Research ArticleOpen AccessGoogle Scholar indexed
Lamotrigine overdose cause skin rash and angioedema
Department of Internal Medicine, Lincoln Medical and Mental Health Center, New York, USA
Department of Internal Medicine, Lincoln Medical and Mental Health Center, New York, USA
- 1 Department of Internal Medicine, Lincoln Medical and Mental Health Center, New York, USA
- 2 Department of Internal Medicine, Lincoln Medical and Mental Health Center, New York, USA
Open Journal of Internal Medicine·Volume 03 (2013)·Pages 63–65·Published 28 May 2013·DOI10.4236/ojim.2013.32016
Copy link · social · email
Abstract
A 23 years old female p resent ed to Lincoln Medical and Mental Health center with skin rash and angioe dema after she received 20 pills of lamotrigine 25 mg, and the patient used to take this medication before two tables a day for many months, after she received the appropriate management she improved. A fter re viewing MEDLINE we found a few case s reported life threatening complications related to lamotrigine in toxication and sudden increase the dose, so we should be aware about these complication s before prescrib ing this medication.
KeywordsLamotrigineOver DoseAngioedema
- French, J.A., Kanner, A.M., Bautista, J., et al. (2004) Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 62, 1252. doi:10.1212/01.WNL.0000123693.82339.FC
- Biton, V., Di Memmo, J., Shukla, R., et al. (2010) Adjunctive lamotrigine XR for primary generalized tonicclonic seizures in a randomized, placebo-controlled study. Epilepsy & Behavior, 19, 352. doi:10.1016/j.yebeh.2010.07.022
- Bowden, C.L., Asnis, G.M., Ginsberg, L.D., et al. (2004) Safety and tolerability of lamotrigine for bipolar disorder. Drug Safety, 27, 173. doi:10.2165/00002018-200427030-00002
- Dichter, M.A. and Brodie, M.J. (1996) New antiepileptic drugs. The New England Journal of Medicine, 334, 1583-1590. doi:10.1056/NEJM199606133342407
- Schaub, J.E., Williamson, P.J., Barnes, E.W. and Trewby, P.N. (1994) Multisystem adverse reaction to lamotrigine (letter). Lancet, 344, 481. doi:10.1016/S0140-6736(94)91818-X
- Yuen, A.W. and Bihari, D.J. (1992) Multiorgan failure and disseminated intravascular coagulation in severe convulsive seizures (letter). Lancet, 340, 618. doi:10.1016/0140-6736(92)92159-D
- Schirop, T.H., Lufft, H., Winkler, M., et al. (1994) Bronchial mucosa reaction in Lyell-Stevens-Johnson syndrome following lamotrigine. Intensivmedizin und Notfallmedizin, 31, 343.
- Harchelroad, F., Lang, D. and Valeriano, J. (1994) Lamotrigine overdose. Veterinary & Human Toxicology, 36, 372.
- Lofton, A.L. and Klein-Schwartz, W. (2004) Evaluation of lamotrigine toxicity reported to poison control centers. The Annals of Pharmacotherapy, 38, 1811-1815. doi:10.1345/aph.1E192