Estimation of Glomerular Filtration Rate: Which Formula to Apply in G-Spot Subjects Aged 1 - 17 Years?
- 1 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 2 Medical biology Laboratory Service of the Point G University Hospital, Bamako, Mali
- 3 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 4 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 5 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 6 Medical biology Laboratory Service of the Point G University Hospital, Bamako, Mali
- 7 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 8 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 9 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
- 10 Nephrology Department of the Regional Hospital of Kayes, Kayes, Mali
- 11 Nephrology Department of the Regional Hospital of Kayes, Kayes, Mali
- 12 Nephrology Department of the Regional Hospital of Kayes, Kayes, Mali
- 13 Medical biology Laboratory Service of the Point G University Hospital, Bamako, Mali
- 14 Nephrology and Hemodialysis Department of the Point G University Hospital, Bamako, Mali
Abstract
Introduction: Morbidity and mortality in paediatric practice is dominated in Africa by malaria, diarrhoeal diseases and acute respiratory infections. Aim: In order to evaluate the Glomerular Filtration Rate (GFR) with the formulas commonly used by medical laboratories, we proposed to undertake this study. Patients and Method: This was a descriptive, prospective and cross-sectional study conducted at the PA and KA medical biology laboratory in Bamako Hamdalaye ACI 2000 in collaboration with the medical biology and hospital hygiene laboratory service at the Point G University Hospital. Results: During the study period, we recruited 360 subjects, 189 of whom were male (52.5%) and 171 female (47.5%). The mean age was 8.75 ± 4.8 years with extremes of 1 and 17 years. Subjects aged 15 to 17 years were the most numerous. The reference means GFR of the subjects according to age was with the SCHWARTZ formula 179.16 ± 50.47 with extremes of 173.93 and 184.39; with CKD-Epi 37.63 ± 11.25 with extremes of 36.46 and 38.79; with MAYO 107.87 ± 18.11 with extremes of 105.99 and 109.75 and MDRD 350.83 ± 251.15 with extremes of 324.79 and 376.86. Conclusion: The Mayo formula showed a better distribution around the mean than other formulas for estimating the glomerular filtration rate.
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