Research ArticleOpen AccessGoogle Scholar indexed
Radiation associated coronary occlusion: Overlooked as trastuzumab-induced cardiomyopathy
Department of Cardiology, Central Hospital, Izmir, Turkey
Department of Cardiology, Celal Bayar University, Manisa, Turkey
Department of Cardiology, Celal Bayar University, Manisa, Turkey
- 1 Department of Cardiology, Central Hospital, Izmir, Turkey
- 2 Department of Cardiology, Celal Bayar University, Manisa, Turkey
- 3 Department of Cardiology, Celal Bayar University, Manisa, Turkey
Open Journal of Internal Medicine·Volume 03 (2013)·Pages 1–2·Published 22 March 2013·DOI10.4236/ojim.2013.31001
Copy link · social · email
Abstract
Trastuzumab is an agent used for receptor-positive breast cancer. Up to a third of patients treated with trastuzumab might develop cardiomyopathy. Many patients with breast cancer have taken pre- or co-ad ministration of mediastinal radiotherapy. Both of treat ment modalities have toxic effects on myocardium. It may result with diagnostic confusion between radiation-induced CAD (riCAD) and trastuzumab cardiomyopathy in the case with dilated cardiomyopathy. TTE may offer clues of differential diagnosis.
KeywordsCardiomyopathyTrastuzumabRadiation
- Roychoudhuri, R., Robinson, D., Putcha, V., et al. (2007) Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: A population-based study. BMC Cancer, 7, 9-14.
- Guglin, M., Hartlage, G., Reynolds, C., et al. (2009) Trastuzumab-induced cardiomyopathy: Not as benign as it looks? A retrospective study. Journal of Cardiac Failure, 15, 651-657.
- Feng, M., Moran, J.M., Koelling, T., et al. (2011) Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. International Journal of Radiation Oncology, Biology, Physics, 79, 10-18.