Socio-Demographic and Clinical Characteristics of Patients Presenting with Lower Urinary Tract Symptoms Secondary to BPH, in a Tertiary Hospital — Oak Academic Publishing
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Socio-Demographic and Clinical Characteristics of Patients Presenting with Lower Urinary Tract Symptoms Secondary to BPH, in a Tertiary Hospital
Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
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Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
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Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
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Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana
1 Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
2 Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
3 Department of Surgery, School of Medicine, University for Development Studies, Tamale, Ghana
4 Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana
Background : Benign prostatic hyperplasia (BPH) is the proliferation of the stromal and epithelial cells of the prostate gland, resulting in an increase in its size. This may result in obstruction of the lower urinary tract causing storage and voiding symptoms. Methods : This was a prospective cross-sectional study from August 2020 to July 2021, to evaluate the characteristic of patients presenting to the Tamale Teaching Hospital with lower urinary tract symptoms secondary to BPH. Results : The median age at presentation with LUTS secondary to BPH is 68.88 ± 11.10 years with an average prostate volume of 70 g. The average time of presentation to the hospital is 5 months, mostly with moderate to severe symptoms. Correlation between Prostate volume (PV) and age yielded a positive relationship; however, this was not statistically significant, (r = 0.028, p-value = 0.747). There was a significant positive relationship between PV and the IPSS score, (r = 0.334, p-value < 0.001). Conclusion : Our patients with symptomatic BPH present at age 60 years and above, with nearly all of them presenting with moderate to severe LUTS.
Lowsley, O.S. (1912) The Development of the Human Prostate Gland with Reference to the Development of Other Structures at the Neck of the Urinary Bladder. American Journal of Anatomy , 13, 299-349. https://doi.org/10.1002/aja.1000130303
Moore, K.L., Dalley, A.F. and Agur, A.M.R. (2013) Clinically Oriented Anatomy. 5th Edition, Lippincott Williams & Wilkins.
Roehrborn, C.G. (2008) Pathology of Benign Prostatic Hyperplasia. International Journal of Impotence Research , 20, S11-S18. https://doi.org/10.1038/ijir.2008.55
Roehrborn, C.G. (2005) Benign Prostatic Hyperplasia: An Overview. Reviews in Urology , 7, S3-S14.
Chokkalingam, A.P., Yeboah, E.D., DeMarzo, A., Netto, G., Yu, K., Biritwum, R.B., et al . (2011) Prevalence of BPH and Lower Urinary Tract Symptoms in West Africans. Prostate Cancer and Prostatic Diseases , 15, 170-176. https://doi.org/10.1038/pcan.2011.43
Lee, S.W.H., Chan, E.M.C. and Lai, Y.K. (2017) The Global Burden of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis. Scientific Reports , 7, Article No. 7984. https://doi.org/10.1038/s41598-017-06628-8
Yeboah, E. (2016) Prevalence of Benign Prostatic Hyperplasia and Prostate Cancer in Africans and Africans in the Diaspora. Journal of West African College of Surgeons , 6, 1-30.
Ghana Statistical Service (2012) 2010 Population and Housing Census; Summary Report of Final Results. Ghana Statistical Service, Accra.
