Trace elements naturally occur in marine ecosystems, with some playing vital roles in biological processes, while others pose toxicological risks to humans and marine organisms. This study presents a comprehensive evaluation of essential and trace metals (Fe, Zn, Cu, Cr, Mn, Ca, Mg) in edible and non-edible tissues of marine species collected along the Albanian coastline. Concentrations were analyzed to assess nutritional benefits, pollution levels, and potential human health risks using indicators such as Estimated Daily Intake (EDI), Target Hazard Quotient (THQ), Hazard Index (HI) and cluster analysis. Results revealed that most species are nutritionally beneficial and safe for consumption, with metal concentrations generally below safety thresholds. However, higher concentrations in liver and gill tissues indicate tissue-specific bioaccumulation. Cluster analysis highlighted differences in metal profiles by species and tissue type, aiding in source discrimination and future monitoring. Overall, the findings support the consumption of Albanian marine species while emphasizing the importance of monitoring specific metals and organs.
Rainbow, P.S. (2002) Trace Metal Concentrations in Aquatic Invertebrates: Why and So What? Environmental Pollution , 120, 497-507. https://doi.org/10.1016/s0269-7491(02)00238-5
Sadiq, M. (1992) Toxic Metal Chemistry in Marine Environments. Marcel Dekker.
Alloway, B.J. (2013) Heavy Metals in Soils: Trace Metals and Metalloids in Soils and Their Bioavailability. Springer.
Tchounwou, P.B., Yedjou, C.G., Patlolla, A.K. and Sutton, D.J. (2012) Heavy Metal Toxicity and the Environment. In: Luch, A., Ed., Molecular , Clinical and Environmental Toxicology , Springer, 133-164. https://doi.org/10.1007/978-3-7643-8340-4_6
ATSDR (Agency for Toxic Substances and Disease Registry) (2022) Toxicological Profiles. U.S. Department of Health and Human Services, Public Health Service.
Burger, J. and Gochfeld, M. (2005) Heavy Metals in Commercial Fish in New Jersey. Environmental Research , 99, 403-412. https://doi.org/10.1016/j.envres.2005.02.001
Censi, P., Spoto, S.E., Saiano, F., Sprovieri, M., Mazzola, S., Nardone, G., et al. (2006) Heavy Metals in Coastal Water Systems. A Case Study from the Northwestern Gulf of Thailand. Chemosphere , 64, 1167-1176. https://doi.org/10.1016/j.chemosphere.2005.11.008
Tortorici, F. (2025) Biomarine Concretions, as an Investigation Tool for Expert Purposes. Journal of Environmental Science and Agricultural Research , 3, 1-2. https://doi.org/10.61440/jesar.2025.v3.59
Phillips, D.J.H. and Rainbow, P.S. (1993) Biomonitoring of Trace Aquatic Contaminants. Elsevier.
Storelli, M.M., Storelli, A., D’Addabbo, R., Marano, C., Bruno, R. and Marcotrigiano, G.O. (2002) Trace Elements in Loggerhead Turtles ( Caretta caretta ) from the East-ern Mediterranean Sea: Overview and Evaluation. Environmental Pollution , 119, 145-149.
FAO/WHO (2011). Joint FAO/WHO Food Standards Programme Codex Committee on Contaminants in Foods. FAO/WHO.
Rejomon, G., Nair, M. and Joseph, T. (2009) Trace Metal Dynamics in Fishes from the Southwest Coast of India. Environmental Monitoring and Assessment , 167, 243-255. https://doi.org/10.1007/s10661-009-1046-y
WHO (World Health Organization) (1996) Trace Elements in Human Nutrition and Health. WHO.
