Quality of Life in Chronic Kidney Disease Patients on Dialysis at the University Teaching Hospital-Adult Hospital, Lusaka, Zambia — Oak Academic Publishing
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Quality of Life in Chronic Kidney Disease Patients on Dialysis at the University Teaching Hospital-Adult Hospital, Lusaka, Zambia
School of Health, Rusangu University, Monze, Zambia
,
Department of Basic and Clinical Nursing Sciences, University of Zambia, Lusaka, Zambia
,
Department of Basic and Clinical Nursing Sciences, University of Zambia, Lusaka, Zambia
1 School of Health, Rusangu University, Monze, Zambia
2 Department of Basic and Clinical Nursing Sciences, University of Zambia, Lusaka, Zambia
3 Department of Basic and Clinical Nursing Sciences, University of Zambia, Lusaka, Zambia
Introduction: The importance of determining health related quality of life in Chronic Kidney Disease patients on dialysis is well established. However, research was limited in establishing the health related quality of life for chronic kidney disease patients on dialysis at University Teaching Hospital-Adult Hospital. Further the effects of haemoglobin levels and adequacy of dialysis on their health related quality of life were unknown. Therefore, the study sought to answer a research question: what is the health-related Quality of Life for Chronic Kidney Disease patients on dialysis at University Teaching Hospital? Method: The study was an analytical cross-sectional study that used a census sampling method. The study participants comprised of 104 patients who sought dialysis services (2020-2021) from the University Teaching Hospital-Renal Unit in Lusaka, Zambia. A structured Kidney Disease Quality of Life Short form (KDQOL-SF 36) was used to collect data. The Data was analyzed using the Statistics and Data software version 13, Chi-square tests, and logistic regression analysis was employed to analyse the data. A confidence interval of 95% was set with a significant level of 0.05. Results: The study included 104 Chronic Kidney Disease patients from the Dialysis Unit at University Teaching Hospital in Lusaka, Zambia. Two-thirds (68%) of the patients had a good overall health-related quality of life with the biological wellbeing having exceptionally high scores. The male gender (66.7%), unemployment (69.4%), and low haemoglobin levels (77.8%) were identified as factors associated with poor health-related quality of life. Conclusion: The health related quality of life of Chronic Kidney Disease patients at University Teaching Hospital was good. Low haemoglobin levels, age, male sex and unemployment were found to be factors associated with poor health related quality of life. Integration of health-related quality of life assessment for Chronic Kidney disease patients on dialysis in routine care is paramount. Particular focus should be on patients presenting with low haemoglobin levels, age, male sex and unemployment for timely interventions.
KeywordsHealth-Related Quality of LifeDialysisChronic Kidney DiseaseAde-quacy of DialysisHaemoglobin Levels
Webster, A.C., Nagler, E.V., Morton, R.L. and Masson, P. (2016) Chronic Kidney Disease. The Lancet, 389, 1238-1252. https://doi.org/10.1016/S0140-6736(16)32064-5
Luyckx, V.A., Tonelli, A. and Stanifer, J.W. (2018) The Global Burden of Kidney Disease and the Sustainable Development Goals. Bulletin of the World Health Organization, 96, 414-422. https://doi.org/10.2471/BLT.17.206441
Liyanage, T., Ninomiya, T., Jha, V., Neal, B., Patrice, H.M., Okpechi, I., Zhao, M., Lv, J., Garg, A.X., Knight, J., Rodgers, A., Gallagher, M., Kotwal, S., Cass, A. and Perkovic, V. (2015) Worldwide Access to Treatment for End-Stage Kidney Disease: A Systematic Review. The Lancet, 385, 1975-1982. https://doi.org/10.1016/S0140-6736(14)61601-9
Lozano, R., Naghavi, M., Foreman, K., et al. (2012) Global and Regional Mortality from 235 Causes of Death for 20 Age Groups in 1990 and 2010: A Systematic Analysis for the Global Burden of Disease Study. The Lancet, 380, 2095-2128. https://doi.org/10.1016/S0140-6736(12)61728-0
Kaze, A.D., llori, T., Jaar, B.G. and Echouffo-Tcheugui, J.B. (2018) Burden of Chronic Kidney Disease on the African Continent: A Systematic Review and Meta-Analysis. Biomed Central Nephrology, 19, Article No. 125. https://doi.org/10.1186/s12882-018-0930-5
Ene-Iordache, B., Perico, N., Bikbov, B., Carminati, S., Remuzzi, A., Perna, A., Islam, N., Bravo, R.F., Aleckovic-Halilovic, M., Zou, H., Zhang, L., Gouda, Z., Tchokhonelidze, I., Abraham, G., Mahdavi-Mazdeh, M., Gallieni, M., Codreanu, I., Togtokh, A., Sharma, S.K., Koirala. P., Uprety, S., Ulasi, I. and Remuzzi, G. (2016) Chronic Kidney Disease and Cardiovascular Risk in Six Regions of the World (ISN-KDDC): A Cross-Sectional Study. The Lancet Global Health, 4, 307-319. https://doi.org/10.1016/S2214-109X(16)00071-1
Garcia-Garcia, G. and Jha, V. (2015) Chronic Kidney Disease in Disadvantaged Populations: The Case of Africa. African Journal of Primary Health Care and Family Medicine, 7, Article No. 839. https://doi.org/10.4102/phcfm.v7i1.839
Bikbov, B. and Vos, T. (2020) Global, Regional, and National Burden of Chronic Kidney Disease, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet, 395, 709-733. https://doi.org/10.1016/S0140-6736(20)30045-3
Mazyanga, M.L. (2018) Chronic Kidney Disease—Should We Be Concerned? Health Press Zambia Bulletin, 2, 1-3.