Kenneth, A., Francis, A., Christian, G., Ferguson, L., Emmanuel, A., Benjamin, T., et al . (2016) Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia among Ghanaian Men: A Hospital-Based Cross-Sectional Prospective Study. International Journal of Research in Medical Sciences , 4, 3905-3911. https://doi.org/10.18203/2320-6012.ijrms20162906
Ojewola, R.W., Oridota, E.S., Balogun, O.S., Alabi, T.O., Ajayi, A.I., Olajide, T.A., et al . (2017) Prevalence of Clinical Benign Prostatic Hyperplasia Amongst Community-Dwelling Men in a South-Western Nigerian Rural Setting: A Cross-Sectional Study. African Journal of Urology , 23, 109-115. https://doi.org/10.1016/j.afju.2016.02.004
Zhang, J., Ma, M., Nan, X. and Sheng, B. (2016) Obesity Inversely Correlates with Prostate-Specific Antigen Levels in a Population with Normal Screening Results of Prostate Cancer in Northwestern China. Brazilian Journal of Medical and Biological Research , 49, e5272. https://doi.org/10.1590/1414-431x20165272
Seim, A., Hoyo, C., Østbye, T. and Vatten, L. (2005) The Prevalence and Correlates of Urinary Tract Symptoms in Norwegian Men: The HUNT Study. BJU International , 96, 88-92. https://doi.org/10.1111/j.1464-410x.2005.05573.x
Safarinejad, M.R. (2008) Prevalence of Benign Prostatic Hyperplasia in a Population-Based Study in Iranian Men 40 Years Old or Older. International Urology and Nephrology , 40, 921-931. https://doi.org/10.1007/s11255-008-9338-7
Ghana Statistical Service (2021) Ghana 2021 Population and Housing Census; Preliminary Report.
Acheampong, E., Gyasi-Sarpong, C., Yeboah, F., Aboah, K., Laing, E. and Amoah, G. (2018) Predictors of the International Prostate Symptoms Scores for Patients with Lower Urinary Tract Symptoms: A Descriptive Cross-Sectional Study. Urology Annals , 10, 317-323. https://doi.org/10.4103/ua.ua_4_17
Araki, H., Watanabe, H., Mishina, T. and Nakao, M. (1983) High‐Risk Group for Benign Prostatic Hypertrophy. The Prostate , 4, 253-264. https://doi.org/10.1002/pros.2990040305
Glynn, R.J., Campion, E.W., Bouchard, G.R. and Silbert, J.E. (1985) The Development of Benign Prostatic Hyerplasia among Volunteers in the Normative Aging Study. American Journal of Epidemiology , 121, 78-90.
Hunter, D.J.W., Berra-Unamuno, A. and Martin-Gordo, A. (1996) Prevalence of Urinary Symptoms and Other Urological Conditions in Spanish Men 50 Years Old or Older. Journal of Urology , 155, 1965-1970. https://doi.org/10.1016/s0022-5347(01)66063-4
Badia, X., Rodríguez, F., Carballido, J., García Losa, M., Unda, M., Dal-Ré, R., et al . (2001) Influence of Sociodemographic and Health Status Variables on the American Urological Association Symptom Scores in Patients with Lower Urinary Tract Symptoms. Urology , 57, 71-77. https://doi.org/10.1016/s0090-4295(00)00894-3
Asare, G.A., Afriyie, D., Ngala, R.A., Appiah, A.A., Anang, Y., Musah, I., et al . (2015) Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract. Evidence-Based Complementary and Alternative Medicine , 2015, Article 365205. https://doi.org/10.1155/2015/365205
Boyle, P. and Napalkov, P. (1996) Epidemiology of Benign Prostatic Hyperplasia: Current Perspectives. European Urology , 29, 7-11. https://doi.org/10.1159/000473814
Rył, A., Rotter, I., Miazgowski, T., Słojewski, M., Dołęgowska, B., Lubkowska, A., et al . (2015) Metabolic Syndrome and Benign Prostatic Hyperplasia: Association or Coincidence? Diabetology & Metabolic Syndrome , 7, Article No. 94. https://doi.org/10.1186/s13098-015-0089-1
