Blood Count Abnormalities Associated with Death in Patients Infected with SARS-COV-2 at the Ziguinchor EpidemicTreatment Center (ETC) — Oak Academic Publishing
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Blood Count Abnormalities Associated with Death in Patients Infected with SARS-COV-2 at the Ziguinchor EpidemicTreatment Center (ETC)
Medical Analysis Laboratory, The Ziguinchor Peace Hospital, Ziguinchor, Senegal
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Infectious Diseases Department, The Ziguinchor Peace Hospital/Ziguinchor Epidemic Treatment Center, Ziguinchor, Senegal
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Health Sciences Training and Research Unit, The Assane Seck University of Ziguinchor, Ziguinchor, Senegal
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Medical Analysis Laboratory, The Ziguinchor Regional Hospital, Ziguinchor, Senegal
,
Infectious Diseases Department, The Ziguinchor Peace Hospital/Ziguinchor Epidemic Treatment Center, Ziguinchor, Senegal
,
Health Sciences Training and Research Unit, The Assane Seck University of Ziguinchor, Ziguinchor, Senegal
1 Medical Analysis Laboratory, The Ziguinchor Peace Hospital, Ziguinchor, Senegal
2 Infectious Diseases Department, The Ziguinchor Peace Hospital/Ziguinchor Epidemic Treatment Center, Ziguinchor, Senegal
3 Health Sciences Training and Research Unit, The Assane Seck University of Ziguinchor, Ziguinchor, Senegal
4 Medical Analysis Laboratory, The Ziguinchor Regional Hospital, Ziguinchor, Senegal
5 Infectious Diseases Department, The Ziguinchor Peace Hospital/Ziguinchor Epidemic Treatment Center, Ziguinchor, Senegal
6 Health Sciences Training and Research Unit, The Assane Seck University of Ziguinchor, Ziguinchor, Senegal
Introduction: SARS-COV-2 infection is a real public health challenge for the World Health Organization and for our country. It is responsible for numerous hematological abnormalities in infected patients. Objectives: To describe the haemogram abnormalities in patients infected with SARS-COV-2 and to determine which ones are associated with death. Material and Method: We conducted a retrospective, descriptive, analytical, cross-sectional study from March 2020 to September 2021. The study included all patients hospitalized with RT-PCR-confirmed COVID-19 who performed a blood count. We evaluated the blood count profile, the pathologies found and the associated blood count abnormalities. Results: A total of 263 patients were included. The mean age of the patients was 63.77 years (range 12 - 90 years). The male sex represented 54.75% (n = 144) while the female sex was 45.25% (n = 119) (sex ratio = 1.21). The most common pathologies were: diabetes: 30.03% (n = 79), high blood pressure: 41.04% (n = 108), and Chronic kidney disease: 7.98 (n = 21). The abnormalities of the haemogram found were essential: anaemia 28.13% (n = 121), hyperleukocytosis with neutrophilic predominance: 29.3% (126), lymphopenia: 34.41% (n = 148), thrombocytopenia: 8.16% (n = 35). The search for hematological factors associated with death in patients showed a significant difference between hyperleukocytosis (p = 0.000) and lymphopenia (p = 0.0001). Conclusion: SARS-COV-2 disease was a mortality factor when associated with lymphopenia and hyperleukocytosis in our series.
Frimousse, S. and Peretti, J.M. (2020) Organizational Changes Induced by the Covid-19 Crisis. Questions de Management, 3, 105-149. https://doi.org/10.3917/qdm.203.0105
Defraigne, J.C. (2020) The Geoeconomic Impact of Covid-19 on the Globalized Economy. Outre-Terre, 57, 23-46. https://doi.org/10.3917/oute2.057.0023
World Health Organization (WHO) (2022) Public Health Surveillance in the Context of COVID-19: Interim Guidance. 22 July 2022. https://www.who.int/publications/i/item/WHO-2019-nCoV-SurveillanceGuidance-2022.2
Kaeuffer, C., Le Hyaric, C., Fabacher, T., Mootien, J., Ruch, Y., Zhu, Y.J., et al. (2020) Clinical Features and Risk Factors Associated with Severe Forms of COVID-19: A Prospective Multicenter Analysis of 1045 Cases. Médecine et Maladies Infectieuses, 50, S27. https://doi.org/10.1016/j.medmal.2020.06.440
Plaçais, L. and Richier, Q. (2020) COVID-19: Clinical, Biological and Radiological Characteristics in Adults, Pregnant Women and Children. An Update in the Midst of the Pandemic. La Revue de Médecine Interne, 41, 308-318. https://doi.org/10.1016/j.revmed.2020.04.004
Osman, M., Safer, M., Hechaichi, A., Letaief, H., Dhaouadi, S., Harizi, C., et al. (2019) Predictive Factors of Covid-19 Mortality: Review of the Literature. https://www.onmne.tn/wp-content/uploads/2020/10/Facteurs-de-mortalite-COVID-19_HBS_8_10_2020.pdf
Violetis, O.A., Chasouraki, A.M., Giannou, A.M. and Baraboutis, I.G. (2020) COVID-19 Infection and Haematological Involvement: A Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings. SN Comprehensive Clinical Medicine, 2, 1089-1093. https://doi.org/10.1007/s42399-020-00380-3
Toba, N., Gupta, S., Ali, A.Y., ElSaban, M., Khamis, A.H., Ho, S.B., et al. (2021) COVID-19 under 19: A Meta-Analysis. Pediatric Pulmonology, 56, 1332-1341. https://doi.org/10.1002/ppul.25312
Agbuduwe, C. and Basu, S. (2020) Haematological Manifestations of COVID-19: From Cytopenia to Coagulopathy. European Journal of Haematology, 105, 540-546. https://doi.org/10.1111/ejh.13491
Rahman, M.A., et al. (2022) Hematological Abnormalities and Comorbidities Are Associated with COVID-19 Severity among Hospitalized Patients: Experience from Bangladesh. PLOS ONE, 16, e0255379. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255379
Chen, X., Yan, L., Fei, Y. and Zhang, C. (2020) Laboratory Abnormalities and Risk Factors Associated with In-Hospital Death in Patients with Severe COVID-19. Journal of Clinical Laboratory Analysis, 34, e23467. https://doi.org/10.1002/jcla.23467
Daoui, M.A. (2021) Epidemiological, Clinical and Biological Profile of COVID-19 Patients Hospitalized at the Hassan II CHR in Agadir. http://wd.fmpm.uca.ma/biblio/theses/annee-htm/FT/2021/these138-21.pdf
Taj, S., Fatima, S.A., Imran, S., Lone, A. and Ahmed, Q. (2021) Role of Hematological Parameters in the Stratification of COVID-19 Disease Severity. Annals of Medicine and Surgery, 62, 68-72. https://doi.org/10.1016/j.amsu.2020.12.035
Diallo, K., Thioubou, M.A., Wembulua, B.S., Kane, Y. and Coly, M.N. (2021) COVID-19: Experience of the Epidemic Treatment Center of Ziguinchor, Southern Region of Senegal. Journal of Infectious Diseases and Epidemiology, 7, Article 216.
