<b>Introduction</b>: In Senegal, the frequency of diabetes mellitus is estimated at 3.2% and its management by the general patrician (gp) is dissatisfied. The objective was to evaluate the decentralized monitoring of diabetes mellitus and other cardiovascular risk factors by a trained general practician. <b>Patients and methods</b>: It was a retrospective, descriptive study conducted from June 1, 2013 to 31 May, 2015 in Dakar, where included the files of subjects with diabetes mellitus regularly followed. The data collected were epidemiological, diagnostic and therapeutic. <b>Results</b>: It was of 125 diabetics patients with a mean age of 56.4 years old. At the inclusion, their diabetes had a mean duration of 6.3 years and a mean average HbA1c of 10.4%. The complications were a neuropathy in 58 cases (46.4%), an arteritis in 46 cases (36.8%), a nephropathy in 16 cases (12.8%) and a retinopathy in 28 cases (22.4%). Other cardiovascular risk factors were an arterial hypertension in 74 cases (59.2%), smoking in 11 cases (8.8%), kidney disease in 16 cases (12.8%), and LDL-cholesterol > 1.6 g/l in 39 cases (31.2%). In total, 87 patients (69.6%) were at high cardiovascular risk and among them, 81.6% had LDL-cholesterol > 1g/l. At inclusion, anti-diabetic treatment was oral mono-therapy in 53 cases (42.4%), an insulin therapy in 49 cases (39.2%). After 12 month of follow-up, the dual therapy anti-diabetic was increased from 13.6% to 34.4%. The others associated drugs were anti-hypertensives in 72 cases (57.6%), statins in 29 cases (23.2%) and anti-platelet agent in 46 cases (36.8%). Only 31.2% of the patients with nephropathy were under the renin angiotensin system blockers. Statins and the anti-platelet agents were prescribed respectively at 25.2% and 47.1% of the 87 patients at high cardiovascular risk. During follow-up, the target HbA1c < 7% was reached in 76 cases (60.8%). <b>Conclusion</b>: our study shows the importance and the interest of a trained general practician for the management of non-communicable diseases. However, it would be necessary to strengthen training in the care of other cardiovascular risk factors.
Diop, S.N. and Diédhiou, D. (2015) Diabetes Mellitus in Sub-Saharan Africa: Epidemiological and Socioeconomic Aspects. Médecine et Maladies Infectieuses, 9, 123-129. https://doi.org/10.1016/S1957-2557(15)30030-4
Sobngwi, E., Ndour-Mbaye, M., Boateng, K.A., et al. (2012) Type 2 Diabetes Control and Complications in Specialized Diabetes Care Centers of Six Sub-Saharan African Countries: The Diabcare Africa study. Diabetes Research and Clinical Practice, 95, 30-36. https://doi.org/10.1016/j.diabres.2011.10.018
Ndour-Mbaye, M., Sarr, A., Diop, S.N., et al. (2011) DiabCare Senegal: A Survey on Diabetes Management in Senegal. Médecine et Maladies Infectieuses, 5, 85-89.
Afssaps, High Authority of Health. (2006) Medicinal Treatment of the Type 2 Diabetes. Recommendations.
James, P.A., Oparil, S., Carter, B.L., et al. (2014) Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report from the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). The Journal of the American Medical Association, 311, 507-520. https://doi.org/10.1001/jama.2013.284427
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation, 106, 3143-3421.
Cole, T.J., Bellizzi, M.C., Flegal, M.E., et al. (2000) Establishing a Standard Definition for Overweight and Obesity Worldwide: International Survey. British Medical Journal, 320, 1240-1243. https://doi.org/10.1136/bmj.320.7244.1240
American Diabetes Association (ADA) (2008) Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy. Diabetes Care, 31, S1-S11.
