Introduction : Infective endocarditis (IE) is a complication associated with high mortality in chronic hemodialysis patients. The aim of our study is to describe the clinical, radiological, microbiological characteristics, and risk factors of mortality in hemodialysis patients with infective endocarditis. Methods : A retrospective study from November 2019 to November 2021 including hemodialysis patients with IE hospitalized in Ibn Sina hospital center in Rabat. Results : Eighteen hemodialysis patients were included. Mean age was 49.5 ± 18 years, sex ratio was 0.8. Catheters were the access sites most commonly used (72.3%). Median duration of hemodialysis was 12 [6; 24] months. Staphylococcus species is major causative bacteria in 60%. The mitral valve was the most commonly affected (44%). Frequent complications including valve insufficiency (50%), septic embolism (66.7%). Four patients underwent surgery and eight died during hospitalization (44.5%). Mitral localization of vegetation was the only factor significantly associated with mortality in our study (P < 0.05). Conclusion : The catheter was the most commonly used access site compared to the arteriovenous fistula. This confirms that it’s the vascular access of choice for his low rate of infectious complication compared to the catheter.
Brescia, M.J., Cimino, J.E., Appel, K. and Hurwich, B.J. (1966) Chronic Hemodialysis Using Venipuncture and a Surgically Created Arteriovenous Fistula. The New England Journal of Medicine, 275, 1089-1092. https://doi.org/10.1056/NEJM196611172752002
Bentata, Y. (2017) Physiopathological Approach to Infective Endocarditis in Chronic Hemodialysis Patients: Left Heart versus Right Heart Involvement. Renal Failure, 39, 432-439. https://doi.org/10.1080/0886022X.2017.1305410
Abbott, K.C. and Agodoa, L.Y. (2002) Hospitalizations for Bacterial Endocarditis after Initiation of Chronic Dialysis in the United States. Nephron, 91, 203-209. https://doi.org/10.1159/000058393
Topani, A., Carstina, D., et al. (2015) Assessment of the Duke Criteria for the Diagnosis of Infective Endocarditis after Twenty-Years. An Analysis of 241 Cases. Clujul Medical, 88, 321-326. https://doi.org/10.15386/cjmed-469
Lafrance, J.P., Rahme, E., et al. (2008) Vascular Access-Related Infections: Definitions, Incidence Rates, and Risk Factors. American Journal of Kidney Diseases, 52, 982-993. https://doi.org/10.1053/j.ajkd.2008.06.014
Sarnak, M.J. and Jaber, B.L. (2000) Mortality Caused by Sepsis in Patients with End-Stage Renal Disease Compared with the General Population. Kidney International, 58, 1758-1764. https://doi.org/10.1111/j.1523-1755.2000.00337.x
Ponce, P., Cruz, J., et al. (2007) A Prospective Study on Incidence of Bacterial Infections in Portuguese Dialysis Units. Nephron Clinical Practice, 107, c133-c138. https://doi.org/10.1159/000110033
O’Seaghdha, C.M. and Foley, R.N. (2005) Septicemia, Access, Cardiovascular Disease, and Death in Dialysis Patients. Peritoneal Dialysis International, 25, 534-540. https://doi.org/10.1177/089686080502500604
Wakasugi, M., Kawamura, K., et al. (2012) High Mortality Rate of Infectious Diseases in Dialysis Patients: A Comparison with the General Population in Japan. Therapeutic Apheresis and Dialysis, 16, 226-231. https://doi.org/10.1111/j.1744-9987.2012.01062.x
Goodkin, D.A., Bragg-Gresham, J.L., Koenig, K.G., et al. (2004) Association of Comorbid Conditions and Mortality in Hemodialysis Patients in Europe, Japan, and the United States: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Journal of the American Society of Nephrology, 14, 3270-3277. https://doi.org/10.1097/01.ASN.0000100127.54107.57
