Late recurrence of renal cell carcinoma (RCC), arbitrarily defined, as >10 years post-nephrectomy, is rare. Here we review 43 reports comprising 467 cases. Metastasis occurred between few months and 45 years. We report a new case with a 10-year interval to metastasis.
Chawla, A., Mishra, D., Bansal, R. and Chundra, M. (2013) Rare Sites of Delayed Metastasis in Renal Cell Carcinoma. BMJ Case Reports, 2013, bcr2013009971. http://dx.doi.org/10.1136/bcr-2013-009971
Sameh, W.M., Hashad, M.M., Eid, A.A., Abou Yousif, T.A. and Mohammed, A. (2012) Recurrence Pattern in Patients with Locally Advanced Renal Cell Carcinoma: The Implications of Clinicopathological Variables. Arab Journal of Urology, 10, 131-137. http://dx.doi.org/10.1016/j.aju.2011.12.007
Fokt, R.-M., Templeton, A., Gillessen, S., Ohlschlegel, C., et al. (2009) Prostatic Metastasis of Renal Cell Carcinoma Successfully Treated with Sunitinib. Urologia Internationalis, 83, 122-124. http://dx.doi.org/10.1159/000224882
Choi, W.H., Koh, Y.-C., Song, S.W., Roh, H.G. and Lim, S.-D. (2013) Extremely Delayed Brain Metastasis from Renal Cell Carcinoma. Brain Tumor Research and Treatment, 1, 99-102. http://dx.doi.org/10.14791/btrt.2013.1.2.99
Pickhardt, P.J. and Pickard, R.H. (2003) Sonography of Delayed Thyroid Metastasis from Renal Cell Carcinoma with Jugular Vein Extension. AJR, 181, 272-274. http://dx.doi.org/10.2214/ajr.181.1.1810272
Kolokythas, A., Weiskopf, S., Singh, M. and Cabay, R.J. (2015) Renal Cell Carcinoma: Delayed Metachronous Metastases to Parotid and Cerebellum. Journal of Oral and Maxillofascial Surgery, 73, 1296-1303. http://dx.doi.org/10.1016/j.joms.2015.01.017
Montano, N., Puca, A., Pierconti, F. and Larocca, L.M. (2007) Extremely Delayed Falx Metastasis from Renal Cell Carcinoma. Neurology, 68, 1541. http://dx.doi.org/10.1212/01.wnl.0000261253.45209.97
Davies, J.R.L., Smith, G., Cornaby, A.J., Thomas, T. and Lamparelli, M.J. (2015) Delayed Recurrence of Renal Cell Carcinoma Presenting as a Haemorrhoid. Journal of Surgical Case Reports, 3, rjv022.
Roser, F., Rosahl, S.K. and Samii, M. (2002) Single Cerebral Metastasis 3 and 19 Years after Primary Renal Cell Carcinoma: Case Report and Review of the Literature. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 257-258. http://dx.doi.org/10.1136/jnnp.72.2.257
Hosn-Centenero, S.A., Coll-Anglada, M., Pradillos-Garcés, A. and Salinas-Duffo, D. (2014) STUDYA Rare Case of Renal Cell Carcinoma Metastasis in the Parotid Gland Eleven Years after the Initial Diagnosis. Acta Otorrinolaringológica Espanola, 65, 375-377. http://dx.doi.org/10.1016/j.otorri.2013.03.005
Citgez, B., Uludag, M., Gurbulak, E.K., Ozguven, B.Y., et al. (2011) Thyroid Metastasis of Renal Cell Carcinoma. World Journal of Endocrine Surgery, 3, 93-95. http://dx.doi.org/10.5005/jp-journals-10002-1066
Shi, J.-L., Zhou, J.-Q. and Li, J.-P. (2015) Renal Clear Cell Carcinoma with Thyroid and Parotid Metastases: A Case Report. Oncology Letters, 10, 2617-2619. http://dx.doi.org/10.3892/ol.2015.3549
Gogüs, O.A., Kilic, O., Tulunay, O., Tulunay, O. and Bedük, Y. (2004) Solitary Metastasis of Renal Cell Carcinoma to the Parotid Gland 10 Years after Radical Nephrectomy. International Journal of Urology, 11, 894-896. http://dx.doi.org/10.1111/j.1442-2042.2004.00902.x
Moudouni, S.M., Tligui, M., Doublet, J.D., Haab, F., Gattegno, B. and Thibault, P. (2006) Late Metastasis of Renal Cell Carcinoma to the Submaxillary Gland 10 Years after Radical Nephrectomy. International Journal of Urology, 13, 431-432. http://dx.doi.org/10.1111/j.1442-2042.2006.01318.x