Gagliardino, J.J., Atanasov, P.K., Chan, J.C.N., et al. (2017) Resource Use Associated with Type 2 Diabetes in Africa, the Middle East, South Asia, Eurasia and Turkey: Results from the International Diabetes Management Practice Study (IDMPS). BMJ Open Diabetes Research and Care, 5, 1-10. https://doi.org/10.1136/bmjdrc-2016-000297
Diop, S.N., Wade, A., Lokrou, A., Diédhiou, D. and Adoueni, V.K. (2013) Management of Type 2 Diabetes in Clinical Practices in Sub-Saharan Africa: Results of the AMAR-AFO Study in Senegal and Ivory Cost. Médecine et Maladies Infectieuses, 7, 363-367. https://doi.org/10.1016/S1957-2557(13)70603-5
Gaede, P., Lund-Andersen, H., Parving, H.H. and Pedersen, O. (2008) Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes. The New England Journal of Medicine, 358, 580-591. https://doi.org/10.1056/NEJMoa0706245
Adebamowo, S.N., Adeyemo, A.A., Tekola-Ayele, F., et al. (2016) Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations. Frontiers in Endocrinology, 7, 1-6. https://doi.org/10.3389/fendo.2016.00050
Bos, M. and Agyemang, C. (2013) Prevalence and Complications of Diabetes Mellitus in Northern Africa, a Systematic Review. BMC Public Health, 13, 387. https://doi.org/10.1186/1471-2458-13-387
Burgess, P.I., MacCormick, I.J.C., Harding, S.P., Bastawrous, A., Beare, N.A.V. and Garner, P. (2013) Epidemiology of Diabetic Retinopathy and Maculopathy in Africa: A Systematic Review. Diabetic Medicine, 30, 399-412. https://doi.org/10.1111/j.1464-5491.2012.03756.x
Noubiap, J.J.N., Naidoo, J. and Kengne, A.P. (2015) Diabetic Nephropathy in Africa: A Systematic Review. World Journal of Diabetes, 6, 759-773. https://doi.org/10.4239/wjd.v6.i5.759
Ragot, S., Saulnier, P.J., Velho, G., et al. for the SURDIAGENE and DIABHYCAR Study Groups (2016) Dynamic Changes in Renal Function Are Associated with Major Cardiovascular Events in Patients with Type 2 Diabetes. Diabetes Care, 39, 1259-1266. https://doi.org/10.2337/dc15-2607
Dahjio, Y., Noubiap, J.J.N., Azabji-Kenfack, M., et al. (2016) Impact of a 12-Week Aerobic Exercise Training Program on Anthropometric and Metabolic Parameters of a Group of Type 2 Diabetes Cameroonian Women Aged ≥50 Years. Annals of Translational Medicine, 4, 364. https://doi.org/10.21037/atm.2016.09.26
Li, G., Zhang, P., Wang, J., et al. (2008) The Long-Term Effect of Lifestyle Interventions to Prevent Diabetes in the China Da Qing Diabetes Prevention Study: A 20-Year Follow-Up Study. Lancet, 371, 1783-1789. https://doi.org/10.1016/S0140-6736(08)60766-7
The Look AHEAD Research Group. (2010) Long Term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals with Type 2 Diabetes: Four Year Results of the Look AHEAD Trial. Archives of Internal Medicine, 170, 1566-1575.
American Diabetes Association (2017) Lifestyle Management. In Standards of Medical Care in Diabetes 2017. Diabetes Care, 40, S33-S43. https://doi.org/10.2337/dc17-s007
Harper, W., Clement, M., Goldenberg, R., et al. (2013) For the Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Pharmacologic Management of Type 2 Diabetes. Canadian Journal of Diabetes, 37, S61-S68. https://doi.org/10.1016/j.jcjd.2013.01.021
American Diabetes Association (2017) Pharmacologic Approaches to Glycemic Treatment. In Standards of Medical Care in Diabetes 2017. Diabetes Care, 40, S64-S74. https://doi.org/10.2337/dc17-s011
American Diabetes Association. (2017) Cardiovascular Disease and Risk Management. In Standards of Medical Care in Diabetes 2017. Diabetes Care, 40, S75-S87.
Cholesterol Treatment Trialists’ Collaborators, Kearney, P.M., Blackwell, L., Collins R., et al. (2008) Efficacy of Cholesterol-Lowering Therapy in 18.686 People with Diabetes in 14 Randomized Trials of Statins: A Meta-Analysis. Lancet, 371, 117-125. https://doi.org/10.1016/S0140-6736(08)60104-X
Huxley, R.R., Peters, S.A.E., Mishra, G.D. and Woodward, M. (2015) Risk of All-Cause Mortality and Vascular Events in Women versus Men with Type 1 Diabetes: A Systematic Review and Meta-Analysis. The Lancet Diabetes & Endocrinology, 3, 198-206. https://doi.org/10.1016/S2213-8587(14)70248-7
Peters, S.A.E., Huxley, R.R. and Woodward, M. (2014) Diabetes as Risk Factor for Incident Coronary Heart Disease in Women Compared with Men: A Systematic Review and Meta-Analysis of 64 Cohorts Including 858,507 Individuals and 28,203 coronary Events. Diabetologia, 57, 1542-1551. https://doi.org/10.1007/s00125-014-3260-6
Kalyani, R.R., Lazo, M., Ouyang, P., et al. (2014) Sex Differences in Diabetes and Risk of Incident Coronary Artery Disease in Healthy Young and Middle-Aged Adults. Diabetes Care, 37, 830-838. https://doi.org/10.2337/dc13-1755
Peters, S.A.E., Huxley, R.R. and Woodward, M. (2014) Diabetes as a Risk Factor for Stroke in Women Compared with Men: A Systematic Review and Meta-Analysis of 64 Cohorts, Including 775,385 Individuals and 12,539 Strokes. Lancet, 383, 1973-1980. https://doi.org/10.1016/S0140-6736(14)60040-4