Chaudry, M.S., Carlson, N., Gislason, G.H., et al. (2017) Risk of Infective Endocarditis in Patients with End Stage Kidney Disease. Clinical Journal of the American Society of Nephrology, 12, 1814-1822. https://doi.org/10.2215/CJN.02320317
Bhatia, N., Agrawal, S., Garg, A., et al. (2017) Trends and Outcomes of Infective Endocarditis in Patients on Dialysis. Clinical Cardiology, 40, 423-429. https://doi.org/10.1002/clc.22688
Baroudi, S., Qazi, R.A., Lentine, K.L. and Bastani, B. (2008) Infective Endocarditis in Haemodialysis Patients: 16-Year Experience at One Institution. NDT Plus, 1, 253-256. https://doi.org/10.1093/ndtplus/sfn026
Shroff, G.R., Herzog, C.A., Ma, J.Z. and Collins, A.J. (2004) Long-Term Survival of Dialysis Patients with Bacterial Endocarditis in the United States. American Journal of Kidney Diseases, 44, 1077-1082. https://doi.org/10.1053/j.ajkd.2004.08.030
Janga, K.C., Sinha, A., et al. (2017) Nephrologists Hate the Dialysis Catheters: A Systemic Review of Dialysis Catheter Associated Infective Endocarditis. Case Reports in Nephrology, 2017, Article ID: 9460671. https://doi.org/10.1155/2017/9460671
Spiliopoulos, K., Giamouzis, G., Haschemi, A., et al. (2014) Surgical Management of Infective Endocarditis: Early and Long-Term Mortality Analysis. Single-Center Experience and Brief Literature Review. Hellenic Journal of Cardiology, 55, 462-474.
Mermel, L.A., Allon, M., et al. (2009) Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases, 49, 1-45. https://doi.org/10.1086/599376
Doulton, T., Sabharwal, N., Cairns, H.S., et al. (2003) Infective Endocarditis in Dialysis Patients: New Challenges and Old. Kidney International, 64, 720-727. https://doi.org/10.1046/j.1523-1755.2003.00136.x
McCarthy, J.T. and Steckelberg, J.M. (2000) Infective Endocarditis in Patients Receiving Long-Term Hemodialysis. Mayo Clinic Proceedings, 75, 1008-1014. https://doi.org/10.4065/75.10.1008
Spies, C., Madison, J.R. and Schatz, I.J. (2004) Infective Endocarditis in Patients with End-Stage Renal Disease: Clinical. Archives of Internal Medicine, 164, 71-75. https://doi.org/10.1001/archinte.164.1.71
Gallacher, P.J., McAllister, D.A., et al. (2021) Infective Endocarditis Hospitalizations and Outcomes in Patients with End-Stage Kidney Disease: A Nationwide Data-Linkage Study. Journal of the American Heart Association, 10, e022002. https://doi.org/10.1161/JAHA.121.022002
Chaudry, M.S., Gislason, G.H., et al. (2018) The Impact of Hemodialysis on Mortality Risk and Cause of Death in Staphylococcus aureus Endocarditis. BMC Nephrology, 19, Article No. 216. https://doi.org/10.1186/s12882-018-1016-0
Chang, C.F., Kuo, B.I., Chen, T.L., Yang, W.C., Lee, S.D. and Lin, C.C. (2004) Infective Endocarditis in Maintenance Hemodialysis Patients: Fifteen Years’ Experience in One Medical Center. Journal of Nephrology, 17, 228-235.
Nori, U.S., Manoharan, A., Thornby, J.I., et al. (2006) Mortality Risk Factors in Chronic Haemodialysis Patients with Infective Endocarditis. Nephrology Dialysis Transplantation, 21, 2184-2190. https://doi.org/10.1093/ndt/gfl200
Suwa, Y., Miyasaka, Y., et al. (2020) Predictors of In-Hospital Mortality in Patients with Infective Endocarditis. Acta Cardiologica, 76, 642-649. https://doi.org/10.1080/00015385.2020.1767368
Delgado-Rodriguez, M., Medina-Cuadros, M., Gomez-Ortega, A., et al. (2002) Cholesterol and Serum Albumin Levels as Predictors of Cross Infection, Death, and Length of Hospital Stay. The Archives of Surgery, 137, 805-812. https://doi.org/10.1001/archsurg.137.7.805