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Renal Transplant in a Hypersensitive Patient: A Case Report
Nephrology Department, Clínica Delgado, Lima, Peru
School of Medicine, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
General Surgery Department, Clínica Delgado, Lima, Peru
Interventional Radiology Department, Clínica Delgado, Lima, Peru
School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru
School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru
Urology Department, Clínica Delgado, Lima, Peru
- 1 Nephrology Department, Clínica Delgado, Lima, Peru
- 2 School of Medicine, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
- 3 General Surgery Department, Clínica Delgado, Lima, Peru
- 4 Interventional Radiology Department, Clínica Delgado, Lima, Peru
- 5 School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru
- 6 School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru
- 7 Urology Department, Clínica Delgado, Lima, Peru
Open Journal of Nephrology·Volume 15 (2025)·Pages 506–512·Published 21 October 2025·DOI10.4236/ojneph.2025.154047
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Abstract
In hypersensitized patients, Kidney Transplant (KT) rates are low due to the risk of organ loss due to rejection. Desensitization (DS) protocols have been developed to prevent rejection, increasing their success. We present the case of a 65-year-old female patient with Chronic Kidney Disease (CKD) associated with Hypertensive Nephroangiosclerosis (HNA) on Hemodialysis (HD). She was documented to have hypersensitization against Human Leukocyte Antigen (HLA), presenting Donor-Specific Antibodies (DSA) detected by solid-phase techniques, making her a high-immunological risk patient. With a suitable living donor available, a desensitization protocol was initiated. DS treatment consisted of plasmapheresis, Intravenous Immunoglobulin (IVIG) and Rituximab, with a successful KT result.
KeywordsHLA HypersensitivityDesensitizationRenal Transplants
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