Prevalence of Peripheral Artery Disease and Its Associated Factors in Patients with Predialysis Chronic Kidney Disease in Ouagadougou — Oak Academic Publishing
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Prevalence of Peripheral Artery Disease and Its Associated Factors in Patients with Predialysis Chronic Kidney Disease in Ouagadougou
Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
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Department of Nephrology and Hemodialysis, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
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Department of Nephrology, University Hospital of Brazzaville, Brazzaville, Congo
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Bamako University of Sciences and Technology, Bamako, Mali
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Gamal Abdoul Nasser University, Conakry, Guinea
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Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
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Department of Nephrology and Hemodialysis, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
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Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
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Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
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Department of Nephrology and Hemodialysis, University Hospital of Tengandogo, Ouagadougou, Burkina Faso
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Department of Nephrology and Hemodialysis, University Hospital of Point G, Bamako, Mali
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Department of Nephrology and Hemodialysis, University Hospital of Donka, Conakry, Guinea
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Department of Nephrology and Hemodialysis, University Hospital Sourou Sanou, Bobo Dioulasso, Burkina Faso
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Department of Cardiology, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
1 Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
2 Department of Nephrology and Hemodialysis, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
3 Department of Nephrology, University Hospital of Brazzaville, Brazzaville, Congo
4 Bamako University of Sciences and Technology, Bamako, Mali
5 Gamal Abdoul Nasser University, Conakry, Guinea
6 Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
7 Department of Nephrology and Hemodialysis, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
8 Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
9 Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
10 Department of Nephrology and Hemodialysis, University Hospital of Tengandogo, Ouagadougou, Burkina Faso
11 Department of Nephrology and Hemodialysis, University Hospital of Point G, Bamako, Mali
12 Department of Nephrology and Hemodialysis, University Hospital of Donka, Conakry, Guinea
13 Department of Nephrology and Hemodialysis, University Hospital Sourou Sanou, Bobo Dioulasso, Burkina Faso
14 Department of Cardiology, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso
Background: Peripheral artery disease (PAD) is associated with increased cardiovascular and overall morbidity and mortality in patients with predialysis chronic kidney disease (CKD). In sub-Saharan Africa, data on PAD in this population are scarce. Objectives: To evaluate the prevalence of PAD and identify associated factors in a predialysis CKD patient population. Patients and Meth ods : This cross-sectional study was conducted from June 1 to August 31, 2019, in Ouagadougou, Burkina Faso. Patients aged at least 18 years, who had been followed-up for at least three months for CKD, and who were not undergoing hemodialysis were included. PAD was defined as an ankle-brachial index (ABI) value of <0.9. Results : A total of 138 patients with a mean age of 56.76 years ± 15.13 years were included in the study. The sex-ratio was 1.06. The average glomerular filtration rate (GFR) was 37.50 mL/min/1.73m 2 ± 29.45 mL/min/1.73m 2 , and 81.16% of patients had stage 5 CKD. PAD was present in 77 patients (55.8%). Its prevalence increased overall with the decline of renal function. In the univariate analysis, the following variables were found to be statistically correlated with PAD: history of dyslipidemia (OR = 1.89; 95% CI: [1.6 - 2.2]), diabetic nephropathy (OR = 1.50; 95% CI: [1.11 - 2.03]), autosomal dominant polycystic kidney disease (OR = 0.24; 95% CI: [0.04 - 1.04]), pulse pressure (PP) > 60 mmHg (OR = 2.08; 95% CI: [1.05 - 4.18]), hyperuricemia (OR = 2.97; 95% CI: [1.41 - 6.36]), high triglyceride levels (OR = 7.36; 95% CI: [1.02 - 92.6]), and severe anemia (OR = 2.16; 95% CI: [1.7 - 2.6]). PP > 60 mmHg and hyperuricemia were independently associated with PAD, with odds ratios of 2.11 (95% CI: [1.05 - 4.24]) and 2.8 (95% CI: [1.38 - 5.66]), respectively, after adjusting for sex, age, and CKD duration. Conclusion: The prevalence of PAD is high in patients with predialysis CKD and generally increases with declining renal function.
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