Extending the Behrens-Fisher Problem to Testing Equality of Slopes in Linear Regression: The Bayesian Approach
- 1 Department of Cell Biology, National Biotechnology Center, Research Centre, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- 2 Department of Cell Biology, National Biotechnology Center, Research Centre, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Abstract
Testing the equality of means of two normally distributed random variables when their variances are unequal is known in the statistical literature as the “Behrens-Fisher problem”. It is well-known that the posterior distributions of the parameters of interest are the primitive of Bayesian statistical inference. For routine implementation of statistical procedures based on posterior distributions, simple and efficient approaches are required. Since the computation of the exact posterior distribution of the Behrens-Fisher problem is obtained using numerical integration, several approximations are discussed and compared. Tests and Bayesian Highest-Posterior Density (H.P.D) intervals based upon these approximations are discussed. We extend the proposed approximations to test of parallelism in simple linear regression models.
- Jeffreys, B. (1940) Note on the Behrens-Fisher Formula. Annals of Eugenics, 10, 48-51. https://doi.org/10.1111/j.1469-1809.1940.tb02236.x
- Behrens, W.V. (1929) Ein Beitragzur Fehlerberechunung bei Weniger Beoachtungen. Landw. Jb., 68, 807-837.
- Fisher, R.A. (1939) The Comparison of Samples with Possibly Unequal Variances. Annals of Eugenics, 9, 174-180. https://doi.org/10.1111/j.1469-1809.1939.tb02205.x
- Reilly, P.M. (1976) The Numerical Computation of Posterior Distributions. Applied Statistics, 25, 201-209. https://doi.org/10.2307/2347227
- Naylor, J.C. and Smith, A.F.M. (1982) Applications of a Method for the Efficient Computation of Posterior Distributions. Applied Statistics, 31, 214-225. https://doi.org/10.2307/2347995
- Robert, C. and Casella, G. (2009) Introducing Monte Carlo Methods with R. Springer, New York.
- Lee, P.M. (1989) Bayesian Statistics: An Introduction. Oxford University Press.
- Box, G.E.P. and Taio, G.C. (1973) Bayesian Inference in Statistical Analysis. Addison-Wesley Publishing Company, Inc., Reading, Mass.
- Barnard, G.A. (1984) Comparing the Means of Two Independent Samples. Applied Statistics, 33, 266-271. https://doi.org/10.2307/2347702
- Patil, V.H. (1964) The Behrens-Fisher Problem and Its Bayesian Solution. Journal of the Indian Society for Probability and Statistics, 2, 21-31.
- Feller, W. (1971) An Introduction to Probability Theory and Its Applications. 2nd Edition, John Wiley & Sons, Inc., New York.
- Barndorff-Nielson, O. and Cox, D.R. (1979) Edgeworth and Saddle-Point Approximations with Statistical Applications. Journal of the Royal Statistical Society: Series B, 41, 279, 312.
- Edgeworth, F.Y. (1896) The Asymmetrical Probability Curve. Philosophical Magazine, 5th Series, 41, 90-99.
- Edgeworth, F.Y. (1907) On the Representation of Statistical Frequency by Series. Journal of the Royal Statistical Society: Series A, 70, 102-106. https://doi.org/10.2307/2339504
- Klein, M.E., Dabbs, D.J., Shuai, Y., Brufsky, A.M., Jankowitz, R., Puhalla, S.L., et al. (2013) Prediction of the Oncotype DX Recurrence Score: Use of Pathology-Generated Equations Derived by Linear Regression Analysis. Modern Pathology, 26, 658-664.
- Welch, B.L. (1937) The Significance of the Difference between Two Means when the Population Variances Are Unequal. Biometrika, 34, 28-35.