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Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

¹ Nephrology Unit of Mali GAVARDO Hospital in Sebénicoro, Bamako, Mali
² National Center for Scientific and Technological Research (CNRST), Bamako, Mali
³ Nephrology Unit of Mali GAVARDO Hospital in Sebénicoro, Bamako, Mali
⁴ Nephrology Unit of the Fousseyni DAOU Hospital, Kayes, Mali
⁵ Nephrology Department of the Soissons Hospital, Soissons, France
⁶ Nephrology Department of the Soissons Hospital, Soissons, France
⁷ Nephrology Department of the Soissons Hospital, Soissons, France
⁸ Nephrology and Hemodialysis Department of the UHC du Point G, Bamako, Mali
⁹ Faculty of Medicine of Bamako, Bamako, Mali
¹⁰ Nephrology and Hemodialysis Department of the UHC du Point G, Bamako, Mali
¹¹ Nephrology Unit of Sikasso Hospital, Sikasso, Mali
¹² Nephrology Unit of Somino DOLO Hospital, Mopti, Mali
¹³ Nephrology and Hemodialysis Department of the UHC du Point G, Bamako, Mali
¹⁴ Nephrology Unit of Somino DOLO Hospital, Mopti, Mali
¹⁵ National Center for Scientific and Technological Research (CNRST), Bamako, Mali
¹⁶ Nephrology and Hemodialysis Department of the UHC du Point G, Bamako, Mali
¹⁷ Nephrology Unit of Somino DOLO Hospital, Mopti, Mali
¹⁸ Nephrology Unit of Somino DOLO Hospital, Mopti, Mali
¹⁹ Faculty of Medicine of Bamako, Bamako, Mali

Open Journal of Nephrology·Volume 12 (2022)·Pages 235–240·Published 28 July 2022·DOI10.4236/ojneph.2022.123024

Abstract

Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).

KeywordsAcute Renal FailureParacetamol IntoxicationHemodialysis

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Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report

Abstract

References (17)