Maret, W. (2013) Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life. Advances in Nutrition , 4, 82-91. https://doi.org/10.3945/an.112.003038
Tapiero, H. and Tew, K.D. (2003) Trace Elements in Human Physiology and Pathology: Zinc and Metallothioneins. Biomedicine & Pharmacotherapy , 57, 399-411. https://doi.org/10.1016/s0753-3322(03)00081-7
Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B.B. and Beeregowda, K.N. (2014) Toxicity, Mechanism and Health Effects of Some Heavy Metals. Interdisciplinary Toxicology , 7, 60-72. https://doi.org/10.2478/intox-2014-0009
Gozzelino, R., Jeney, V. and Soares, M.P. (2010) Mechanisms of Cell Protection by Heme Oxygenase-1. Annual Review of Pharmacology and Toxicology , 50, 323-354. https://doi.org/10.1146/annurev.pharmtox.010909.105600
Gaetke, L. (2003) Copper Toxicity, Oxidative Stress, and Antioxidant Nutrients. Toxicology , 189, 147-163. https://doi.org/10.1016/s0300-483x(03)00159-8
Plum, L.M., Rink, L. and Haase, H. (2010) The Essential Toxin: Impact of Zinc on Human Health. International Journal of Environmental Research and Public Health , 7, 1342-1365. https://doi.org/10.3390/ijerph7041342
Aschner, M., Erikson, K.M. and Dorman, D.C. (2005) Manganese Dosimetry: Species Differences and Implications for Neurotoxicity. Critical Reviews in Toxicology , 35, 1-32. https://doi.org/10.1080/10408440590905920
Clarkson, T.W. and Magos, L. (2006) The Toxicology of Mercury and Its Chemical Compounds. Critical Reviews in Toxicology , 36, 609-662. https://doi.org/10.1080/10408440600845619
Godt, J., Scheidig, F., Grosse-Siestrup, C., Esche, V., Brandenburg, P., Reich, A., et al. (2006) The Toxicity of Cadmium and Resulting Hazards for Human Health. Journal of Occupational Medicine and Toxicology , 1, Article No. 22. https://doi.org/10.1186/1745-6673-1-22
IARC (International Agency for Research on Cancer) (2012) Arsenic, Metals, Fibres and Dusts. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100C.
EFSA (European Food Safety Authority) (2010) Scientific Opinion on Lead in Food. EFSA Journal , 8, 1570.
Pandey, P., Shukla, S., Yadav, S. S. and Singh, S. (2023) A Review on Toxicity and Health Effect Mechanism by Heavy Metals. International Journal of Research and Analytical Reviews , 10, Article 119128. https://www.researchgate.net/publication/374372118
van der Oost, R., Beyer, J. and Vermeulen, N.P.E. (2003) Fish Bioaccumulation and Biomarkers in Environmental Risk Assessment: A Review. Environmental Toxicology and Pharmacology , 13, 57-149. https://doi.org/10.1016/s1382-6689(02)00126-6
Neff, J.M. (1997) Ecotoxicology of Arsenic in the Marine Environment. Environmental Toxicology and Chemistry , 16, 917-927. https://doi.org/10.1002/etc.5620160511
Tüzen, M. (2003) Determination of Heavy Metals in Fish Samples of the Middle Black Sea (Turkey) by Graphite Furnace Atomic Absorption Spectrometry. Food Chemistry , 80, 119-123. https://doi.org/10.1016/s0308-8146(02)00264-9
Bebianno, M.J. (1998) Effects of Pollutants on the Immune System of Bivalves. Environmental Toxicology and Chemistry , 17, 27-33.
Amiard, J., Amiardtriquet, C., Barka, S., Pellerin, J. and Rainbow, P. (2006) Metallothioneins in Aquatic Invertebrates: Their Role in Metal Detoxification and Their Use as Biomarkers. Aquatic Toxicology , 76, 160-202. https://doi.org/10.1016/j.aquatox.2005.08.015
WHO (World Health Organization) (2007) Exposure to Mercury: A Major Public Health Concern. WHO.
Viarengo, A. (1989) Heavy Metals in Marine Invertebrates: Mechanisms of Regulation and Toxicity at the Cellular Level. Aquatic Sciences , 1, 295-317.
Wang, S. and Shi, X. (2001) Molecular Mechanisms of Metal Toxicity and Carcinogenesis. Molecular and Cellular Biochemistry , 222, 3-9. https://doi.org/10.1023/a:1017918013293