Gacci, M., Sebastianelli, A., Salvi, M., De Nunzio, C., Vignozzi, L., Corona, G., et al . (2017) Benign Prostatic Enlargement Can Be Influenced by Metabolic Profile: Results of a Multicenter Prospective Study. BMC Urology , 17, Article No. 22. https://doi.org/10.1186/s12894-017-0211-9
Pan, J.G., Jiang, C., Luo, R. and Zhou, X. (2013) Association of Metabolic Syndrome and Benign Prostatic Hyperplasia in Chinese Patients of Different Age Decades. Urologia Internationalis , 93, 10-16. https://doi.org/10.1159/000354026
Roehrborn, C.G., Boyle, P., Gould, A.L. and Waldstreicher, J. (1999) Serum Prostate-Specific Antigen as a Predictor of Prostate Volume in Men with Benign Prostatic Hyperplasia. Urology , 53, 581-589. https://doi.org/10.1016/s0090-4295(98)00655-4
Roehrborn, C.G., Malice, M., Cook, T.J. and Girman, C.J. (2001) Clinical Predictors of Spontaneous Acute Urinary Retention in Men with LUTS and Clinical BPH: A Comprehensive Analysis of the Pooled Placebo Groups of Several Large Clinical Trials. Urology , 58, 210-216. https://doi.org/10.1016/s0090-4295(01)01155-4
Tsukamoto, T., Masumori, N., Rahman, M. and Crane, M.M. (2007) Change in International Prostate Symptom Score, Prostrate‐Specific Antigen and Prostate Volume in Patients with Benign Prostatic Hyperplasia Followed Longitudinally. International Journal of Urology , 14, 321-324. https://doi.org/10.1111/j.1442-2042.2007.01596.x
Andersson, S., Rashidkhani, B., Karlberg, L., Wolk, A. and Johansson, J. (2004) Prevalence of Lower Urinary Tract Symptoms in Men Aged 45-79 Years: A Population‐Based Study of 40 000 Swedish Men. BJU International , 94, 327-331. https://doi.org/10.1111/j.1464-410x.2004.04930.x
Roehrborn, C.G., Chinn, H.K.W., Fulgham, P.F., Simpkins, K.L. and Peters, P.C. (1986) The Role of Transabdominal Ultrasound in the Prostatic Hypertrophy. Journal of Urology , 135, 1190-1193. https://doi.org/10.1016/s0022-5347(17)46032-0
Simonsen, O., Møller-Madsen, B., Dørflinger, T., Nørgåard, J.P., Jørgensen, H.S. and Lundhus, E. (1987) The Significance of Age on Symptoms and Urodynamic-and Cystoscopic Findings in Benign Prostatic Hypertrophy. Urological Research , 15, 355-358. https://doi.org/10.1007/bf00265667
Ofoha, C.G., Shu’aibu, S.I., Akpayak, I.C., Dakum, N.K. and Ramyil, V.M. (2015) Relationship between Prostate Volume and IPSS in African Men with Prostate Disease. Jos Journal of Medicine , 9, 16-19.
Barry, M.J., Cockett, A.T.K., Holtgrewe, H.L., McConnell, J.D., Sihelnik, S.A. and Winfield, H.N. (1993) Relationship of Symptoms of Prostatism to Commonly Used Physiological and Anatomical Measures of the Severity of Benign Prostatic Hyperplasia. Journal of Urology , 150, 351-358. https://doi.org/10.1016/s0022-5347(17)35482-4
Bosch, J.L.H.R., Kranse, R., van Mastrigt, R. and Schroder, F.H. (1995) Reasons for the Weak Correlation between Prostate Volume and Urethral Resistance Parameters in Patients with Prostatism. Journal of Urology , 153, 689-693. https://doi.org/10.1016/s0022-5347(01)67687-0
Girman, C.J., Jacobsen, S.J., Guess, H.A., Oesterling, J.E., Chute, C.G., Panser, L.A., et al . (1995) Natural History of Prostatism: Relationship among Symptoms, Prostate Volume and Peak Urinary Flow Rate. Journal of Urology , 153, 1510-1515. https://doi.org/10.1016/s0022-5347(01)67448-2
Awaisu, M., Ahmed, M., Lawal, A.T., Sudi, A., Tolani, M.A., Oyelowo, N., et al . (2021) Correlation of Prostate Volume with Severity of Lower Urinary Tract Symptoms as Measured by International Prostate Symptoms Score and Maximum Urine Flow Rate among Patients with Benign Prostatic Hyperplasia. African Journal of Urology , 27, Article No. 16. https://doi.org/10.1186/s12301-021-00122-4