Sadatomo, T., Yuki, K., Migita, K., Taniguchi, E., Kodama, Y. and Kurisu, K. (2005) Solitary Brain Metastasis from Renal Cell Carcinoma 15 Years after Nephrectomy. Neurologia Medico-Chirurgica (Tokyo), 45, 423-427. http://dx.doi.org/10.2176/nmc.45.423
Gil-Julio, H., Vázquez-Alonso, F., Fernández-Sánchez, A.J., Puche-Sanz, I., Flores-Martín, J.F. and Cózar, J.M. (2012) Metastasis of Renal Cell Carcinoma to the Buccal Mucosa 19 Years after Radical Nephrectomy. Case Reports in Oncological Medicine, 2012, Article ID: 823042. http://dx.doi.org/10.1155/2012/823042
Kadrian, D. and Tan, L. (2004) Single Choroid Plexus Metastasis 16 Years after Nephrectomy for Renal Cell Carcinoma: Case Report and Review of the Literature. Journal of Clinical Neuroscience, 11, 88-91. http://dx.doi.org/10.1016/j.jocn.2002.09.002
Macedo-Alves, D., Koca, P., Soares, V., Gouveia, P., Honavar, M. and Taveira-Gomes, A. (2015) Thyroid Metastasis from Renal Cell Carcinoma—A Case Report after 9 Years. International Journal of Surgery Case Reports, 16, 59-63. http://dx.doi.org/10.1016/j.ijscr.2015.09.004
Kihara, M., Yokomise, H. and Yamauchi, A. (2004) Metastasis of Renal Cell Carcinoma to the Thyroid Gland 19 Years after Nephrectomy. Auris Nasus Larynx, 31, 95-100. http://dx.doi.org/10.1016/j.anl.2003.09.002
De Jesus, C.M.N., Casafus, F.A.S. and Agostinho, A.D. (2008) Surgical Treatment of Renal Cell Carcinoma Recurrence at the Renal Fossa Following Radical Nephrectomy. Sao Paulo Medical Journal, 126, 194-196. http://dx.doi.org/10.1590/S1516-31802008000300011
Adamy, A., Chong, K.T., Chade, D., Costaras, J., Russo, G., Kaag, M.G., Bernstein, M., Motzer, R.J. and Russo, P. (2011) Clinical Characteristics and Outcomes of Patients with Recurrence 5 Years after Nephrectomy for Localized Renal Cell Carcinoma. The Journal of Urology, 185, 433-438. http://dx.doi.org/10.1016/j.juro.2010.09.100
Park, Y.H., Baik, K.D., Lee, Y.J., Ku, J.H., et al. (2012) Late Recurrence of Renal Cell Carcinoma > 5 Years after Surgery: Clinicopathological Characteristics and Prognosis. BJU International, 110, E553-E558. http://dx.doi.org/10.1111/j.1464-410X.2012.11246.x
Tapper, H., Klein, H., Rubenstein, W., Intriere, L., Choi, Y. and Kazam, E. (1997) Recurrent Renal Cell Carcinoma after 45 Years. Clinical Imaging, 21, 273-275. http://dx.doi.org/10.1016/S0899-7071(96)00042-3
Miah, M.S., White, S.J., Oommen, G., Birney, E. and Majumdar, S. (2010) Late Simultaneous Metastasis of Renal Cell Carcinoma to the Submandibular and Thyroid Glands Seven Years after Radical Nephrectomy. International Journal of Otolaryngology, 2010, Article ID: 698014. http://dx.doi.org/10.1155/2010/698014
Saidi, R.F. and Remine, S.G. (2007) Isolated Gastric Metastasis from Renal Cell Carcinoma 10 Years after Radical Nephrectomy. Journal of Gastroenterology and Hepatology, 22, 140-144. http://dx.doi.org/10.1111/j.1440-1746.2006.04335.x
Sugasawa, H., Ichikura, T., Ono, S., Tsujimoto, H., et al. (2010) Isolated Gastric Metastasis from Renal Cell Carcinoma 19 Years after Radical Nephrectomy. International Journal of Clinical Oncology, 15, 196-200. http://dx.doi.org/10.1007/s10147-010-0025-1
Wilkinson, L., Tervit, G. and Bloxham, C. (2008) Metastatic Renal Cell Carcinoma to the Thyroid Gland Presenting 17 Years after Nephrectomy. Diagnostic Histopathology, 14, 408-410. http://dx.doi.org/10.1016/j.mpdhp.2008.06.013
Chin, C.J., Franklin, J.H., Moussa, M. and Chin, J.L. (2011) Metastasis from Renal Cell Carcinoma to the Thyroid 12 Years after Nephrectomy. Canadian Medical Association Journal, 183, 1398-1399. http://dx.doi.org/10.1503/cmaj.092152
