Introduction: Prostate cancer is the leading urological cancer. It is the most common cancer in men over 50. Objective: To determine the epidemiological, diagnostic and therapeutic characteristics of prostate cancer in hospitals in the Thiès region. Patients and Methods: We conducted a descriptive study from January 1 st , 2015 to December 31 st , 2020. We included all cases of primary prostate cancer confirmed on histology. Results: We collected data on 318 cases of primary prostate cancer during the study period. Mean patient age was 72.7 years (Range: 49; 94 years). Family history of prostate cancer was found in 22 patients (6.91%). The average consultation time was 18.6 months. The circumstances of discovery were dominated by obstructive voiding disorders (97.16%). Digital Rectal examination was suggestive in 55.40% of patients. PSA level was above 20 ng/ml in 76.7% of patients. Prostatic adenocarcinoma was the only histological type (100%). Localized cancer represented 7.2% and locally advanced cancer occurred in 36.5% of cases, while metastatic cancer accounted for 56.3%. Radical prostatectomy was performed in 3.18% of cases. Mortality rate was estimated at 8.50% after 1 year. Conclusion: Prostate cancer is the leading urological cancer in the Thies region. It is characterized by the predominance of locally advanced and metastatic forms.
Siegel, R.L., Miller, K.D. and Jema, L.A. (2019) Cancer Statistics, 2019. CA: A Cancer Journal for Clinicians, 69, 7-34. https://doi.org/10.3322/caac.21551
Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., Negri, E., et al. (2020) European Cancer Mortality Predictions for the Year 2020 with a Focus on Prostate Cancer. Annals of Oncology, 31, 650-658. https://doi.org/10.1016/j.annonc.2020.02.009
Gueye, S.J.M., Labou, I., Niang, L., Kane, R. and Ndoye, M. (2004) Profil Clinique Du Cancer De La Prostate Au Sénégal. African Journal of Urology, 10, 203-207.
Diallo, Y., Kouka, S.C., Jalloh, M., et al. (2019) Metastatic Prostate Cancer: Clinical Aspects and Therapeutic Management in the Region of Thies, Senegal. Medical & Surgical Urology, 8, 224.
Gueye, S. (2014) Advanced Prostate Cancer in Senegal. Clinical Aspects at the General Hospital of Grand Yoff. Progrès en Urologie, 24, 271-275. https://doi.org/10.1016/j.purol.2013.08.317
Jalloh, M., Niang, L., Ndoye, M., Labou, I. and Gueye, S.M. (2013) Prostate Cancer in Sub Saharan Africa. Journal of Nephrology and Urology Research, 1, 15-20. https://doi.org/10.12970/2310-984X.2013.01.01.4
Cassell, A., Yunusa, B., Jalloh, M., et al. (2019) A Review of Localized Prostate Cancer: An African Perspective. World Journal of Oncology, 10, 162-168. https://doi.org/10.14740/wjon1221
Osegbe, D.N. (1997) Prostate Cancer in Nigerians: Facts and Non-Facts. Journal of Urology, 157, 1340-1343. https://doi.org/10.1016/S0022-5347(01)64966-8
Horwich, A., Parker, C., De Reijke, T., et al. (2013) Prostate Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Annals of Oncology, 24, Vi106-Vi114. https://doi.org/10.1093/annonc/mdt208
Persaud, S., Goetz, L. and Burnett, A.L. (2017) Active Surveillance for Prostate Cancer: Is It Ready for Primetime in the Caribbean? African Journal of Urology, 23, 89-93. https://doi.org/10.1016/j.afju.2016.07.003
Kyei, M.Y., Mensah, E.J., Gepi-Attee, S., Kwami, D., Ampadu, K., Asante, E., Klufio, G.O., et al. (2013) Outcomes after Radical Prostatectomy in Ghanaians: A Surgeon’s Early Experience. ISRN Urology, 2013, Article ID: 832496. https://doi.org/10.1155/2013/832496
Ntama, A., Owon’Abessolo, P., Sango, A.J.F., Titti Mboumteke, J.G.F., Esson Mapoko, B.S., et al. (2023) épidémiologie et Diagnostic Du Cancer De La Prostate Dans La Ville De Douala (Cameroun). Health Sciences and Diseases, 24, 33-38. https://doi.org/10.4236/oju.2014.41002
Kabore, F.A., Zango, B., Kambou, T., Ouedraogo, A.S., Bam-Bara, A., Yameogo, C., et al. (2014) Prostate Cancer Disease Characteristics at the Time of Diagnosis and Initial Treatment Offered in a Tertiary Hospital at Ouagadougou (Burkina Faso). Open Journal of Urology, 4, 7-12.