Thenmozhi, P. (2017) Quality of Life of Patients Undergoing Haemodialysis. Asian Journal of Pharmaceutical and Clinical Research, 11, 219-223. https://doi.org/10.22159/ajpcr.2018.v11i4.24007
Joshi, U., Subedi, R., Poudel, P., Ghimire, P.R., Panta, R. and Sigdel, M.R. (2017) Assessment of Quality of Life in Patients Undergoing Hemodialysis Using WHO-QOL-Bref Questionnaire: A Multicenter Study. International Journal of Nephrology and Renovascular Disease, 10, 195-203. https://doi.org/10.2147/IJNRD.S136522
Pan, C.W, Wu, Y., Xu, B.X. and Wang, P. (2018) Health-Related Quality of Life and Its Factors of Haemodialysis Patients in Suzhou, China. Blood Purification, 45, 327-333. https://doi.org/10.1159/000485962
Zyoud, S.H., Daraghmeh, D.N., Mezyed, D.O., Khdeir, R.L., Sawafta, M.N., Ayaseh, N.A., Tabeeb, G.H., Sweileh, W.M., Awang, R. and Al-Jabi, S.W. (2016) Factors Affecting Quality of Life in Patients on Haemodialysis: A Cross-Sectional Study from Palestine. Biomed Central Nephrology, 17, Article No. 44. https://doi.org/10.1186/s12882-016-0257-z
Wan, E.Y., Chen, J.Y., Choi, E.P., Wong, C.K.H., Chan, A.K.C., Chan, K.H.Y. and Lam, C.L.K. (2015) Patterns of Health-Related Quality of Life and Associated Factors in Chinese Patients Undergoing Haemodialysis. Health Quality of Life Outcomes, 13, Article No. 108. https://doi.org/10.1186/s12955-015-0308-3
Voskamp, M., van Diepen, M., Evans, M., Caskey, F.J., Torino, C., Postorino, M., Szymczak, M., Klinger, M., Wallquist, C., van de Luijtgaarden, M.W.M., Chesnaye, N.C., Wanner, C., Jager, K.J. and Dekker, F.W. (2019) The Impact of Symptoms on Health-Related Quality of Life in Elderly Pre-Dialysis Patients: Effect and Importance in the EQUAL Study. Nephrology Dialysis Transplantation, 34, 1707-1715. https://doi.org/10.1093/ndt/gfy167
Porter, A.C., Lash, J.P., Xie, D., Pan, Q., DeLuca, J., Kanthety, R., Kusek, J.W., Lora, C.M., Nessel, L., Ricardo, A.C., Nunes, J.W., Fischer, M.J. and the CRIC Study Investigators (2016) Predictors and Outcomes of Health-Related Quality of Life in Adults with CKD. Clinical Journal of the American Society of Nephrology, 11, 1154-1162. https://doi.org/10.2215/CJN.09990915
Dimova, R., Keskinova, D., Tzekov, V. and Ginova-Noncheva, G. (2019) Health-Related Quality of Life in End-Stage Renal Disease Patients, Using the Missoula-Vitas Quality of Life Index: A Multicenter Study. Medicine and Pharmacy Reports, 92, 374-381. https://doi.org/10.15386/mpr-1320
United Nations (2020) The 2019 Revision of World Population Prospects. United Nations Department of Economic and Social Affairs of the United Nations Secretariat. https://population.un.org/wpp
Brar, A. and Markell, M. (2019) Impact of Gender and Gender Disparities in Patients with Kidney Disease. Current Opinion in Nephrology and Hypertension, 28, 178-182. https://doi.org/10.1097/MNH.0000000000000482
Erez, G., Selman, L. and Murtagh, F.E. (2016) Measuring Health-Related Quality of Life in Patients with Conservatively Managed Stage 5 Chronic Kidney Disease: Limitations of the Medical Outcomes Study Short Form 36: SF-36. Quality of Life Research. International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 25, 2799-2809. https://doi.org/10.1007/s11136-016-1313-7
Tripathy, S., Cai, X., Adhikari, A., Kershaw, K., Peralta, C.A., Kramer, H., Jacorbs, D.R., Gutierrez, O.M., Carnethon, M.R. and Isakova, T. (2020) Association of Educational Attainment with Incidence of CKD in Young Adults. Kidney International Reports, 5, 2256-2263. https://doi.org/10.1016/j.ekir.2020.09.015
Tannor, E., Archer, E., Kapembwa, K., van Schalkwyk, S.C. and Davids, M.R. (2017) Quality of Life in Patients on Chronic Dialysis in South Africa: A Comparative Mixed Method Study. Biomed Central Nephrology, 18, Article No. 4. https://doi.org/10.1186/s12882-016-0425-1
