Based on neuroscientific facts and cosmological considerations, the hypothesis is presented here that just as the guided complexity of matter and energy in the unique space-time of each human brain generates the host’s Soul, the infinite complexity of the Multiverse, a more likely embodiment of the allness of existence than a single Universe, must also have a Soul. It is appreciated that this hypothesized Soul of Multiverse, imagined as majestically as obscurely in some ancient religious texts, is currently outside of the realm of science. Yet, this paper argues that the intellectual and technological advances of the 21 st century created favorable conditions for starting to address the nature of Soul across human and cosmic scales with the approach of cosmological neuroscience. This interdisciplinary field aims to examine the nervous system in the context of cosmic laws, including the laws that made life on Earth possible and let it evolve to generate the nervous system and its increasingly more sophisticated forms culminating into the appearance of human Soul and its noospheric expansion with purpose and potential to transcend. A human-specific prefrontal cortical supercircuitry termed Self-Ken, with domains Conscience, Mission, Will and Identity, is proposed for the neural center of the individual human Soul. The design of a globally applicable Noospheric Creativity Monitor is introduced to initiate the examination of Soul at its individual and global levels. Possible experimental astronomical and broadened cosmological studies are mentioned to evaluate the discussed hypothesis.
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