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Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria

¹ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
² Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
³ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
⁴ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
⁵ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
⁶ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
⁷ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India
⁸ Intrenal & Pulmonary Medicine, Sheri Kashmir Institute of Medicine, Srinagar, India

Open Journal of Nephrology·Volume 03 (2013)·Pages 101–103·Published 4 June 2013·DOI10.4236/ojneph.2013.32017

Abstract

Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count (eosinophilia) along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1-4], with no obvious cause for eosinophilia. The onset of symptoms is insidious in most of the cases and eosinophilia is detected incidentally. However, in others, the initial manifestations are severe and life-threatening due to the rapid evolution of cardiac or neurologic complications [5]. Renal involvement is rarely reported [6] in IHES. Herein we reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy.

KeywordsIdiopathic Hypereosinophilic SyndromeEosinophiliaRenal InvolvementNephrotic Syndrome

P. F. Weller and G. J. Bubley, “The Idiopathic Hypereosinophilic Syndrome,” Blood, Vol. 83, No. 10, 1994, p. 2759.
F. Roufosse, E. Cogan and M. Goldman, “Recent Advances in Pathogenesis and Management of Hypereosinophilic Syndromes,” Allergy, Vol. 59, No. 7, 2004, pp. 673-689. doi:10.1111/j.1398-9995.2004.00465.x
A. D. Klion, B. S. Bochner, G. J. Gleich, et al., “Approaches to the Treatment of Hypereosinophilic Syndromes: A Workshop Summary Report,” Journal of Allergy and Clinical Immunology, Vol. 117, No. 6, 2006, pp. 1292-1302. doi:10.1016/j.jaci.2006.02.042
J. Sheikh and P. F. Weller, “Clinical Overview of Hypereosinophilic Syndromes,” Immunology and Allergy Clinics of North America, Vol. 27, No. 3, 2007, pp. 333355. doi:10.1016/j.iac.2007.07.007
V. Ambarus and A. Cosovanu, “The Evolutionary Characteristics of the Hypereosinophilic Syndrome,” Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din Lasi’S, Vol. 102, No. 1-2, 1998, pp. 69-75.
J. L. Motellon, C. Bernis, A. Garcia-Sanchez, E. Gruss and J. A. Traver, “Renal Involvement in the Hyper-Eosinophilic Syndrome,” Nephrology Dialysis Transplantation, Vol. 10, No. 3, 1995, pp. 401-403.
A. S. Fauci, J. B. Harley, W. C. Roberts, V. J. Ferrans, H. R. Gralmick and B. H. Bhorson, “The Idiopathic Hypereosinophilic Syndrome: Clinical, Pathophy-Siologic and Therapeutic Considerations,” Annals of Internal Medicine, Vol. 97, No. 1, 1982, pp. 78-92. doi:10.7326/0003-4819-97-1-78
I. Navarro, J. Torras, M. Gomà, J. M. Cruzado and J. M. Grinyó, “Renal Involvement as the First Manifestation of Hypereosinophilic Syndrome,” Clinical Kidney Journal, Vol. 2, No. 5, 2009, pp. 379-381.
C. J. Spry, J. Davies, P. C. Tai, E. G. Oslen, C. M. Oakley and J. F. Goodwin, “Clinical Features of Fifteen Patients with the Hypereosinophilic Syndrome,” Journal of Nuclear Medicine, Vol. 205, No. 52, 1983, pp. 1-2.
F. Bulucu, C. Can, V. Inal, Y. Baykal and S. Erikci, “Renal Involvement in a Patient with Idiopathic Hypereosinophilic Syndrome,” Clinical Nephrology, Vol. 57, No. 2, 2002, pp. 171-172.
M. Frigui, M. B. Hmida, M. Jallouli, M. Kechaou, F. Frikha and Z. Bahloul, “Membranousglomerulopathy Associated with Idiopathic Hypereosinophilic Syndrome,” Saudi Journal of Kidney Diseases and Transplantation, Vol. 21, No. 2, 2010, pp. 320-322.
Y. J. Choi, J. D. Lee, K. H. Yang, B. K. Kim, B. K. Bang and S. I. Shim, “Immunotactoidglomerulopathy Associated with Idiopathic Hypereosinophilic Syndrome,” American Journal of Nephrology, Vol. 18, 1998, pp. 337-343. doi:10.1159/000013362

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Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria

Abstract

References (22)