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A Case of Cytomegalovirus-Induced Arthritis after Lymphocyte-Depleting Therapy for Kidney Allograft Rejection
Health Science Center Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA
Health Science Center Division of Renal Diseases and Hypertension, Transplant Center, University of Colorado Denver, Aurora, USA
- 1 Health Science Center Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA
- 2 Health Science Center Division of Renal Diseases and Hypertension, Transplant Center, University of Colorado Denver, Aurora, USA
Open Journal of Nephrology·Volume 02 (2012)·Pages 1–4·Published 28 March 2012·DOI10.4236/ojneph.2012.21001
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Abstract
Cytomegalovirus viremia and tissue-invasive disease are common after kidney transplantation. Chemoprophylaxis has made substantial improvement in this clinical problem. Here we report a 29-year-old woman who had kidney allograft rejection and received lymphocyte-depleting therapy. She presented with a new oligo-arthritis that led to 2 successive arthrocenteses. The etiology of the inflammation could not be determined initially. On the second arthrocentesis, a synovial fluid cytomegalovirus polymerase chain reaction test was positive. The patient responded to treatment with valganciclovir, had negative follow-up serum cytomegalovirus polymerase chain reaction tests, and experienced resolution of her joint inflammation. We review briefly the data for cytomegalovirus chemoprophylaxis, preemptive screening, and treatment recommendations.
KeywordsCytomegalovirus (Mesh)Arthritis (Mesh)Kidney Transplantation (Mesh)Immunosuppression (Mesh)Chemoprevention (Mesh)Valganciclovir (Mesh)
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