Diop, M., Ba, P.S., Moustapha, L., et al. (2021) Factors Associated with Severe COVID-19 in an Epidemic Treatment Center at Dakar. Journal of Infectious Diseases and Epidemiology, 7, 2474-3658. https://doi.org/10.23937/2474-3658/1510203
Faye, F.A., Berthe, A., Lawson, T.A.D., et al. (2021) Mise en place d’un centre de traitement des épidémies (CTE) pour Covid-19 dans un service de Médecine Interne; Les leçonsapprises. Revue Africaine de Médecine Interne, 8, 32-36.
Angelo, A.C., Clodel, Y., Léopold, C., Serge, A., Ibrahim, M.C., Julien, A., et al. (2023) Epidemiological, Clinical, Therapeutic Features and Predictors of Death among COVID-19 Patients Hospitalized in Parakou: A Cross-Sectional Study in Northern Benin. BMC Infectious Diseases, 23, Article No. 484. https://doi.org/10.1186/s12879-023-08445-z
Yang, X., et al. (2020) Clinical Course and Outcomes of Critically Ill Patients with SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. The Lancet Respiratory Medicine, 8, 475-481. https://doi.org/10.1016/S2213-2600(20)30079-5
Zhou, F., et al. (2020) Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet, 395, 1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Wu, C.M., Chen, X.Y., Cai, Y.P., et al. (2020) Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Internal Medicine, 180, 934-943. https://doi.org/10.1001/jamainternmed.2020.0994
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., et al. (2020) Clinical Characteristics of Corona-Virus Disease 2019 in China. The New England Journal of Medicine, 382, 1708-1720. https://doi.org/10.1056/NEJMoa2002032
World Health Organization (2021) WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/
Zhou, F., Yu, T., Du, R.H., Fan, G.H., Liu, Y., Liu, Z.B., et al. (2020) Clinical Course an Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: A Retrospective Cohort Study. The Lancet, 3959, 1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Goyal, P., Choi, J.J., Pinheiro, L.C., et al. (2020) Clinical Characteristics of Covid-19 in New York City. The New England Journal of Medicine, 382, 2372-2374. https://doi.org/10.1056/NEJMc2010419
Faye, A., Ndao, A., Diagne, N., et al. (2022) The COVID-19 Pandemic in Senegal: Experience of an Internal Medicine Department as an Epidemic Treatment Center. Open Journal of Internal Medicine, 12, 13-21. https://doi.org/10.4236/ojim.2022.121002
Sun, S., Cai, X., Wang, H., He, G., Lin, Y., Lu, B., et al. (2020) Abnormalities of Peripheral Blood System in Patients with COVID-19 in Wenzhou, China. Clinica Chimica Acta, 507, 174-180. https://doi.org/10.1016/j.cca.2020.04.024
Rahman, A., Niloofa, R., Jayarajah, U., De Mel, S., Abeysuriya, V. and Seneviratne, S.L. (2021) Hema-Tological Abnormalities in COVID-19: A Narrative Review. The American Journal of Tropical Medicine and Hygiene, 104, 1188-1201. https://doi.org/10.4269/ajtmh.20-1536
Lucijanic, M., Krecak, I., Soric, E., Sedinic, M., Sabljic, A., Derek, L., et al. (2021) Thrombocytosis in COVID-19 Patients without Myeloproliferative Neoplasms Is Associated with a Better Prognosis but a Higher Rate of Venous Thromboembolism. Blood Cancer Journal, 11, Article No. 189. https://doi.org/10.1038/s41408-021-00585-2
Lindsley, A.W., Schwartz, J.T. and Rothenberg, M.E. (2020) Eosinophil Responses during COVID-19 Infections and Coronavirus Vaccination. Journal of Allergy and Clinical Immunology, 146, 1-7. https://doi.org/10.1016/j.jaci.2020.04.021
Yarali, N., Akcabelen, Y.M., Unal, Y. and Parlakay, A.N. (2021) Hematological Parameters and Morphological Abnormalities of Peripheral Blood in Children with COVID-19. Pediatric Blood & Cancer, 68, e28596. https://doi.org/10.22541/au.159069193.34265275
Bellan, M., Azzolina, D., Hayden, E., Gaidano, G., Pirisi, M., Acquaviva, A., et al. (2021) Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19. Disease Markers, 2021, e8863053.