Approach to Acute Kidney Injury: Diagnosis and Management
- 1 Affiliated with South Carolina Clinical Research LLC, Orangeburg, SC, USA
Abstract
Acute kidney injury is a critical but commonly occurring medical condition that presents with a sudden decline in kidney function. This comprehensive review article provides an in-depth examination of the risk elements, etiology, diagnosis, management, and preventive approach of AKI. The causes that contribute to the development of AKI include prerenal, intrinsic renal, and postrenal. The diagnostic approach to AKI includes clinical, laboratory, and imaging studies to evaluate the root cause analysis and to find out the severity of kidney injury. Timely and accurate diagnosis is crucial for initiating appropriate management strategies. The treatment strategies may include fluid and electrolyte management, medication adjustments, nutritional support, and renal replacement therapy. The prospect of recovery diverges as it relies on the individual factors, reasons, and gravity of the condition. This review highlights the importance of raising awareness among healthcare professionals and the public about AKI, early recognition of risk factors, and prompt management. Further research is needed to explore novel therapeutic approaches and refine existing management guidelines for this critical condition.
- Thomas, M.E., et al. (2015) The Definition of Acute Kidney Injury and Its Use in Practice. Kidney International, 87, 62-73. https://doi.org/10.1038/ki.2014.328
- Jacob, J., et al. (2020) Acute Kidney Injury. Primary Care, 47, 571-584. https://doi.org/10.1016/j.pop.2020.08.008
- Siemens Healthcare Diagnostics Inc. (2017) Statistics and Facts: Acute Kidney Injury (AKI). https://cdn0.scrvt.com/39b415fb07de4d9656c7b516d8e2d907/1800000004901183/e0fb8f113a54/Kidney_Disease_Infographics_2017FINAL_1800000004901183.PDF
- CDC (2018, March 16) Trends in Hospitalizations for Acute Kidney Injury-United States, 2000-2014. Centers for Disease Control and Prevention, Atlanta. https://www.cdc.gov/mmwr/volumes/67/wr/mm6710a2.htm
- Beker, B.M., et al. (2018) Novel Acute Kidney Injury Biomarkers: Their Characteristics, Utility, and Concerns. International Urology and Nephrology, 50, 705-713. https://doi.org/10.1007/s11255-017-1781-x
- Moore, P.K., et al. (2018) Management of Acute Kidney Injury: Core Curriculum 2018. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 72, 136-148. https://doi.org/10.1053/j.ajkd.2017.11.021
- Mercado, M.G., et al. (2019) Acute Kidney Injury: Diagnosis and Management. American Family Physician, 100, 687-694.
- Macedo, E. and Mehta, R.L. (2018) Clinical Approach to the Diagnosis of Acute Kidney Injury. In: Gilbert, S.J. and Weiner, D.E., Eds., National Kidney Foundation’s Primer on Kidney Diseases, Elsevier, Amsterdam, 300-310.e2. https://doi.org/10.1016/B978-0-323-47794-9.00031-7
- Levey, A.S. and James, M.T. (2017) Acute Kidney Injury. Annals of Internal Medicine, 167, ITC66-ITC80. https://doi.org/10.7326/AITC201711070
- Rewa, O. and Bagshaw, S.M. (2014) Acute Kidney Injury-Epidemiology, Outcomes and Economics. Nature Reviews Nephrology, 10, 193-207. https://doi.org/10.1038/nrneph.2013.282
- Goyal, A., et al. (2023) Acute Kidney Injury. StatPearls Publishing, Treasure Island.
- KDIGO (2012) KDIGO 2012 Clinical Practice Guideline Acute Kidney Injury. https://kdigo.org/guidelines/acute-kidney-injury
- Muriithi, A.K., et al. (2015) Clinical Characteristics, Causes and Outcomes of Acute Interstitial Nephritis in the Elderly. Kidney International, 87, 458-464. https://doi.org/10.1038/ki.2014.294
- National Kidney Foundation (2023) Acute Kidney Injury (AKI). https://www.kidney.org/atoz/content/AcuteKidneyInjury