Tengue, K., Kpatcha, T.M., Botcho, G., Leloua, E., Amavi, A.K., Sikpa, K., et al. (2016) Profil Epidemiologique, Diagnostique, Therapeutique et Evolutif Du Cancer De La Prostate Au Togo. African Journal of Urology, 22, 76-82. https://doi.org/10.1016/j.afju.2015.06.006
Ndiaye, M., Sow, O., Thiam, A., Sarr, A., Gaye, O. and Sine, B. (2020) Le Cancer De La Prostate Au Centre Hospitalier Universitaire Aristide Le Dantec De Dakar: Aspects épidémiologiques Sur Les Cinq Derniéres Années. Annales Africaines de Médecine, 14, e4004-e4009. https://anafrimed.net/cancer-de-la-prostate-au-centre-hospitalier-universitaire-aristidie-le-dantec-de-dakar-aspects-epidemiologiques-sur-les-cinq-dernieres-annees-prostate-cancer-in-aristide-le-dantec-hospital-of-dakar/
Xu, J. (2000) Combined Analysis of Hereditary Prostate Cancer Linkage to 1q24-25: Results from 772 Hereditary Prostate Cancer Families from the International Consortium for Prostate Cancer Genetics. The American Journal of Human Genetics, 66, 945-945. https://doi.org/10.1086/302807
Loeb, S. and Catalonia, W.J. (2009) What Is the Role of Digital Rectal Examination in Men Undergoing Serial Serum PSA Screening? Levels? Nature Clinical Practice Urology, 6, 68-69. https://doi.org/10.1038/ncpuro1294
Niang, L., Kouka, C.N., Jalloh, M. and Gueye, S.M. (2011) Screening for Prostate Cancer by Digital Rectal Examination and PSA Determination in Senegal. ISRN Oncology, 2011, Article ID: 943704. https://doi.org/10.5402/2011/943704
Descotes, J.L. (2019) Diagnosis of Prostate Cancer. Asian Journal of Urology, 6, 129-136. https://doi.org/10.1016/j.ajur.2018.11.007
Oranusi, C.K., Mbieri, U.T., Oranusi, I.O. and Nwofor, A.M. (2012) Prostate Cancer Awareness and Screening among Male Public Servants in Anambra State, Nigeria. African Journal of Urology, 18, 72-74. https://doi.org/10.1016/j.afju.2012.04.016
Nakandi, H., Kirabo, M., Semugabo, C., Kittengo, A., Ki-Tayimbwa, P., Kalungi, S. and Maena, J. (2013) Knowledge, Attitudes and Practices of Ugandan Men Regarding Prostate Cancer. African Journal of Urology, 19, 165-170. https://doi.org/10.1016/j.afju.2013.08.001
Fall, B., Sarr, A., Ouedraogo, B., Sow, Y., Thiam, A., Diallo, Y., et al. (2015) Detection Precoce Du Cancer De La Prostate Chez Des Apparentes De Premier Degre Au Senegal. African Journal of Urology, 21, 225-229. https://doi.org/10.1016/j.afju.2015.08.002
Cussenot, O. and Teillac, P. (1999) Cancer de la Prostate. Path Sciences, Paris, 616.