Mahato, S.K.S., Apidechkul, T., Sriwongpan, P., Hada, R., Sharma, G.N., Nayak, S.K. and Mahato, R.K. (2020) Factors Associated with Quality of Life among Chronic Kidney Disease Patients in Nepal: A Cross-Sectional Study. Health and Quality of Life Outcomes, 18, Article No. 207. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325283 https://doi.org/10.1186/s12955-020-01458-1
Aghoja, O.C., Akonoghrere, R.O., Odili, V.U. and Ajagbe, O. (2020) Quality of Life of Patients with Chronic Kidney Disease in Two Health Facilities in Delta State, Nigeria. Tropical Journal of Pharmaceutical Research, 19, 1759-1765. https://doi.org/10.4314/tjpr.v19i8.27
Dabrowska-Bender, M., Dykowska, G., Zuk, W., Milewska, M. and Staniszewska, A. (2018) The Impact on Quality of Life of Dialysis Patients with Renal Insufficiency. Patient Preference and Adherence, 12, 577-583. https://doi.org/10.2147/PPA.S156356
Adasi, G.S. (2020) Gender Differences in Stressors and Coping Strategies among Teacher Education Students at University of Ghana. Journal of Education and Learning, 9, 123-133. https://doi.org/10.5539/jel.v9n2p123
Al-Shehhi, M.S.M. and Shahin, F.A.A.E.S. (2016) Factors Affecting Quality of Life in Patients with End-Stage of Renal Disease on Haemodialysis, Ras Al Khaimah-United Arab Emirates. Journal of Health, Medicine and Nursing, 26, 220-238.
Pei, M., Aguiar, R., Pagels, A.A., Heimbürger, O., Stenvinkel, P., Bárány, P., Medin, C., Jacobson, C.H., Hylander, B., Lindholm, B. and Qureshi, A.R. (2019) Health-Related Quality of Life as Predictor of Mortality in End-Stage Renal Disease Patients: An Observational Study. Biomed Central Journal of Nephrology, 20, Article No. 144. https://doi.org/10.1186/s12882-019-1318-x
Kirkeskov, L., Carlsen, R.K., Lund, T. and Buss, N.H. (2021) Employment of Patients with Kidney Failure Treated with Dialysis or Kidney Transplantation—A Systematic Review and Meta-Analysis. Biomed Central Nephrology, 22, Article No. 348. https://doi.org/10.1186/s12882-021-02552-2
Nakayama, M., Ishida, M., Ogihara, M., Hanaoka, K., Tamura, M., Kanai, H., Tonozuka, Y. and Marshall, M.R. (2015) Social Functioning and Socioeconomic Changes after Introduction of Regular Dialysis Treatment and Impact of Dialysis Modality: A Multi-Centre Survey of Japanese Patients. Nephrology, 20, 523-530. https://doi.org/10.1111/nep.12482
Ranabhat, K., Khanal, P., Mishra, S.R., Khanal, A., Tripathi, S. and Sigdel, M.R. (2020) Health Related Quality of Life among Haemodialysis and Kidney Transplant Recipients from Nepal: A Cross Sectional Study Using WHOQOL-BREF. Biomed Central Journal of Nephrology, 21, Article No. 433. https://doi.org/10.1186/s12882-020-02085-0
van Haalen, H., Jackson, J., Spinowitz, B., Milligan, G. and Moon, R. (2020) Impact of Chronic Kidney Disease and Anaemia on Health-Related Quality of Life and Work Productivity: Analysis of Multinational Real-World Data. Biomed Central Nephrology, 21, Article No. 88. https://doi.org/10.1186/s12882-020-01746-4
Li, Y., Shi, H., Wang, W.M., Peng, A., Jiang, G.R., Zhang, J.Y., Ni, Z.H., He, L.Q., Niu, J.Y., Wang, N.S., Mei, C.L., Xu, X.D., Guo, Z.Y., Yuan, W.J., Yan, H.D., Deng, Y.Y., Yu, C., Cen, J., Zhang, Y. and Chen, N. (2016) Prevalence, Awareness, and Treatment of Anemia in Chinese Patients with Nondialysis Chronic Kidney Disease: First Multicenter, Cross-Sectional Study. Medicine (Baltimore), 95, e3872. https://doi.org/10.1097/MD.0000000000003872
Ganz, T. and Nemeth, E. (2016) Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Seminars in Nephrology, 36, 87-93. https://doi.org/10.1016/j.semnephrol.2016.02.001
Chen, S.S., Al Mawed, S. and Unruh, M. (2016) Health-Related Quality of Life in End-Stage Renal Disease Patients: How Often Should We Ask and What Do We Do with the Answer? Blood Purification, 41, 218-224. https://doi.org/10.1159/000441462