Growth Hormone Releasing Hormone Receptors Antagonists and Cancers: Do GHRH-R Antagonists Play a Role in the Management of Prostate Cancer? — Oak Academic Publishing
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Growth Hormone Releasing Hormone Receptors Antagonists and Cancers: Do GHRH-R Antagonists Play a Role in the Management of Prostate Cancer?
Pharmacology Department of Gannan Medical University, Ganzhou, China
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Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Ganzhou, China
,
Urology Department of the First Affiliate Hospital of Gannan Medical University, Ganzhou, China
,
Urology Department of the First Affiliate Hospital of Gannan Medical University, Ganzhou, China
,
Pharmacology Department of Gannan Medical University, Ganzhou, China
1 Pharmacology Department of Gannan Medical University, Ganzhou, China
2 Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Ganzhou, China
3 Urology Department of the First Affiliate Hospital of Gannan Medical University, Ganzhou, China
4 Urology Department of the First Affiliate Hospital of Gannan Medical University, Ganzhou, China
5 Pharmacology Department of Gannan Medical University, Ganzhou, China
Growth hormone-releasing hormone (GHRH) and its receptors have been implicated in the progression of various tumors such as those of the prostate. Treatment modalities for prostate cancer in a localized stage or when it is still castration-sensitive yield good results in most patients. However, such treatments are only palliative in the advanced stage. Therefore, new therapeutic targets like growth hormone-releasing hormone receptor (GHRH-R) and its splice variants should be found in order to get effective treatments for more aggressive stages in prostate cancer. This review talks about the GHRH-R and its splice variants, the signaling pathways induced by GHRH to produce cancer, the structure activity relationship of GHRH-R antagonists and the resume of some in vitro and in vivo studies on the role of GHRH-R antagonists in the treatment of prostate cancer.
KeywordsGHRHReceptorsAntagonistsProstateCancer
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