Ndoye, M., Niang, L., Gandaho, I.K., Jalloh, M., Labou, I. and Gueye, S.M. (2014) Cancer Avancé De La Prostate Au Sénégal. Aspects Diagnostiques á L’hôpital De Grand Yoff. Progrés en Urologie, 24, 271-275. https://doi.org/10.1016/j.purol.2013.08.317
Eifler, J.B., Feng, Z., Brian, M., Partin, M.T., Humphreys, E.B., Misop, H., et al. (2013) An Updated Prostate Cancer Staging Nomogram (Partin Tables) Based on Cases from 2006 to 2011. BJU International, 111, 22-29. https://doi.org/10.1111/j.1464-410X.2012.11324.x
Rozet, F., Hennequin, C., Beauval, J.B., Beuzeboc, P., Cormier, L., Fromont-Hankard, G., et al. (2018) French CcAFU Guidelines—Update 2018-2020: Prostate Cancer. Progrès en Urologie, 28, R81-R132. https://doi.org/10.1016/j.purol.2019.01.007
Hövels, A.M., Heesakkers, R.A., Adang, E.M., Jager, G.J., Strum, S., Hoogeveen, Y.L., et al. (2008) The Diagnostic Accuracy of CT and MRI in the Staging of Pelvic Lymph Nodes in Patients with Prostate Cancer: A Meta-Analysis. Clinical Radiology, 63, 387-395. https://doi.org/10.1016/j.crad.2007.05.022
Gandaglia, G., Ploussard, G., Valerio, M., Mattei, A., Fiori, C., Fossati, N., et al. (2019) A Novel Nomogram to Identify Candidates for Extended Pelvic Lymph Node Dissection among Patients with Clinically Localized Prostate Cancer Diagnosed with Magnetic Resonance Imaging-Targeted and Systematic Biopsies. European Urology, 75, 506-514. https://doi.org/10.1016/j.eururo.2018.10.012
Lecouvet, F.E., Simon, M., Tombal, B., Jamart, J., Vande Berg, B.C. and Simoni, P. (2010) Whole-Body MRI (WB-MRI) versus Axial Skeleton MRI (AS-MRI) to Detect and Measure Bone Metastases in Prostate. European Radiology, 20, 2973-2982. https://doi.org/10.1007/s00330-010-1879-3
Gutzeit, A., Doert, A., Froehlich, J.M., Eckhardt, B.P., Meili, A., Scherr, P., et al. (2010) Comparison of Diffusion-Weighted Whole Body MRI and Skeletal Scintigraphy for the Detection of Bone Metastases in Patients with Prostate or Breast Carcinoma. Skeletal Radiology, 39, 333-343. https://doi.org/10.1007/s00256-009-0789-4
Ruenes, A. and Gueye, S.M. (2008) Teaching Radical Prostatectomy in Sub-Saharan Africa. The Canadian Journal of Urology, 15, 3886-3889.
Babacar, S., Aissatou, B.N., Cyrille, Z.O., Amath, T., Alioune, S., Yaya, S., et al. (2018) Cancer de la Prostate Localisé à Haut Risque de Récidive: Résultats de la Prise Charge. African Journal of Urology, 24, 296-302. https://doi.org/10.1016/j.afju.2018.11.001
Niang, L., Ndoye, M., Ouattara, A., Jalloh, M., Labou, M., Thi-Am, I., Kouka, S.C., et al. (2013) Management of Prostate Cancer in Senegal: What Is Being Done? Progrès en Urologie, 23, 36-41. https://doi.org/10.1016/j.purol.2012.09.002
Heidenreich, A., Ohlmann, C.H. and Polyakov, S. (2007) Anatomical Extent of Pelvic Lymphadenectomy in Patients Undergoing Radical. European Urology, 52, 29-37. https://doi.org/10.1016/j.eururo.2007.04.020
Fall, B., Tengue, K., Sow, Y., Sarr, A., Ba, M. and Diagne, B.A. (2012) Place de la Pulpectomie Bilatérale Dans la Suppression Androgénique Pour Le Cancer de la Prostate. Progrès en Urologie, 22, 344-349. https://doi.org/10.1016/j.purol.2011.12.005