Free Radical Scavenging, Enzyme Inhibitory and Anti-<i>Staphylococcus aureus</i> Properties of the Fruiting Bodies of <i>Ganoderma lucidum</i>, Lingzhi Mushroom — Oak Academic Publishing
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Free Radical Scavenging, Enzyme Inhibitory and Anti-<i>Staphylococcus aureus</i> Properties of the Fruiting Bodies of <i>Ganoderma lucidum</i>, Lingzhi Mushroom
Institute of Biological Science, University of Rajshahi, Rajshahi, Bangladesh
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Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh
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Department of Pharmacy, Pabna University of Science and Technology, Pabna, Bangladesh
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RHSTEP, Dhaka Medical College Hospital, Dhaka, Bangladesh
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Department of Biochemistry & Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
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School of Science, Independent University of Bangladesh, Dhaka, Bangladesh
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Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan
1 Institute of Biological Science, University of Rajshahi, Rajshahi, Bangladesh
2 Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh
3 Department of Pharmacy, Pabna University of Science and Technology, Pabna, Bangladesh
4 RHSTEP, Dhaka Medical College Hospital, Dhaka, Bangladesh
5 Department of Biochemistry & Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
6 School of Science, Independent University of Bangladesh, Dhaka, Bangladesh
7 Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan
The current study evaluated the antioxidant, α -amylase inhibitory and anti- Staphylococcus aureus activities of the fruiting bodies of Ganoderma lucidum . Methanolic extract of G. lucidum (MEGL) was investigated for its in vitro antioxidant activity using 1,1-diphenyl 2-picrylhydrazyl (DPPH) assay and EC 50 value was determined. α -Amylase inhibitory and anti- S. aureus activities were carried out by conventional methods. The mushroom extract showed maximum free radical scavenging activity at a dose of 500 μg/mL with EC 50 value of 22.1399 μg/mL. EC 50 value for the inhibition of α -amylase activity was found 22.6011 μg/mL. G. lucidum extracts exhibited a concentration-dependent Anti- S. aureus activity. The vast differences of this inhibition between lower and higher doses were assessed significantly (p < 0.05). This study shows that the fruiting body of G. lucidum has moderate antioxidant, α -amylase inhibitory, and anti- S. aureus activities. Thus this mushroom may be the alternative plant source for the antioxidant, anti-diabetic and antibacterial agents and further in vivo studies and isolation of bioactive compounds are required.
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