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Immunological Status to Hepatitis B Virus of Pregnant Women in Dakar, Senegal

¹ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
² Laboratory of Medical Biology, General Hospital of Grand-Yoff, Dakar, Senegal
³ Laboratory of Medical Biology, General Hospital of Grand-Yoff, Dakar, Senegal
⁴ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
⁵ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
⁶ Laboratory of Medical Biology, General Hospital of Grand-Yoff, Dakar, Senegal
⁷ Laboratory of Medical Biology, General Hospital of Grand-Yoff, Dakar, Senegal
⁸ Department of Biological and Pharmaceutical Applied Sciences, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
⁹ Department of Biological and Pharmaceutical Applied Sciences, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
¹⁰ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
¹¹ Laboratory of Medical Biology, General Hospital of Grand-Yoff, Dakar, Senegal
¹² Department of Biological and Pharmaceutical Applied Sciences, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
¹³ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal
¹⁴ Service of Immunology, Faculty of Medicine, Pharmacy and Odontology (FMPO), Cheikh Anta Diop University of Dakar (UCAD), Dakar, Senegal

Open Journal of Immunology·Volume 07 (2017)·Pages 37–44·Published 30 June 2017·DOI10.4236/oji.2017.72003

Abstract

Objective: Evaluate the immunological status to hepatitis B virus of Senegalese pregnant women by screening HBs antigen. Material and methods: The selection criteria of women were presence at the laboratory for biological exams of pregnancy follow-up. All volunteers for the study were screened for HBs antigen (HBs Ag). Investigation of chronic hepatitis B markers (HBe Ag, anti-HBe, viral quantification) was performed in HBs Ag positive participants. The concentration of anti-HBs antibodies was assessed in HBs Ag negative women. Results: One hundred and fifteen (115) pregnant women were included in the study from July to October 2014. The mean age was 29 ± 6 years, ranging from 16 to 47. The seroprevalence of HBs Ag was 12% and the majority of women (90%) were not vaccinated. Any of the 14 HBs Ag-positive subjects did not express serum HBe Ag, (marker of active viral replication) and all were positive for anti-HBe antibodies. Their viral load (HBV DNA) was undetectable and serum transaminases were normal. The anti-HBs antibodies titrated in HBs-Ag negative women serum revealed that only 46 had protective levels against HBV whilst 55 of them were unprotected.

KeywordsHBs AgPregnancySenegal

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Immunological Status to Hepatitis B Virus of Pregnant Women in Dakar, Senegal

Abstract

References (17)