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Therapeutic Outcome of Botulinum Toxin Type A for Patients with Low Bladder Compliance Secondary to Spinal Cord Injury
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Departments of Urology, Qingyan City People’s Hospital, Jinan University, Guangdong, China
Departments of Urology, Qingyan City People’s Hospital, Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 1 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 2 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 3 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 4 Departments of Urology, Qingyan City People’s Hospital, Jinan University, Guangdong, China
- 5 Departments of Urology, Qingyan City People’s Hospital, Jinan University, Guangdong, China
- 6 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 7 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 8 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
- 9 Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University, Guangdong, China
Open Journal of Urology·Volume 07 (2017)·Pages 207–211·Published 2 November 2017·DOI10.4236/oju.2017.711024
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Abstract
Objective: To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in treating patients with low bladder compliance (BC) secondary to spinal cord injury (SCI). Methods: From 2011 to 2016, we retrospected patients who received BTX-A injections for LBC secondary to SCI. The primary outcomes were urodynamic parameters including maximum detrusor pressure (Pdetmax), bladder compliance (BC). Related adverse events were recorded. Results: 72 SCI patients were selected (62 males, 10 females, age range 18 - 52 years; mean age 28.5 years). 12 weeks after BTX-A injection, Pdetmax decreased from 51.02 cmH 2 O to 28.31 cmH 2 O. BC increased from 3.64 ml/cmH 2 O to 10.08 ml/cmH 2 O. 12 patients had mild transient haematuria for 1 - 2 days. Conclusion: Intradetrusor BTX-A injection was effective and safe for patients with low BC secondary to SCI.
KeywordsBotulinum Toxin Type ALow Bladder ComplianceSpinal Cord Injury
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