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<i>Baccaurea ramiflora</i>: Isolation of Aldehydes and in Vitro Biological Investigations
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
- 1 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
- 2 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
- 3 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
Pharmacology & Pharmacy·Volume 11 (2020)·Pages 147–157·Published 13 July 2020·DOI10.4236/pp.2020.117014
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Abstract
The stem bark of Baccaurea ramiflora was studied. Four aldehydes named as 3 methoxy 4 hydroxy - cinnamaldehyde (coniferyl aldehyde); 3, 4, 5 trimethoxy cinnamaldehyde; 3, 4, 5 trimethoxy benzaldehyde and 3,4 dimethoxy benzaldehyde) (veratraldehyde) have been isolated and then identified by NMR spectroscopy. All of them are first time reported for this plant. Here in vitro biological investigations include antioxidant and cytotoxicity study. Among all fractions, the chloroform soluble fraction exhibited strong free radical scavenging activity having IC 50 value of 12.87 μg/ml compared to BHT (IC 50 value 5.64 μg/ml). On the contrary, aqueous soluble fraction exhibited most toxicity towards brine shrimp compared with vincristine sulphate having LC 50 value of 1.44 and 0.9258 μg/ml respectively.
Keywords<i>Baccaurea ramiflora</i>AldehydeNMR SpectroscopyAntioxidantCytotoxicity
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