Nephritis Syndrome Tubulo-Intertitial and Uveitis (Tinu Syndrome): About 2 Cases

Abstract

Introduction: Tubular and interstitial nephropathy syndrome with uveitis or TINU syndrome is a rare association. Patients and methods: We have listed cases in which the clinical-biological picture and histology were consistent with this syndrome. Results: Two cases were retained: These were two female patients whose mean age at diagnosis was 16 years. The inaugural symptoms were bilateral anterior uveitis in two cases. The time to onset of renal signs: was 4 to 2 weeks months. Acute kidney failure was reported in both cases with a mean creatinine of 36.4 mg/l. An average proteinuria of 1.1 g/24 h associated with aseptic leukocyturia in one case/2 and glycosuria normoglycemic in 1 case/2. Non inflammatory syndrome specific with inflammatory anemia is reported in both cases. Kidney puncture biopsy confirmed the diagnosis with nephropathy diffuse polymorphic tubulointerstitial and immunofluorescence negative in both cases. Oral corticosteroid therapy (1 mg/kg per day) was started for 4 to 6 months. Both patients received initial local corticosteroid therapy for uveitis. The outcome was favorable under treatment with remission complete. Kidney function recovered after 6 months with an average serum creatinine of 6 mg/l. Discussion: The incidence of TINU syndrome appears to be underestimated in the literature. It is believed to be an autoimmune disease. The positive diagnosis is based on clinical, biological and histological. An etiological investigation in search of disease systemic is necessary before making the diagnosis. There is no codified treatment. The prognosis is favorable in the majority of cases. Conclusion: Investigation of renal function is necessary for any patient.