Fuente Bartolomé, M., Osorio Silla, I., Gutiérrez Samaniego, M., Martinez Pueyo, J.I. and de La Cruz Vigo, F. (2014) Metastasis en tiroides de carcinoma renal de células claras. Endocrinología y Nutrición, 61, 296-297. http://dx.doi.org/10.1016/j.endonu.2013.12.002
Takashi, M., Hibi, H., Ohmura, M., Sate, K., Sakata, T. and Ando, M. (1997) Renal Fossa Recurrence of a Renal Cell Carcinoma 13 Years after Nephrectomy: A Case Report. International Journal of Urology, 4, 508-511. http://dx.doi.org/10.1111/j.1442-2042.1997.tb00294.x
Brookman-May, S., May, M., Shariat, S.F., Xylinas, E., et al. (2013) Features Associated with Recurrence beyond 5 Years after Nephrectomy and Nephron-Sparing Surgery for Renal Cell Carcinoma: Development and Internal Validation of a Risk Model (PRELANE Score) to Predict Late Recurrence Based on a Large Multicenter Database (CORONA/SATURN Project). European Urology, 64, 472-477. http://dx.doi.org/10.1016/j.eururo.2012.06.030
Miyao, N., Naito, S., Ozono, S., Shinohara, N., et al. (2011) Late Recurrence of Renal Cell Carcinoma: Retrospective and Collaborative Study of the Japanese Society of Renal Cancer. Urology, 77, 379-384. http://dx.doi.org/10.1016/j.urology.2010.07.462
Heckl, S., Braun, K., Debus, J. and Kunze, S. (2003) Cerebral Metastasis after Primary Renal Cell Carcinoma. Journal of Neurology, Neurosurgery & Psychiatry, 74, 141. http://dx.doi.org/10.1136/jnnp.74.1.141
Bradham, R.R., Wannamaker, C.C. and Pratt-Thomas, H.R. (1973) Renal Cell Carcinoma Metastases 25 Years after Nephrectomy. JAMA, 223, 921-922. http://dx.doi.org/10.1001/jama.1973.03220080051019
Lee, J.G., Kim, J.S., Kim, H.J., Kim, S.T., et al. (2002) Simultaneous Duodenal and Colon Masses as Late Presentation of Metastatic Renal Cell Carcinoma. The Korean Journal of Internal Medicine, 17, 143-146. http://dx.doi.org/10.3904/kjim.2002.17.2.143
Sotiropoulos, G.C., Lang, H., Liu, C., Brokalaki, E.I., et al. (2005) Surgical Treatment of Pancreatic Metastases of Renal Cell Carcinoma. Journal of the Pancreas, 6, 339-343.
Namikawa, T., Iwabu, J., Kitagawa, H., Okabayashi, T., et al. (2012) Solitary Gastric Metastasis from a Renal Cell Carcinoma, Presenting 23 Years after Radical Nephrectomy. Endoscopy, 44, E177-E178. http://dx.doi.org/10.1055/s-0031-1291751
Dellon, E.S. and Gangarosa, L.M. (2006) Hematochezia Due to a Renal Cell Carcinoma Metastasis to the Rectum: A Case Report and Review of the Literature. Revista de Gastroenterología de México, 71, 316-318.
Pezzoli, A., Matarese, V., Boccia, S., Simone, L. and Gullini, S. (2007) Gastrointestinal Bleeding from Gastric Metastasis of Renal Cell Carcinoma, Treated by Endoscopic Polypectomy. Endoscopy, 39, E52. http://dx.doi.org/10.1055/s-2006-945127
Riviello, C., Tanini, I., Cipriani, G., Pantaleo, P., et al. (2006) Unusual Gastric and Pancreatic Metastatic Renal Cell Carcinoma Presentation 10 Years after Surgery and Immunotherapy: A Case Report and a Review of Literature. World Journal of Gastroenterology, 12, 5234-5236.
Costa, T.N., Takeda, F.R., Ribeiro Jr., U. and Cecconello, I. (2014) Palliative Laparoscopic Resection of Renal Cell Carcinoma Metastatic to the Stomach: Report of a Case. World Journal of Surgical Oncology, 12, 394. http://dx.doi.org/10.1186/1477-7819-12-394
Chang, W.-T., Chai, C.-Y. and Lee, K.-T. (2004) Unusual Upper Gastro-Intestinal Bleeding Due to Late Metastasis from Renal Cell Carcinoma: A Case Report. The Kaohsiung Journal of Medical Sciences, 20, 137-141. http://dx.doi.org/10.1016/S1607-551X(09)70098-1