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The nervous system and pH
Education Department, Central Texas Veterans Health Care System Temple, Temple, USA
- 1 Education Department, Central Texas Veterans Health Care System Temple, Temple, USA
Open Journal of Internal Medicine·Volume 03 (2013)·Pages 126–128·Published 11 December 2013·DOI10.4236/ojim.2013.34028
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Abstract
The mix of cellular pumps, channels, transporters, and isoenzymes is genetically inherited. However, the environment has the ability to impact the cellular pumps, channels, transporters, and isoenzymes to some degree. Cellular pumps, channels, transporters and isoenzymes help control cellular pH and vice versa. Therefore possibly the pH in the nervous system is more variable than previously believed. If so, that could explain some of the changes we see in the nervous system.
KeywordsCentral Nervous SystempHGenetic PredispositionEnvironmental TriggersCellular PumpsChannelsTransportersIsoenzymesDementiaParkinsons DiseaseTraumatic Brain Injury
- Nagamatsu, M., Podratz, J., Windebank, A.J. and Low, P.A. (1997) Acidity is involved in the development of neuropathy caused by oxidized cellulose. Journal of the Neurological Sciences, 146, 97-102. http://dx.doi.org/10.1016/S0022-510X(96)00295-X
- Siesjo, B.K. (1985) Acid-base homeostasis in the brain: Physiology, chemistry, and neurochemical pathology. Progress in Brain Research, 63, 121-154. http://dx.doi.org/10.1016/S0079-6123(08)61980-9
- Enciu, A., Gherghiceanu, M. and Popescu, B.O. (2013) Triggers and effectors of oxidative stress at the blood-brain barrier level: Relevance for brain ageing and neurodegeneration. Oxidative Medicine and Cellular Longevity, published online 10.1155/2013/297512.
- Kroll, S., El-Gindi, J., Thanabalasundaram, G., Panpumthong, P., Schrot, S., Hartmann, C. and Galla, H. (2009) Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit. Annals of the New York Academy of Sciences, 1165, 228-239. http://dx.doi.org/10.1111/j.1749-6632.2009.04040.x
- Freiberg, J.M., Kinsella, J. and Sacktor B. (1982) Glucocorticoids increase the Na+-H+ exchange and decrease the Na+ gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles. Proceedings of the National Academy of Sciences of the USA Biochemistry, 79, 4932-4936. http://dx.doi.org/10.1073/pnas.79.16.4932
- Maturu, P., Vaddi D.R., Pannuru, P. and Nallanchakravarthula, V. (2013) Modification of erythrocyte membrane proteins, enzymes and transport mechanisms in chronic alcoholics: An in vivo and in vitro study. Alcohol and Alcoholism. http://dx.doi.org/10.1093/alcalc/agt071
- Kiyatkin, E.A., Brown, P.L. and Wise, R.A. (2002) Brain temperature fluctuation: A reflection of functional neural activation. European Journal of Neuroscience, 16, 164-168. http://dx.doi.org/10.1046/j.1460-9568.2002.02066.x
- Sapolsky, R.M. (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57, 925-935. http://dx.doi.org/10.1001/archpsyc.57.10.925
- Masri, S.W., Muslim, A. and Gubler, C.J. (1988) Isolation of transketolase from rabbit liver and comparison of some of its kinetic properties with transketolase from other sources. Comparative Biochemistry and Physiology, 90B, 167-172.
- Peng, J.H., McGeer, P.L. and McGeer, E.G. (1986) Membrane-bound choline acetyltransferase from human brain: Purification and properties. Neurochemical Research, 11, 959-971. http://dx.doi.org/10.1007/BF00965586