/10.3945/ajcn.113.074252
- Martynowicz, H., Janus, A., Nowacki, D. and Mazur, G. (2014) The Role of Chemokines in Hypertension. Advances in Clinical and Experimental Medicine, 23, 319-325. http://dx.doi.org/10.17219/acem/37123
- Hughes, A., McMunn, A., Bartley, M. and Kumari, M. (2015) Elevated Inflammatory Biomarkers during Unemployment: Modification by Age and Country in the UK. Journal of Epidemiology and Community Health, 69, 673-679. http://dx.doi.org/10.1136/jech-2014-204404
- Yoon, H.S., Lee, K.M. and Kang, D. (2014) Intercorrelation between Immunological Biomarkers and Job Stress Indicators among Female Nurses: A 9-Month Longitudinal Study. Frontiers in Public Health, 2, 157. http://dx.doi.org/10.3389/fpubh.2014.00157
- Opie, L.H. (2014) Cognitive Decline: Mechanisms and Proposed Role of the Renin-Angiotensin-Aldosterone System. Cardiovascular Journal of Africa, 25, 149-150.
- Ramanathan, G., Elumalai, R., Periyasamy, S. and Lakkakula, B. (2014) Role of Renin-Angiotensin-Aldosterone System Gene Polymorphisms and Hypertension-Induced End-Stage Renal Disease in Autosomal Dominant Polycystic Kidney Disease. Iranian Journal of Kidney Diseases, 8, 265-277.