Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 1
- 1 Nordica Fertility Center, Lagos, Nigeria
- 2 Health, Environment and Development Foundation, Lagos, Nigeria
- 3 Nordica Fertility Center, Lagos, Nigeria
- 4 Nordica Fertility Center, Lagos, Nigeria
- 5 Nordica Fertility Center, Lagos, Nigeria
- 6 Nordica Fertility Center, Lagos, Nigeria
- 7 Nordica Fertility Center, Lagos, Nigeria
- 8 Nordica Fertility Center, Lagos, Nigeria
- 9 Nordica Fertility Center, Lagos, Nigeria
Abstract
Introduction: In humans, the ideal ejaculation frequency depends on age, exercise and sexual potential. Natural ejaculation frequency balances the testosterone levels in the body. Materials and Methods: Semi-structured questionnaire was used to collect information from subjects. Semen samples were collected from sperm donors and sub-fertile men who presented for infertility challenges. Processing and analysis of semen samples were done according to World Health Organization guidelines. Sperm DNA fragmentation was evaluated using the Halosperm ® kit. Results: A total of 114 subjects, including 19 sperm donors and 95 sub-fertile males were studied. There was a significant difference (t = − 5.96, P-value = 0.00001) in the mean [±sd] age of sperm donors (30.8 [8.1]) and that of sub-fertile men (42.3 [76]). There was a significant difference (t= − 4.10, P-value = 0.0005) in the mean monthly ejaculation during sexual intercourse (MESI) among sperm donors with DNA fragmentation index < 25% (3.0 [1.0]) compared to those with DNA fragmentation index ≥ 25% (9.3 [5.5]). There was also a significant difference (t= − 2.20, P-value = 0.02) in MESI among sub-fertile men aged ≥40 years (8.9 [4.6]) than among those aged <40 years (10.8 [3.8]). Entrepreneurs (59.3%) and non-smokers (84.6%) reported higher frequency (16 - 20) of MESI than others. There was a significant but negative correlation between frequency of MESI and DNA fragmentation index category (coef. = − 0.67, SE = 0.28, t = − 2.40, P-value = 0.02, 95% CI: − 1.24, − 0.10). Conclusion: In men < 40 years, fewer MESI did not worsen the DFI. A higher number of professionals such as doctors, lawyers and engineers, reported lower monthly frequency of sexual ejaculations compared to entrepreneurs. Entrepreneurs and non-smokers had the highest frequencies of MESI.
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