Biopolymer Sponge for High Grade Renal Trauma: An Experimental Study in Rabbits
- 1 Department of Surgery, Federal University of Paraiba, University Hospital Lauro Wanderley, Joao Pessoa, Brazil
- 2 Department of Surgery, Federal University of Pernambuco, Clinics Hospital, Recife, Brazil
- 3 Department of Surgery, Federal University of Pernambuco, Clinics Hospital, Recife, Brazil
- 4 Department of Surgery, Federal University of Paraiba, University Hospital Lauro Wanderley, Joao Pessoa, Brazil
- 5 Department of Surgery, Federal University of Pernambuco, Clinics Hospital, Recife, Brazil
- 6 Department of Surgery, Federal University of Paraiba, University Hospital Lauro Wanderley, Joao Pessoa, Brazil
Abstract
Introduction: Acute blunt or open renal trauma sometimes requires conservative me a sure which involves the use of specific materials in order to adequately restore renal parenchima. The purpose of this study is to analyze the effects of the sugar cane biopolymer sponge in an experimental model of renal trauma in rabbits. Methods : Experimental prospective study was paired with twelve New Zealand rabbits. After induction of renal trauma bilateral high-grade (grade 4-collecting system, according to AAST), the sugar cane biopolymer sponge was used for homeostasis and reconstruction of the right renal parenchyma (experimental group). The same procedure was performed in the left kidney, but using the Surgifoam ? sponge (Control Group). The animals were sacrificed after four weeks. Histological analysis was performed and the results were compared after statistically being evaluated. Results: Comparing the experimental group with the control, there was more inflammatory reaction and premature adhesions in the first one. Concerning the influence on efficacy and biocompatibility of the biopolymer , no serious complications like massive bleeding, haematoma, fistula or urinary stone formation were found in both groups. Conclusion: The sugar cane biopolymer sponge demonstrated good efficacy in relation to hemostatic control and reconstruction of the renal parenchyma without major complications. Future studies may direct its routine use in urologic practice.
- M. Paterson-Beedle, J. F. Kennedy, et al., “A Cellulosic Exopolysaccharide Produced from Sugarcane Molasses by a Zoogloea sp.,” Carbohydrate Polymers, Vol. 42, No. 4, 2000, pp. 375-383.
- L. W. Jonathan, B. N. Avery, et al., “Renal and Extrarenal Predictors of Nephrectomy from the National Trauma Data Bank,” Journal of Urology, Vol. 175, No. 3, 2006, pp. 970-975.
- J. Peters, J. Green, et al., “Kidney Salvage Using the Fibrinogen-and Thrombin-Coated Sponge TachoSil® during Nephron-Sparing Surgery for the Resection of Large Renal Tumors,” Annals of The Royal College of Surgeons of England, Vol. 90, No. 5, 2008, pp. 1-3.
- X. M. D. Roa Saveedra, J. A. Cajigas Plata, et al., “Sellantes de Fibrin en Urología,” Urológica Colombiana, Vol. 17, No. 1, 2008, pp. 55-62.
- K. Hwang, S. G. Kim and D. J. Kim, “Hypoglossal-Facial Nerve Anastomosis in the Rabbits Using Laser Welding,” Annals of Plastic Surgery, Vol. 61, No. 4, 2008, pp. 452456.
- N. Y. Oct & Gul, A. Topal, I. T. Cangul and K. Yanik, “The Effects of Topical Tripeptide Copper Complex and Helium-Neon Laser on Wound Healing in Rabbits,” Expert Review of Dermatology, Vol. 19, No. 1, 2008 pp. 7-14.
- K. Bjorses and J. Holst, “Topical Haemostatics in Renal Trauma—An Evaluation of Four Different Substances in an Experimental Setting,” Journal of Trauma, Vol. 66, No. 3, 2009, pp. 602-1
- R. Dimitrov, D. Kostov, et al., “Anatomotopographical and Morphological Analysis of Normal Kidneys of Rabbit (Oryctolagus cuniculus),” Trakia Journal of Sciences, Vol. 10, No. 2, 2012, pp. 79-84.
- F. Massole and V. Anesthesiology, “Pharmacology and technology,” 4th Edition, Guanabara Koogan, Rio de Janeiro, 2003.
- A. J. Wein, L. R. Kavoussi, et al., “Campbell’s Urology,” 7 Edition, WB Saunders, Philadephia, 1998.
- E. J. Hick, A. F. Morey, et al., “Gelatin Matrix Treatment of Complex Renal Injuries in a Porcine Model,” Urology Journal, Vol. 173, No. 5, 2005, pp. 1801-1804.
- C. M. M. B. Castro, J. L. A. Aguiar, et al., “Cytotoxicity Biopolymer Sugar Cane,” Anais da Faculdadede Medicina da Universidade Federal de Pernambuco, Vol. 49, No. 2, 2004, pp. 119-123.
- F. Vilar, J. L. Aguiar, et al., “Peyonie Disease: Study of a New Material with a View to Clinical Application,” International Brazilian Journal of Urology, Vol. 32, No. 2, 2006, p. 167.